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Pathology x Preclinical Medicine x Physiology x clear all

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Manuel Noben, Sebastiaan De Schepper, Gert Van Assche, Marc Ferrante and Séverine Vermeire.

in Journal of Crohn's and Colitis

January 2018; p ublished online September 2017 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 6507 words.

Abstract

Background

Endoplasmic reticulum [ER] stress was shown to be pivotal in the pathogenesis of inflammatory...

CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease

Pedro Salvador, Dulce Carolina Macías-Ceja, Laura Gisbert-Ferrándiz, Carlos Hernández, David Bernardo, Rafael Alós, Francisco Navarro-Vicente, Juan Vicente Esplugues, Dolores Ortiz-Masiá, Maria Dolores Barrachina and Sara Calatayud.

in Journal of Crohn's and Colitis

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 5609 words.

Abstract

Background and Aims

Fibrosis is a common complication of Crohn’s disease [CD], and is related to...

Claypon, Janet Elizabeth Lane- [married name Janet Elizabeth Forber, Lady Forber] (1877–1967), physiologist and epidemiologist

Warren Winkelstein,.

in Oxford Dictionary of National Biography

September 2004; p ublished online September 2004 .

Reference Entry. Subjects: Physiology; Epidemiology; Pathology. 1310 words.

Claypon, Janet Elizabeth Lane- [married name Janet Elizabeth Forber, Lady Forber] (1877–1967), physiologist and epidemiologist, was born on 3 February 1877 at 118 High Street, Boston,...

Development of Reliable, Valid and Responsive Scoring Systems for Endoscopy and Histology in Animal Models for Inflammatory Bowel Disease

Pim J Koelink, Manon E Wildenberg, Larry W Stitt, Brian G Feagan, Martin Koldijk, Angélique B van ‘t Wout, Raja Atreya, Michael Vieth, Johannan F Brandse, Suzanne Duijst, Anje A te Velde, Geert R A M D’Haens, Barrett G Levesque and Gijs R van den Brink.

in Journal of Crohn's and Colitis

June 2018; p ublished online March 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 5667 words.

Abstract

Background and Aims

Although several endoscopic and histopathologic indices are available for evaluating...

Dietary Supplementation With a Bacillus Superoxide Dismutase Protects Against γ-Radiation-induced Oxidative Stress and Ameliorates Dextran Sulphate Sodium-induced Ulcerative Colitis in Mice

Ji-Eun Kang, Hyun-Do Kim, Soo-Young Park, Jae-Gu Pan, Jeong Hyun Kim and Do-Young Yum.

in Journal of Crohn's and Colitis

June 2018; p ublished online March 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 6849 words.

Abstract

Background and Aims

Commercial superoxide dismutase [SOD] is derived from melon extract and has a...

Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn’s Disease: Report of the TOSCA Study

Geert D’Haens, Séverine Vermeire, Harald Vogelsang, Matthieu Allez, Pierre Desreumaux, Andre Van Gossum, William J Sandborn, Daniel C Baumgart, Richard M Ransohoff, Gail M Comer, Alaa Ahmad, Fabio Cataldi, John Cheng, Robert Clare, Kenneth J Gorelick, Annamarie Kaminski, Vivek Pradhan, Sunday Rivers, Matthew O Sikpi, Yanhua Zhang, Mina Hassan-Zahraee, Walter Reinisch and Olaf Stuve.

in Journal of Crohn's and Colitis

January 2018; p ublished online September 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Gastroenterology; Pathology; Physiology; Research Methods in Life Sciences. 5592 words.

Abstract

Background and Aims

Progressive multifocal leukoencephalopathy [PML], a brain infection associated with...

The Effect of Vitamin D on Intestinal Inflammation and Faecal Microbiota in Patients with Ulcerative Colitis

Mayur Garg, Philip Hendy, John Nik Ding, Sophie Shaw, Georgina Hold and Ailsa Hart.

in Journal of Crohn's and Colitis

July 2018; p ublished online May 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences; Medical Microbiology and Virology. 5711 words.

Abstract

Background and Aims

Vitamin D may be immunomodulatory and alter faecal microbiota, but results from...

An Examination of Appetite and Disordered Eating in Active Crohn’s Disease

Richard Anthony Wardle, Gita Thapaliya, Adam Nowak, Shellie Radford, Michelle Dalton, Graham Finlayson and Gordon W Moran.

in Journal of Crohn's and Colitis

June 2018; p ublished online April 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences; Economics of Health; Health, Illness, and Medicine; Gastroenterology. 5730 words.

Abstract

Background

Crohn’s disease [CD] patients suffer from nutritional deficiencies when in active disease. We...

Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition

Jessica R de Bruyn, Gijs R van den Brink, Jessica Steenkamer, Christianne J Buskens, Willem A Bemelman, Sander Meisner, Vanesa Muncan, Anje A te Velde, Geert R D’Haens and Manon E Wildenberg.

in Journal of Crohn's and Colitis

June 2018; p ublished online April 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 6399 words.

Abstract

Background and Aims

Crohn’s disease is a chronic inflammatory disorder of the intestine and often leads to...

FitzGerald, Mabel Purefoy (1872–1973), physiologist and clinical pathologist

R. W. Torrance.

in Oxford Dictionary of National Biography

September 2004; p ublished online September 2004 .

Reference Entry. Subjects: Social and Cultural History; Physiology; Pathology. 728 words.

FitzGerald, Mabel Purefoy (1872–1973), physiologist and clinical pathologist, was born on 3 August 1872 at North Hall, Preston Candover, Hampshire, the last of the seven children of Richard...

Gastric and Oesophageal Surgery

Edited by M. Asif Chaudry, Sri G. Thrumurthy and Muntzer Mughal.

April 2014; p ublished online April 2014 .

Book. Subjects: Surgery; Upper Gastrointestinal Surgery; Preclinical Medicine; Physiology; Surgical Skills; Histopathology; Peri-operative Care; Surgical Oncology; Bariatric Surgery; Critical Care. 368 pages.

Gastric and Oesophageal Surgery serves as a detailed, evidence-based guide to benign and malignant oesophageal and gastric surgery, covering in a practical and accessible manner the myriad...

Go to »  abstract

Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn’s Disease

Marijn C Visschedijk, Lieke M Spekhorst, Shih-Chin Cheng, Ellen S van Loo, B H Dianne Jansen, Tjasso Blokzijl, Hyunsuk Kil, Dirk J de Jong, Marieke Pierik, Jeroen P W J Maljaars, C Janneke van der Woude, Adriaan A van Bodegraven, Bas Oldenburg, Mark Löwenberg, Vincent B Nieuwenhuijs, Floris Imhann, Suzanne van Sommeren, Rudi Alberts, Ramnik J Xavier, Gerard Dijkstra, Klaas Nico Faber, C Marcelo Aldaz, Rinse K Weersma and Eleonora A M Festen.

in Journal of Crohn's and Colitis

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences; Clinical Genetics; Epidemiology. 4512 words.

Abstract

Background and Aims

Crohn’s disease [CD] is a chronic inflammatory disease with unpredictable behaviour....

Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis

Daniel G W Johnston, Michelle A Williams, Christoph A Thaiss, Raul Cabrera-Rubio, Mathilde Raverdeau, Craig McEntee, Paul D Cotter, Eran Elinav, Luke A J O’Neill and Sinéad C Corr.

in Journal of Crohn's and Colitis

June 2018; p ublished online March 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 7808 words.

Abstract

Background and Aims

microRNAs regulate gene expression and influence the pathogenesis of human diseases....

Martin, Sir Charles James (1866–1955), physiologist and pathologist

Harriette Chick.

in Oxford Dictionary of National Biography

September 2004; p ublished online September 2004 .

Reference Entry. Subjects: Physiology; Pathology. 1394 words.

Martin, Sir Charles James (1866–1955), physiologist and pathologist, was born at Wilmot House, Dalston, London, on 9 January 1866, the twelfth child and youngest son of Josiah Martin,...

MicroRNA-590-5p Inhibits Intestinal Inflammation by Targeting YAP

Minhao Yu, Yang Luo, Zhijie Cong, Yifei Mu, Yier Qiu and Ming Zhong.

in Journal of Crohn's and Colitis

July 2018; p ublished online April 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences; Gastro-intestinal and Colorectal Surgery. 6035 words.

Abstract

Background and Aims

Hippo signalling is an evolutionarily conserved pathway that controls organ size by...

Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

Mingzhen Zhang, Changlong Xu, Dandan Liu, Moon Kwon Han, Lixin Wang and Didier Merlin.

in Journal of Crohn's and Colitis

January 2018; p ublished online August 2017 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 7784 words.

Abstract

Background and Aims

Oral drug delivery is the most attractive pathway for ulcerative colitis [UC] therapy,...

Pathogenicity of In Vivo Generated Intestinal Th17 Lymphocytes is IFNγ Dependent

Giulia Nizzoli, Claudia Burrello, Fulvia Milena Cribiù, Giulia Lovati, Giulia Ercoli, Fiorenzo Botti, Elena Trombetta, Laura Porretti, Katia Todoerti, Antonino Neri, Maria Rita Giuffrè, Jens Geginat, Maurizio Vecchi, Maria Rescigno, Moira Paroni, Flavio Caprioli and Federica Facciotti.

in Journal of Crohn's and Colitis

July 2018; p ublished online April 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 7553 words.

Abstract

Background and Aims

T helper 17 [Th17] cells are crucially involved in the immunopathogenesis of...

Pelvic Floor Disorders for the Colorectal Surgeon

Edited by Ian Lindsey, Karen Nugent and Tony Dixon.

October 2010; p ublished online May 2013 .

Book. Subjects: Colorectal Surgery; Communication Skills; Clinical Radiology; Physiology; Pathology; Pain Medicine; Obstetrics; Neurology; Surgical Skills. 288 pages.

This resource provides a modern, thought-provoking approach to pelvic floor disorders, and is written by emerging young leaders in the field. These conditions are of high importance and...

Go to »  abstract

Role of Vitamin D in the Natural History of Inflammatory Bowel Disease

Ole Haagen Nielsen, Lars Rejnmark and Alan C Moss.

in Journal of Crohn's and Colitis

May 2018; p ublished online February 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 8650 words.

Abstract

Inflammatory bowel disease [IBD], including ulcerative colitis and Crohn’s disease, is a chronic and unpredictable condition characterised by...

Sanderson, Sir John Scott Burdon, baronet (1828–1905), pathologist and physiologist

Steve Sturdy.

in Oxford Dictionary of National Biography

September 2004; p ublished online September 2004 .

Reference Entry. Subjects: Physiology; Pathology. 3264 words.

Sanderson, Sir John Scott Burdon, baronet (1828–1905), pathologist and physiologist, was born at Jesmond, near Newcastle upon Tyne, on 21 December 1828, the second son and fourth child of...