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Reproductive Medicine x Endocrinology and Diabetes x clear all

Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice

Lowenna J Holt, Amanda E Brandon, Lewin Small, Eurwin Suryana, Elaine Preston, Donna Wilks, Nancy Mokbel, Chantal A Coles, Jason D White, Nigel Turner, Roger J Daly and Gregory J Cooney.

in Endocrinology

P ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6668 words.

Abstract

Grb10 is an adaptor-type signaling protein most highly expressed in tissues involved in insulin action and glucose metabolism, such as muscle,...

The Absence of Laminin α4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue

Marcella K Vaicik, Alen Blagajcevic, Honggang Ye, Mallory C Morse, Feipeng Yang, Anna Goddi, Eric M Brey and Ronald N Cohen.

in Endocrinology

P ublished online July 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 8016 words.

Abstract

Laminin α4 (LAMA4) is located in the extracellular basement membrane that surrounds each individual adipocyte. Here we show that LAMA4 null (Lama4−/−null...

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ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice

Hiroyuki Takagi, Tatsuya Ikehara, Yuto Kashiwagi, Kumi Hashimoto, Isamu Nanchi, Atsuyuki Shimazaki, Hirohide Nambu and Hideo Yukioka.

in Endocrinology

P ublished online June 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 8054 words.

Abstract

Intramyocellular lipid (IMCL) accumulation in skeletal muscle greatly contributes to lipid-induced insulin resistance. Because acetyl-coenzyme A (CoA)...

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Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice

Marie-José Lecomte, Chloé Bertolus, Nélina Ramanantsoa, Françoise Saurini, Jacques Callebert, Catherine Sénamaud-Beaufort, Maud Ringot, Thomas Bourgeois, Boris Matrot, Corinne Collet, Jeannette Nardelli, Jacques Mallet, Guilan Vodjdani, Jorge Gallego, Jean-Marie Launay and Sylvie Berrard.

in Endocrinology

P ublished online March 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 10764 words.

Abstract

Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during...

ACTIVExtend: 24 Months of Alendronate After 18 Months of Abaloparatide or Placebo for Postmenopausal Osteoporosis

Henry G Bone, Felicia Cosman, Paul D Miller, Gregory C Williams, Gary Hattersley, Ming-yi Hu, Lorraine A Fitzpatrick, Bruce Mitlak, Socrates Papapoulos, René Rizzoli, Robin K Dore, John P Bilezikian and Kenneth G Saag.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online May 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5356 words.

Abstract

Purpose

In women with postmenopausal osteoporosis, we investigated the effects of 24 months of treatment...

Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE−/− Mice

Laura G Goetz, Ramanaiah Mamillapalli, Cagdas Sahin, Masoumeh Majidi-Zolbin, Guanghao Ge, Arya Mani and Hugh S Taylor.

in Endocrinology

P ublished online December 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 7060 words.

Abstract

The contributions of estradiol and testosterone to atherosclerotic lesion progression are not entirely understood. Cross-sex hormone therapy (XHT) for...

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Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance

Paul Petrus, Lucia Bialesova, Antonio Checa, Alastair Kerr, Shama Naz, Jesper Bäckdahl, Ana Gracia, Sofia Toft, Karin Dahlman-Wright, Per Hedén, Ingrid Dahlman, Craig E Wheelock, Peter Arner, Niklas Mejhert, Hui Gao and Mikael Rydén.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online November 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 7412 words.

Abstract

Context

Insulin resistance (IR) is promoted by a chronic low-grade inflammation in white adipose tissue...

Adipose Tissue Inflammation and Adrenomedullin Overexpression Contribute to Lipid Dysregulation in Diabetic Pregnancies

Yuanlin Dong, Madhu Chauhan, Ancizar Betancourt, Michael Belfort and Chandra Yallampalli.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online July 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5866 words.

Abstract

Context

Impaired maternal lipid metabolism in gestational diabetes mellitus (GDM) has detrimental effects...

The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms

William C Engeland, Logan Massman, Shubhendu Mishra, J Marina Yoder, Sining Leng, Emanuele Pignatti, Mary E Piper, Diana L Carlone, David T Breault and Paulo Kofuji.

in Endocrinology

P ublished online October 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 10207 words.

Abstract

The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by...

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Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro

Juilee Rege, Aya T Nanba, Richard J Auchus, Jianwei Ren, Hwei-Ming Peng, William E Rainey and Adina F Turcu.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online November 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6175 words.

Abstract

Background

Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulation, and...

The AKT/BCL-2 Axis Mediates Survival of Uterine Leiomyoma in a Novel 3D Spheroid Model

Vania Vidimar, Debabrata Chakravarti, Serdar E Bulun, Ping Yin, Romana Nowak, Jian-Jun Wei and J Julie Kim.

in Endocrinology

P ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5858 words.

Abstract

A deeper understanding of the pathways that drive uterine leiomyoma (ULM) growth and survival requires model systems that more closely mimic the in...

Aldosterone Is Not Associated With Metabolic and Microvascular Insulin Sensitivity in Abdominally Obese Men

Monica T J Schütten, Yvo H A M Kusters, Alfons J H M Houben, Jean L J M Scheijen, Marjo P H van de Waarenburg, Casper G Schalkwijk, Peter J Joris, Jogchum Plat, Ronald P Mensink, Peter W de Leeuw and Coen D A Stehouwer.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online December 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6429 words.

Abstract

Context

Impaired insulin-mediated muscle microvascular recruitment (IMMR) may add to the development of...

Alemtuzumab-Induced Thyroid Dysfunction Exhibits Distinctive Clinical and Immunological Features

Nadia Pariani, Mark Willis, Ilaria Muller, Sarah Healy, Taha Nasser, Anne McGowan, Greta Lyons, Joanne Jones, Krishna Chatterjee, Colin Dayan, Neil Robertson, Alasdair Coles and Carla Moran.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online June 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5132 words.

Abstract

Context

Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves...

Alendronate Use and the Risk of Nonvertebral Fracture During Glucocorticoid Therapy: A Retrospective Cohort Study

Jonathan Bergman, Anna Nordström and Peter Nordström.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online November 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5077 words.

Abstract

Context

Glucocorticoids increase the risk of nonvertebral fracture, but no clinical trial has shown that...

Altered Asparagine and Glutamate Homeostasis Precede Coronary Artery Disease and Type 2 Diabetes

Filip Ottosson, Einar Smith, Olle Melander and Céline Fernandez.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online May 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5215 words.

Abstract

Context

Type 2 diabetes mellitus (T2DM) is accompanied by an increased risk for coronary artery disease...

Altered Expression of miR-181a-5p and miR-23a-3p Is Associated With Obesity and TNFα-Induced Insulin Resistance

Javier Lozano-Bartolomé, Gemma Llauradó, Manel Portero-Otin, Antonio Altuna-Coy, Gemma Rojo-Martínez, Joan Vendrell, Rosa Jorba, Esther Rodríguez-Gallego and Matilde R Chacón.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online February 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6082 words.

Abstract

Context

The proinflammatory cytokine TNFα is a key player in insulin resistance (IR). The role of miRNAs...

Amino Acid and Fatty Acid Levels Affect Hepatic Phosphorus Metabolite Content in Metabolically Healthy Humans

Sabine Kahl, Bettina Nowotny, Klaus Strassburger, Alessandra Bierwagen, Birgit Klüppelholz, Barbara Hoffmann, Guido Giani, Peter J Nowotny, Franziska Wallscheid, Erifili Hatziagelaki, Giovanni Pacini, Jong-Hee Hwang and Michael Roden.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online November 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6604 words.

Abstract

Objective

Hepatic energy metabolism negatively relates to insulin resistance and liver fat content in...

Androgens, Irregular Menses, and Risk of Diabetes and Coronary Artery Calcification in the Diabetes Prevention Program

Catherine Kim, Vanita R Aroda, Ronald B Goldberg, Naji Younes, Sharon L Edelstein, MaryLou Carrion-Petersen and David A Ehrmann.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online December 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 8247 words.

Abstract

Context

It is unclear whether relative elevations in androgens or irregular menses (IM) are associated...

Anti–PD-L1 Treatment Induced Central Diabetes Insipidus

Chen Zhao, Sri Harsha Tella, Jaydira Del Rivero, Anuhya Kommalapati, Ifechukwude Ebenuwa, James Gulley, Julius Strauss and Isaac Brownell.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online December 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 2650 words.

Abstract

Context

Immune checkpoint inhibitors, including anti–programmed cell death protein 1 (PD-1),...

Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS

Genevieve E Ryan, Shaddy Malik and Pamela L Mellon.

in Endocrinology

P ublished online February 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 9016 words.

Abstract

Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and...