Journal Article

Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients

Ingrid Mai, Elke Störmer, Steffen Bauer, Hagen Krüger, Klemens Budde and Ivar Roots

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 18, issue 4, pages 819-822
Published in print April 2003 | ISSN: 0931-0509
Published online April 2003 | e-ISSN: 1460-2385 | DOI: https://dx.doi.org/10.1093/ndt/gfg002
Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients

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Background. This study investigated the effect of St John's wort (SJW) extract on the pharmacokinetics of the immunosuppressants tacrolimus (TAC) and mycophenolic acid (MPA).

Methods. Ten stable renal transplant patients received 600 mg SJW extract for 14 days in addition to their regular regimen of TAC and mycophenolate mofetil.

Results. Dose‐corrected AUC(0–12) of TAC decreased significantly from 180 ng/ml/h at baseline to 75.9 ng/ml/h after 2 weeks of SJW treatment. To maintain therapeutic TAC concentrations, dose adjustments from a median 4.5 mg/day at baseline to...

Keywords: drug interaction; immunosuppression; mycophenolic acid; St John's wort; tacrolimus; transplantation

Journal Article.  1957 words.  Illustrated.

Subjects: Nephrology

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