Pharmacological augmentation strategies for depression

Roger S. McIntyre and Jay Nathanson

in Severe Depression

Published on behalf of Oxford University Press

Published in print February 2010 | ISBN: 9780199570249
Published online May 2011 | e-ISBN: 9780191740350 | DOI:

Series: Oxford Psychiatry Library

Pharmacological augmentation strategies for depression

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The best proven augmentation strategy in MDD is with the use of second-generation antipsychotics (SGAs, “atypicals”)

Several SGAs have received US FDA approval for the treatment of MDD when antidepressant monotherapy is insufficient and/or in treatment resistant populations, but there are likely efficacy differences across SGAs.

Available evidence suggests that SGAs offer a robust antidepressant effect in individuals with severe phenotypes of MDD.

Chapter.  1779 words. 

Subjects: Psychiatry

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