Assembly and targeting of voltage-dependent calcium channels

Annette C. Dolphin

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI:

Series: Molecular and Cellular Neurobiology Series

Assembly and targeting of voltage-dependent calcium channels

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Ion channel trafficking, like that of other heteromeric membrane proteins, proceeds in a number of stages, and in the case of voltage-dependent calcium channels (VDCCs) very little is known about any of these processes. Starting from the initial translation of subunit mRNA into protein, a number of distinct but interdependent processes must occur, including the translocation of transmembrane subunits into the membrane of the endoplasmic reticulum, post-translational modification and the folding of individual subunits, oligomerization and association with auxiliary subunits, and trafficking through the endoplasmic reticulum and trans-Golgi network. All these are likely to occur on overlapping timescales, and are not expected to be independent processes.

Keywords: VDCCs; ion channel trafficking; subunit mRNA; translation; oligomerization; translocation; transmembrane subunits

Chapter.  15094 words.  Illustrated.

Subjects: Neuroscience

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