• Cardiovascular disease is a common cause of morbidity and mortality in people with type 2 diabetes. Some guidelines define diabetes as a coronary heart disease equivalent, requiring multiple cardiovascular risk factor reduction • The treatment of hyperglycaemia in type 2 diabetes reduces cardiovascular events, and on long-term follow up reduces cardiovascular and total mortality. Metformin and pioglitazone have advantages in subgroups of patients • There is a large evidence base for the treatment of hypertension in people with type 2 diabetes, using multiple antihypertensive drugs, and for the use of statins. The results of studies of other lipid-regulating drugs have been disappointing • Benefits of other methods to reduce cardiovascular risk, such as antiplatelet drugs and antioxidants, have yet to be established in people with type 2 diabetes.
‘Diabetes is a state of premature cardiovascular death which is associated with chronic hyperglycaemia and may also be associated with blindness and renal failure.’ Miles Fisher, British Diabetic Association meeting Dublin, 1996.
Chapter. 4255 words. Illustrated.
Subjects: Endocrinology and Diabetes
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