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3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM

Eugene Y.D. Chua, Vinod K. Vogirala, Oviya Inian, Andrew S.W. Wong, Lars Nordenskiöld, Juergen M. Plitzko, Radostin Danev and Sara Sandin.

in Nucleic Acids Research

September 2016; p ublished online August 2016 .

Journal Article. Subjects: Molecular and Cell Biology; Genetics and Genomics; Research Methods in Life Sciences; Proteins; Molecular Biology and Genetics. 3716 words.

The Volta phase plate is a recently developed electron cryo-microscopy (cryo-EM) device that enables contrast enhancement of biological samples. Here we have evaluated the potential of...

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The A1298C Mutation in Methylenetetrahydrofolate Reductase Gene and Its Association With Idiopathic Venous Thrombosis in an Iranian Population

Mohammad Soleyman Soltanpour, Zahra Soheili, Ali Akbar Pourfathollah, Shahram Samiei, Reza Meshkani, Ali Asghar Kiani, Safa Majid, Zahra Ataei and Mahnaz Kavari.

in Laboratory Medicine

April 2011; p ublished online October 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cell Biology; Molecular Biology and Genetics. 2806 words.

Background:

Venous thrombosis (VT) is an important cause of mortality and morbidity resulting from acquired and inherited factors. The A1298C mutation of the...

ABA Regulates Subcellular Redistribution of OsABI-LIKE2, a Negative Regulator in ABA Signaling, to Control Root Architecture and Drought Resistance in Oryza sativa

Chengxiang Li, Hongyun Shen, Tao Wang and Xuelu Wang.

in Plant and Cell Physiology

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Molecular Biology and Genetics; Biotechnology; Biochemistry; Bioinformatics and Computational Biology; Molecular and Cell Biology; Plant Sciences and Forestry; Plant Physiology. 8295 words.

The phytohormone ABA is a key stress signal in plants. Although the identification of ABA receptors led to significant progress in understanding the Arabidopsis ABA signaling pathway, there...

ABCA1 and ABCG1 Expression in the Small Intestine of Type 2 Diabetic Rats

Juanya Lou, Huali Zhou, Chengjiang Li, Lingling Hu, Xunliang Lu, Jun Li, Hongtian Yao, Wenpeng Li, Xinxin Zhang and Mingzhi Xu.

in Laboratory Medicine

February 2014; p ublished online September 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cell Biology; Molecular Biology and Genetics. 3625 words.

Objective

Inflammation of the small intestine may occur in type 2 diabetes. This study aimed to investigate whether ATP-binding cassette transporter A1...

Abscisic Acid Participates in the Control of Cell Cycle Initiation Through Heme Homeostasis in the Unicellular Red Alga Cyanidioschyzon merolae

Yuki Kobayashi, Hiroyuki Ando, Mitsumasa Hanaoka and Kan Tanaka.

in Plant and Cell Physiology

May 2016; p ublished online April 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biotechnology; Biochemistry; Bioinformatics and Computational Biology; Molecular and Cell Biology; Plant Sciences and Forestry; Plant Physiology. 5053 words.

ABA is a phytohormone that is synthesized in response to abiotic stresses and other environmental changes, inducing various physiological responses. While ABA has been found in unicellular...

Absence of TLR4 Asp299Gly and Thr399Ile Polymorphisms in Chinese Han Population With Type 2 Diabetes

Peng-bin Lai, Lei Zhang, Sun-jie Yan and Li-yong Yang.

in Laboratory Medicine

September 2010; p ublished online October 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cell Biology; Molecular Biology and Genetics. 1715 words.

Objective:

This study was performed to detect the association between the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene and type 2 diabetes in the...

Absolute Quantitation of Different Genotypes of Hepatitis C Virus RNA in Clinical Samples by a Modified Real-Time PCR Method

Karina del Carmen Trujillo-Murillo, Diana Cristina Pérez-Ibave, Clara Patricia Ríos-Ibarra, Eda Guadalupe Ramirez-Valles, Ana Rosa Rincón-Sánchez and Ana María Rivas-Estilla.

in Laboratory Medicine

June 2011; p ublished online October 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cell Biology; Molecular Biology and Genetics. 2425 words.

Background:

Our aim was to develop a quantitative real-time polymerase chain reaction (qPCR) assay for the quantitation of hepatitis C virus (HCV) RNA...

Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β

Mizuki Yamamoto, Ryohei Yamamoto, Shigeo Takenaka, Satoshi Matsuyama and Kihei Kubo.

in Journal of Radiation Research

July 2015; p ublished online March 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4559 words.

In mammalian cells, murine N-methylpurine DNA glycosylase (MPG) removes bases damaged spontaneously or by chemical agents through the process called base excision repair (BER). In this...

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Accelerated acute severe antibody-mediated graft failure related to a Ross procedure 17 years earlier

Martin Andreas, Kathrin Freystaetter, Martin H Bernardi and Andreas Zuckermann.

in European Journal of Cardio-Thoracic Surgery

August 2018; p ublished online February 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Molecular and Cell Biology; Transplant Surgery; Cardiovascular Medicine. 749 words.

Abstract

A 31-year-old male patient underwent a heart transplantation due to dilated cardiomyopathy. He experienced accelerated acute antibody-mediated...

Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury

Elizabeth A McCart, Rajesh L Thangapazham, Eric D Lombardini, Steven R Mog, Ronald Allan M Panganiban, Kelley M Dickson, Rihab A Mansur, Vitaly Nagy, Sung-Yop Kim, Reed Selwyn, Michael R Landauer, Thomas N Darling and Regina M Day.

in Journal of Radiation Research

September 2017; p ublished online March 2017 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 6543 words.

Abstract

Accidental high-dose radiation exposures can lead to multi-organ injuries, including radiation dermatitis. The types of cellular damage leading to...

Accurate ab initio prediction of NMR chemical shifts of nucleic acids and nucleic acids/protein complexes

Andrea Victora, Heiko M. Möller and Thomas E. Exner.

in Nucleic Acids Research

December 2014; p ublished online November 2014 .

Journal Article. Subjects: Molecular and Cell Biology; Proteins; Molecular Biology and Genetics. 7813 words.

NMR chemical shift predictions based on empirical methods are nowadays indispensable tools during resonance assignment and 3D structure calculation of proteins. However, owing to the very...

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The ACE I/D Polymorphism in US Adults: Limited Evidence of Association With Hypertension-Related Traits and Sex-Specific Effects by Race/Ethnicity

Renée M. Ned, Ajay Yesupriya, Giuseppina Imperatore, Diane T. Smelser, Ramal Moonesinghe, Man-Huei Chang and Nicole F. Dowling.

in American Journal of Hypertension

February 2012; p ublished online February 2012 .

Journal Article. Subjects: Genetics and Genomics; Molecular Biology and Genetics. 4427 words.

Background:

The insertion/deletion (I/D) variant (rs4646994) of the angiotensin I-converting enzyme (ACE) gene is one of the most studied polymorphisms in...

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Acquisition of radioresistance by IL-6 treatment is caused by suppression of oxidative stress derived from mitochondria after γ-irradiation

Yuki Tamari, Genro Kashino and Hiromu Mori.

in Journal of Radiation Research

July 2017; p ublished online February 2017 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4631 words.

Abstract

Interleukin (IL)-6 is a multifunctional cytokine and is one of the radiation-induced bystander factors. This study aimed to clarify the mechanism of...

Acquisition-weighted MRSI for Detection and Quantification of BNCT 10B-carrier L-p-boronophenylalanine-fructose Complex, a Phantom Study

Marjut Timonen, Leena Kankaanranta, Nina Lundbom, Mika Kortesniemi, Tiina SeppäLä, Mauri Kouri, Sauli Savolainen and Sami Heikkinen.

in Journal of Radiation Research

September 2009; p ublished online July 2009 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 0 words.

Proton magnetic resonance spectroscopy (1H MRS) is a potential method to detect and quantify a boron neutron capture therapy 10B-carrier compound, L-p-boronophenylalanine (BPA), in the...

Activation of DC-SIGN Promoter and Common Signaling Pathways Between HIV-1 5′LTR and DC-SIGN

Changzhong Jin, Lijuan Wu, Jie Li, Linfang Cheng, Juan Wang and Nanping Wu.

in Laboratory Medicine

May 2013; p ublished online September 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cell Biology; Molecular Biology and Genetics. 2197 words.

Objective:

To explore whether expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and reactivation of...

Acute urinary morbidity after a permanent 125I implantation for localized prostate cancer

Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Katsunori Tatsugami, Tomonari Sasaki, Takeshi Nonoshita, Tadamasa Yoshitake, Kaori Asai, Hideki Hirata, Seiji Naito and Hiroshi Honda.

in Journal of Radiation Research

November 2014; p ublished online July 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 2912 words.

We evaluated the predictive factors of acute urinary morbidity (AUM) after prostate brachytherapy. From November 2005 to January 2007, 62 patients with localized prostate cancer were...

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Adaptation to the Local Environment by Modifications of the Photoperiod Response in Crops

Norihito Nakamichi.

in Plant and Cell Physiology

April 2015; p ublished online November 2014 .

Journal Article. Subjects: Molecular Biology and Genetics; Biotechnology; Biochemistry; Bioinformatics and Computational Biology; Molecular and Cell Biology; Plant Sciences and Forestry; Plant Physiology. 7373 words.

Flowering plants produce a meristem at the shoot tip where specialized tissue generates shoot apical meristems at the appropriate time to differentiate into reproductive structures,...

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Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes

Lucia Greenough, Kelly M. Schermerhorn, Laurie Mazzola, Joanna Bybee, Danielle Rivizzigno, Elizabeth Cantin, Barton E. Slatko and Andrew F. Gardner.

in Nucleic Acids Research

January 2016; p ublished online September 2015 .

Journal Article. Subjects: Enzymology; Molecular Biology and Genetics. 6454 words.

Detailed biochemical characterization of nucleic acid enzymes is fundamental to understanding nucleic acid metabolism, genome replication and repair. We report the development of a rapid,...

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Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography

Toshihiko INOUE, Norihisa MASAI, Ryoong-Jin OH, Hiroya SHIOMI and Noriyasu HASHIDA.

in Journal of Radiation Research

May 2014; p ublished online April 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 2837 words.

Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for...

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Addressing the challenge of proper delineation of lymph node stations in modern radiotherapy for lung cancer

Lucyna Kępka and Joanna Socha.

in Journal of Radiation Research

July 2018; p ublished online March 2018 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 1482 words.

Abstract

We greatly appreciate the recent publication of a Japan Lung Cancer Society and Japanese Society for Radiation Oncology consensus-based computed...