Journal Article

Different Sets of Translesion Synthesis DNA Polymerases Protect From Genome Instability Induced by Distinct Food-Derived Genotoxins

Piya Temviriyanukul, Matty Meijers, Sandrine van Hees-Stuivenberg, Jan J. W. A. Boei, Frédéric Delbos, Haruo Ohmori, Niels de Wind and Jacob G. Jansen

in Toxicological Sciences

Volume 127, issue 1, pages 130-138
Published in print May 2012 | ISSN: 1096-6080
Published online February 2012 | e-ISSN: 1096-0929 | DOI: https://dx.doi.org/10.1093/toxsci/kfs074
Different Sets of Translesion Synthesis DNA Polymerases Protect From Genome Instability Induced by Distinct Food-Derived Genotoxins

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DNA lesions, induced by genotoxic compounds, block the processive replication fork but can be bypassed by specialized translesion synthesis (TLS) DNA polymerases (Pols). TLS safeguards the completion of replication, albeit at the expense of nucleotide substitution mutations. We studied the in vivo role of individual TLS Pols in cellular responses to benzo[a]pyrene diolepoxide (BPDE), a polycyclic aromatic hydrocarbon, and 4-hydroxynonenal (4-HNE), a product of lipid peroxidation. To this aim, we used mouse embryonic fibroblasts with targeted disruptions in the TLS-associated Pols η, ι, κ, and...

Keywords: translesion synthesis DNA polymerases; benzo[a]pyrene diolepoxide; 4-hydroxynonenal; DNA damage bypass; double-stranded DNA breaks

Journal Article.  5328 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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