Journal Article

Isopentenyl Pyrophosphate-Reactive Vγ9Vδ2 T Helper 1-Like Cells Are the Major γδ T Cell Subset Recovered from Lesions of Patients with Genital Herpes

Georges M. G. M. Verjans, R. Wim Roest, Alex van der Kooi and Albert D. M. E. Osterhaus

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 190, issue 3, pages 489-493
Published in print August 2004 | ISSN: 0022-1899
Published online August 2004 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1086/422393

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Herpes simplex virus (HSV)-specific T cells are essential to control and resolve genital herpes (GH). To investigate the potential involvement of gd T cells in GH, T cells were recovered and expanded, by mitogenic stimulation, to T cell lines from the genital lesions of 17 patients with GH and 5 control subjects who had other diseases. Relatively high numbers of γδ T cells—predominantly, Vγ9Vδ2 T cells—were detected only in the T cell lines of the patients with GH. Intralesional Vγ9Vδ2 T cell clones did not recognize HSV-infected cells, but they showed reactivity to isopentenyl pyrophosphate and Daudi cells. The T cell clones secreted interferon-γ, tumor necrosis factor-α, interleukin (IL)-8, macrophage inflammatory protein-1α, and RANTES (regulated on activation, normally T cell expressed or secreted), but they secreted no or limited IL-4. The results of the present study suggest the infiltration and putative involvement of isopentenyl pyrophosphate- reactive Vγ9Vδ2 T helper 1-like cells in individuals with GH.

Journal Article.  2828 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology