A conserved protein family originally identified as alternatively spliced products of the ld (limb deformity) locus of the mouse, mutations in which disrupt pattern formation, cause limb deformities and renal aplasia. Formins are involved in regulating actin and microtubule networks, signalling to the nucleus and in embryonic development. A characteristic feature are the formin homology domains (FH1 and FH2) that cooperate in rapidly assembling profilin–actin into long filaments although binding to microtubules involves other regions. Mammalian formins are mDia1 and mDia2. See diaphanous-related formins.
Subjects: Medicine and Health — Chemistry.