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Public Health and Epidemiology x Clinical Pharmacology and Therapeutics x clear all

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activated charcoal

Overview page. Subjects: Clinical Pharmacology and Therapeutics — Public Health and Epidemiology.

A preparation of charcoal that can adsorb toxicants, e.g., narcotics, chlorine gas. It is used in water filtration devices to remove organic chemical contaminants from drinking water and as...

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Basics of Phase I Design

Donna M. Graham, Aaron R. Hansen, Elizabeth A. Eisenhauer and Lillian L. Siu.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 12950 words.

This chapter will focus on the fundamental principles of phase I trials of agents that are entering the clinic for the first time. Initial preclinical testing of these drugs utilize in vivonull...

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Controversies in the Management of Salivary Gland Disease

Edited by Mark McGurk and James Graham Combes.

November 2012; p ublished online May 2013 .

Book. Subjects: Surgery; Histopathology; Epidemiology; Oral and Maxillofacial Surgery; Anaesthetics; Surgical Skills; Paediatrics; Medical Oncology; Surgical Oncology; Clinical Radiology; Clinical Pharmacology and Therapeutics. 376 pages.

Addressing controversial and topical issues in the field of salivary gland disease and surgical management of salivary gland disease, this new edition integrates the newest clinical...

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Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease

Leonardo Guizzetti, Guangyong Zou, Reena Khanna, Parambir S Dulai, William J Sandborn, Vipul Jairath and Brian G Feagan.

in Journal of Crohn's and Colitis

January 2018; p ublished online September 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Gastroenterology; Epidemiology. 6879 words.

Abstract

Background and Aims

Crohn’s disease-related complications account for a substantial proportion of...

Ethical Issues in First-in-Human Phase I Cancer Trials

Elizabeth A. Eisenhauer.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 5275 words.

There are international and national standards addressing the ethical conduct of clinical trials and the protection of human subjects in research. This chapter highlights those ethical...

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Headache care, research and education worldwide

Edited by Jes Olesen and Nabih Ramadan.

May 2010; p ublished online November 2012 .

Book. Subjects: Neurology; Public Health and Epidemiology; Clinical Pharmacology and Therapeutics. 208 pages.

This resource brings the theme of a global campaign to the forefront. Researchers, scientists, and respected clinicians from around the world discuss aspects of access to care, individual...

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Introduction

Elizabeth A. Eisenhauer.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 2727 words.

Chapter 1 introduces core concepts behind Phase I Trials including the history of Phase I cancer trials, the process of developing new agents for cancer therapy, finding the recommended...

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malathion

Overview page. Subjects: Clinical Pharmacology and Therapeutics — Public Health and Epidemiology.

(mal-ă-th'y-on)

an organophosphorous insecticide used to treat head and pubic lice and scabies. It is applied externally in the form of a lotion or shampoo. Trade names: Derbac-M,...

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OSH Day Case Surgery

Edited by Ian Smith, Douglas McWhinnie and Ian Jackson.

P ublished online January 2012 .

Book. Subjects: Surgery; Peri-operative Care; Anaesthetics; Clinical Pharmacology and Therapeutics; Paediatric Surgery; Breast Surgery; Otolaryngology (ENT); Gynaecology; Trauma and Orthopaedic Surgery; Urology; Vascular Surgery; Nursing Skills; Medical Statistics and Methodology; Public Health; Patient Education and Information; Professional Development in Medicine. 448 pages.

This online guide provides the practising day surgery professional with a modern overview of current practice to act as both a reference and a practical guide to everyday challenges.

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Oxford Handbook of Paediatrics

Edited by Robert C. Tasker, Robert J. McClure and Carlo L. Acerini.

January 2013; p ublished online January 2013 .

Book. Subjects: Paediatrics; Public Health and Epidemiology; Epidemiology; Clinical Skills; Emergency Medicine; Neonatology; Cardiovascular Medicine; Respiratory Medicine and Pulmonology; Gastroenterology; Nephrology; Endocrinology and Diabetes; Neurology; Psychiatry; Haematology; Radiation Oncology; Infectious Diseases; Rheumatology; Trauma and Orthopaedic Surgery; Dermatology; Paediatric Surgery; Community Medical Services; Clinical Pharmacology and Therapeutics. 1120 pages.

This invaluable reference covers all significant aspects of acute and chronic paediatrics. Areas such as neonatology, surgery, genetics and congenital malformations and child protection are...

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Oxford Textbook of Palliative Medicine

Edited by Geoffrey Hanks, Nathan I. Cherny, Nicholas A. Christakis, Marie Fallon, Stein Kaasa and Russell K. Portenoy.

P ublished online March 2011 .

Book. Subjects: Palliative Medicine; History of Medicine; Pharmacology; Public Health and Epidemiology; Infectious Diseases; Epidemiology; Medical Statistics and Methodology; Medical Oncology; Medical Ethics; Nursing Skills; Occupational Therapy; Arts Therapies; Dietetics and Nutrition; Physiotherapy; Speech and Language Therapy; Clinical Pharmacology and Therapeutics; Paediatrics; Communication Skills; Clinical Science; Pain Medicine; Clinical Radiology; Interventional Radiology; Psychiatry; Gastroenterology; Dermatology; Genito-urinary Medicine; Endocrinology and Diabetes; Respiratory Medicine and Pulmonology; Neurology; Cardiovascular Medicine; Nephrology; Critical Care; Geriatric Medicine; Rehabilitation Medicine; Professional Development in Medicine. 1704 pages.

The Oxford Textbook of Palliative Medicine is the definitive textbook on the subject. The book is used across the world by the wide range of health care professionals involved in the care...

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Phase 0 Clinical Trials

Shivaani Kummar and James H. Doroshow.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 4640 words.

Phase 0 trials are first-in-human trials conducted under the US Food and Drug Administration’s Exploratory Investigational New Drug guidance. Such trials provide a platform to obtain human...

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Phase I Cancer Clinical Trials

Edited by Elizabeth A. Eisenhauer, Christopher Twelves and Marc Buyse.

March 2015; p ublished online May 2015 .

Book. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 368 pages.

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior...

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Phase I Trials in Special Populations and Circumstances

Kumar Rajiv, Twelves Chris and Banerji Udai.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 17295 words.

In the interests of safety, most phase 1 cancer trials are carried out in patients who fulfill strict criteria. These patients are not, therefore, representative of the patients treated in...

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Phase I Trials of Immunotherapeutics

Christy Ralph, Emma King, Chris Twelves and Christian Ottensmeier.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 7835 words.

As cancer immunotherapy is increasingly accepted as a treatment modality, the careful design of early phase as well as late phase clinical trials is critical to address their particular...

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Practical Aspects of Pharmacokinetics and Pharmacodynamics

Maria Jove and Paul Loadman.

Edited by Chris Twelves.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 18199 words.

Chapter 10 reviews pharmacokinetic and pharmacodynamic measures which play important roles in phase I trials of anticancer agents. Both require clear protocol specifications regarding what,...

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Preclinical Data and Requirements

Sophie Postel-Vinay and Jean-Charles Soria.

Edited by Elizabeth A. Eisenhauer.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 12084 words.

Chapter 2 is intended to guide investigators through some basic principles of preclinical evaluation. It is not expected that it will provide recipes for the conduct of preclinical studies...

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Process, Pitfalls, and Logistics of Phase I Trials

Elizabeth A. Eisenhauer, Chris Twelves, Hayley Farmer and Philip Ross.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 13571 words.

This chapter provides an overview of the many administrative and organizational steps that must be undertaken before a phase I trial may begin. It details the roles and responsibilities of...

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Reporting and Interpreting Results

Lesleigh S. Abbott and Lesley K. Seymour.

Edited by Elizabeth A. Eisenhauer.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 10408 words.

Although most of the literature regarding inadequate reporting of clinical trials has focused on later stage trials, with the creation of registries and mandatory reporting, phase I trials...

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Statistical Designs for First-in-Man Phase I Cancer Trials

Xavier Paoletti and Marc Buyse.

in Phase I Cancer Clinical Trials

March 2015; p ublished online May 2015 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Public Health and Epidemiology. 10858 words.

This chapters discusses the design of Phase I Cancer trials including models such as the “3+3” design, the Continual Reassessment Method, Escalation With Overdose Control (EWOC), Isotonic...

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