Clinical features of calcium pyrophosphate crystal deposition

Abhishek Abhishek and Michael Doherty

in Oxford Textbook of Osteoarthritis and Crystal Arthropathy

Third edition

Published on behalf of Oxford University Press

Published in print October 2016 | ISBN: 9780199668847
Published online November 2016 | e-ISBN: 9780191807176 | DOI:

Series: Oxford Textbooks in Rheumatology

Clinical features of calcium pyrophosphate crystal deposition

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Calcium pyrophosphate deposition (CPPD) occurs in the elderly, and is commonly asymptomatic. However, it can cause acute calcium pyrophosphate (CPP) crystal arthritis, chronic CPP crystal inflammatory arthritis, and is frequently present in joints with osteoarthritis (OA). Acute CPP crystal arthritis presents with rapid onset of acute synovitis, which frequently affects the knees, wrists, shoulders, and elbows. It can mimic sepsis in the elderly, and may require hospital admission. Patients with CPPD plus OA may have more inflammatory signs and symptoms (e.g. joint swelling, stiffness) than those with OA alone. Additionally, patients with CPPD plus OA may also have intermittent attacks of acute CPP crystal arthritis. Some patients with CPPD may have more chronic inflammatory joint involvement and are classified as chronic CPP crystal inflammatory arthritis. This chapter describes the clinical features and differential diagnosis of common clinical manifestations of CPPD and outlines some of its rarer manifestations.

Chapter.  3122 words.  Illustrated.

Subjects: Rheumatology

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