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Molecular and Cell Biology x Preclinical Medicine x Clinical Pharmacology and Therapeutics x clear all

Cardiac surgery-associated acute kidney injury: risk factors analysis and comparison of prediction models

Darko Kristovic, Ivica Horvatic, Ino Husedzinovic, Zeljko Sutlic, Igor Rudez, Davor Baric, Daniel Unic, Robert Blazekovic and Matija Crnogorac.

in Interactive CardioVascular and Thoracic Surgery

September 2015; p ublished online June 2015 .

Journal Article. Subjects: Research Methods in Life Sciences; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 5765 words.

OBJECTIVES

Cardiac surgery-associated acute kidney injury (AKI) is a well-known factor influencing patients' long-term morbidity and mortality. Several...

Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes

Uwe M. Fischer, Oliver Klass, Ulrike Stock, Jerry Easo, Hans J. Geissler, Juergen H. Fischer, Wilhelm Bloch and Uwe Mehlhorn.

in European Journal of Cardio-Thoracic Surgery

June 2003; p ublished online June 2003 .

Journal Article. Subjects: Cardiothoracic Surgery; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 3332 words.

Objective: Myocardial ischemia–reperfusion is associated with free radical-mediated injury and may be involved in cardiac apoptosis. The purpose of our study was to investigate...

Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated β-adrenergic signaling modulation

Hendrik T. Tevaearai, G. Brant Walton, Andrea D. Eckhart, Janelle R. Keys and Walter J. Koch.

in European Journal of Cardio-Thoracic Surgery

November 2002; p ublished online November 2002 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Transplant Surgery; Molecular Biology and Genetics. 2991 words.

Objectives: Reperfusion after myocardial ischemia goes together with alteration of the β-adrenergic (βAR) signaling. Especially the level and catalytic activity of β AR kinase...

Double giant coronary aneurysm: improved morphological study by computed tomography

Adrien Pasteur-Rousseau, Erik Bouvier, Patrick Donzeau-Gouge and Xavier Troussier.

in Interactive CardioVascular and Thoracic Surgery

October 2014; p ublished online July 2014 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular Biology and Genetics; Molecular and Cell Biology. 1193 words.

Coronary artery aneurysm may cause coronary artery rupture, thromboembolism or haemodynamic problems related to compression. We report the case of a 68-year old man who was referred to an...

The effects of preoperative statins on the incidence of postoperative acute kidney injury in patients undergoing cardiac surgeries

Mohammad Hassan Nemati and Behrooz Astaneh.

in Interactive CardioVascular and Thoracic Surgery

October 2015; p ublished online July 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Professional Development in Medicine; Molecular and Cell Biology; Cardiovascular Medicine; Cardiothoracic Surgery; Molecular Biology and Genetics. 3742 words.

OBJECTIVES

Recent evidence has emphasized multifunctional therapeutic effects of statins on renal protection after cardiac surgeries. We aimed to assess the...

Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium

Munir Boodhwani, Jun Feng, Shigetoshi Mieno, Basel Ramlawi, Neel Sodha, Richard Clements and Frank W. Sellke.

in European Journal of Cardio-Thoracic Surgery

May 2006; p ublished online May 2006 .

Journal Article. Subjects: Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Surgery; Clinical Pharmacology and Therapeutics; Molecular Biology and Genetics. 3889 words.

Objective: Vascular occlusion during off-pump coronary surgery often results in sub-optimal visualization and endothelial damage of the target vessel. We have previously...

Enhancement of Na+,K+-ATPase and Ca2+-ATPase activities in multi-cycle ischemic preconditioning in rabbit hearts

Toshihiro Yorozuya, Naoto Adachi, Kentaro Dote, Kazuo Nakanishi, Yasushi Takasaki and Tatsuru Arai.

in European Journal of Cardio-Thoracic Surgery

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Clinical Pharmacology and Therapeutics; History of Medicine; Molecular Biology and Genetics. 3517 words.

Objective: Ischemic preconditioning (IP) has been shown to attenuate intracellular Na+ accumulation and Ca2+ overload during ischemia and reperfusion, both of which are closely...

Fusion of bone marrow-derived stem cells with cardiomyocytes in a heterologous in vitro model

Jens Garbade, Andreas Schubert, Ardawan Julian Rastan, Dominik Lenz, Thomas Walther, Jan Fritz Gummert, Stefan Dhein and Friedrich-Wilhelm Mohr.

in European Journal of Cardio-Thoracic Surgery

November 2005; p ublished online November 2005 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Transplant Surgery; Molecular Biology and Genetics. 5250 words.

Objective: Recent studies have demonstrated that transplanted bone marrow-derived stem cells (BMCs) possess a broad differentiation potential and are able to form new...

Heat shock protein, inducible nitric oxide synthase and apoptotic markers in the acute phase of human cardiac transplantation

Serban C. Stoica, Duwarakan K. Satchithananda, Carl Atkinson, Susan Charman, Martin Goddard and Stephen R. Large.

in European Journal of Cardio-Thoracic Surgery

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Transplant Surgery; Molecular Biology and Genetics. 3916 words.

Objective: Solid organ transplantation is associated with activation of apoptotic pathways and other stress markers. We aimed to describe the expression of Bax, Bcl-2, iNOs and...

In vivo model for cross-species porcine endogenous retrovirus transmission using tissue engineered pulmonary arteries

Thorsten Walles, Arthur Lichtenberg, Carmen Puschmann, Rainer Leyh, Mathias Wilhelmi, Klaus Kallenbach, Axel Haverich and Heike Mertsching.

in European Journal of Cardio-Thoracic Surgery

September 2003; p ublished online September 2003 .

Journal Article. Subjects: Anatomy; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 2805 words.

Objective: Acellularised porcine scaffolds have been successfully used for cardiovascular tissue engineering. However, there is concern about the possibility of porcine...

Mitochondrial DNA deletions in coronary artery bypass grafting patients

Sidney Levitsky, Jari Laurikka, Robert D. Stewart, Christian T. Campos, Steven J. Lahey and James D. McCully.

in European Journal of Cardio-Thoracic Surgery

November 2003; p ublished online November 2003 .

Journal Article. Subjects: Anatomy; Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Clinical Pharmacology and Therapeutics; History of Medicine; Molecular Biology and Genetics. 4093 words.

Objective: Mitochondrial DNA (mitoDNA) deletions have been shown to increase with aging and ischemia and have been suggested to contribute to myocardial dysfunction. The...

Mitral valve repair of isolated posterior leaflet prolapse: resect or respect?

Christos Tourmousoglou, Spiros Lalos and Dimitrios Dougenis.

in Interactive CardioVascular and Thoracic Surgery

December 2014; p ublished online September 2014 .

Journal Article. Subjects: Cardiothoracic Anaesthesia; Cardiothoracic Surgery; Professional Development in Medicine; Molecular and Cell Biology; Surgical Oncology; Cardiovascular Medicine; Gastroenterology; Clinical Pharmacology and Therapeutics; Molecular Biology and Genetics. 4479 words.

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether it is best in a patient with posterior leaflet prolapse to resect...

A predictive scoring system for deep sternal wound infection after bilateral internal thoracic artery grafting

Giuseppe Gatti, Luca Dell'Angela, Giulia Barbati, Bernardo Benussi, Gabriella Forti, Marco Gabrielli, Elisabetta Rauber, Roberto Luzzati, Gianfranco Sinagra and Aniello Pappalardo.

in European Journal of Cardio-Thoracic Surgery

March 2016; p ublished online June 2015 .

Journal Article. Subjects: Respiratory Medicine and Pulmonology; Anatomy; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular Biology and Genetics; Molecular and Cell Biology. 5863 words.

OBJECTIVES

Despite long-term survival benefits, the increased risk of sternal complications limits the use of bilateral internal thoracic artery (BITA)...

A randomized study comparing traditional monofilament knotted sutures with barbed knotless sutures for donor leg wound closure in coronary artery bypass surgery

Bhuvaneswari Krishnamoorthy, Niamh Shepherd, William R. Critchley, Janesh Nair, Nehru Devan, Abdul Nasir, James B. Barnard, Rajamiyer V. Venkateswaran, Paul D. Waterworth, James E. Fildes and Nizar Yonan.

in Interactive CardioVascular and Thoracic Surgery

February 2016; p ublished online November 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular Biology and Genetics; Molecular and Cell Biology. 4028 words.

OBJECTIVES

Surgical knots on the suture line provide an anchoring function, but also represent a potential source of infection and irritation on the donor...

Restoration of sarcoplasmic reticulum protein level by thyroid hormone contributes to partial improvement of myocardial function, but not to glucose metabolism in an early failing heart

Masahito Minakawa, Koh Takeuchi, Kazuo Ito, Takao Tsushima, Kozo Fukui, Shunichi Takaya and Ikuo Fukuda.

in European Journal of Cardio-Thoracic Surgery

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Surgery; Clinical Pharmacology and Therapeutics; Molecular Biology and Genetics. 5091 words.

Objective: In heart failure, sarcoplasmic reticulum Ca2+-ATPase (SERCA2) activity is decreased, resulting in abnormal Ca2+ handling and contractile dysfunction. We have...

RNase1 as a potential mediator of remote ischaemic preconditioning for cardioprotection

Hector A. Cabrera-Fuentes, Bernd Niemann, Philippe Grieshaber, Matthias Wollbrueck, Johannes Gehron, Klaus T. Preissner and Andreas Böning.

in European Journal of Cardio-Thoracic Surgery

November 2015; p ublished online January 2015 .

Journal Article. Subjects: Cardiothoracic Surgery; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 3961 words.

OBJECTIVES

Remote ischaemic preconditioning (RIPC) is a non-invasive and virtually cost-free strategy for protecting the heart against acute...

Routine use of bilateral internal thoracic artery grafts for left-sided myocardial revascularization in insulin-dependent diabetic patients: early and long-term outcomes

Giuseppe Gatti, Petar Soso, Luca Dell'Angela, Luca Maschietto, Lorella Dreas, Bernardo Benussi, Roberto Luzzati, Gianfranco Sinagra and Aniello Pappalardo.

in European Journal of Cardio-Thoracic Surgery

July 2015; p ublished online September 2014 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Respiratory Medicine and Pulmonology; Molecular and Cell Biology; Cardiovascular Medicine; Anatomy; Molecular Biology and Genetics. 4480 words.

OBJECTIVES

Despite encouraging late outcomes, the use of bilateral internal thoracic artery (BITA) grafting for myocardial revascularization in diabetic...

Vasomotor dysfunction after cardiac surgery

Marc Ruel, Tanveer A. Khan, Pierre Voisine, Cesario Bianchi and Frank W. Sellke.

in European Journal of Cardio-Thoracic Surgery

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Cardiothoracic Surgery; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 7330 words.

Cardiopulmonary bypass and cardioplegic arrest, which allow for support of the circulation and stabilization of the heart during cardiac procedures, are still used for the vast majority of...

Who might benefit from early aspirin after coronary artery surgery?

Philemon Gukop, Nadav Gutman, Rajdeep Bilkhu and Georgios T. Karapanagiotidis.

in Interactive CardioVascular and Thoracic Surgery

September 2014; p ublished online May 2014 .

Journal Article. Subjects: Professional Development in Medicine; Cardiothoracic Surgery; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular Biology and Genetics; Molecular and Cell Biology. 3301 words.

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether early administration of aspirin might optimize vein graft...

β2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery

J. Mark Jones, Jason A. Petrofski, Katrina H. Wilson, Charles Steenbergen, Walter J. Koch and Carmelo A. Milano.

in European Journal of Cardio-Thoracic Surgery

December 2004; p ublished online December 2004 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 4693 words.

Objective: Heart surgery is associated with impairment of the myocardial β-adrenoceptor (βAR) system. Effective therapies for post-operative ventricular dysfunction are...