Oxford Index Search Results

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FUS-ERG gene fusion in isolated myeloid sarcoma showing uncommon clinical features

Ryosuke Ueda, Dai Maruyama, Junko Nomoto, Akiko M. Maeshima, Suguru Fukuhara, Hideaki Kitahara, Ken-ichi Miyamoto, Wataru Munakata, Tatsuya Suzuki, Hirokazu Taniguchi, Yukio Kobayashi and Kensei Tobinai.

in Oxford Medical Case Reports

P ublished online January 2016 .

Journal Article. Subjects: Haematology; Medical Oncology. 1791 words.

FUS-ERG gene fusion has not been reported in cases of myeloid sarcoma (MS), a subtype of acute myeloid leukemia involving extramedullary anatomic sites. Here, we report a case...

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Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma

Aurélie Bruno, Karim Labreche, Maïlys Daniau, Blandine Boisselier, Guillaume Gauchotte, Louis Royer-Perron, Amithys Rahimian, Frédéric Lemoine, Pierre de la Grange, Justine Guégan, Franck Bielle, Marc Polivka, Clovis Adam, David Meyronet, Dominique Figarella-Branger, Chiara Villa, Fabrice Chrétien, Sandrine Eimer, Frédéric Davi, Audrey Rousseau, Caroline Houillier, Carole Soussain, Karima Mokhtari, Khê Hoang-Xuan and Agusti Alentorn.

in Neuro-Oncology

July 2018; p ublished online February 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 4815 words.

Abstract

Background

Primary central nervous system lymphoma (PCNSL) represents a particular entity within...

KIAA1549:BRAF FUSION GENE IN PEDIATRIC BRAIN TUMORS OF DIFFERENT HISTOGENESIS

Felice Giangaspero, Manila Antonelli, Manuela Badiali, Francesca R. Buttarelli, Loredana Moi and Marc Sanson.

in Neuro-Oncology

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: The KIAA1549:BRAF fusion (K-B fusion) gene has been considered a driver genetic events and a useful diagnostic marker in pilocytic astrocytomas (PA). However B-K gene fusion has...

C11ORF95-RELA FUSIONS DRIVE ONCOGENIC NF-KB SIGNALING IN EPENDYMOMA

Richard Gilbertson, Matthew Parker, Kumarasamypet M. Mohankumar, Chandanamali Punchihewa, Ricardo Weinlich, James D. Dalton, Yongjin Li, Ryan Lee, Ruth G. Tatevossian, Timothy N. Phoenix, Radhika Thiruvenkatam, Elsie White, Bo Tang, Wilda Orisme, Kirti Gupta, Michael Rusch, Xiang Chen, Yuxin Li, Panduka Nagahawhatta, Erin Hedlund, David Finkelstein, Gang Wu, Sheila Shurtleff, John Easton, Kristy Boggs, Donald Yergeau, Bhavin Vadodaria, Heather L. Mulder, Jared Becksford, Pankaj Gupta, Robert Huether, Jing Ma, Guangchun Song, Amar Gajjar, Thomas Merchant, Frederick Boop, Amy A Smith, Li Ding, Charles Lu, Kerri Ochoa, David Zhao, Robert S. Fulton, Lucinda L. Fulton, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Douglas R. Green, Jinghui Zhang, David W. Ellison and Richard J. Gilbertson.

in Neuro-Oncology

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: The nuclear factor-kB (NF-kB) family of transcriptional regulators are central mediators of the cellular inflammatory response. Although constitutive NF-kB signaling is present...

P04.78 Ultrarapid FGFR3 immunostaining for diagnosis of gliomas harboring FGFR3 gene fusions

S Mäntylä, J Haapasalo, J Ilvesaro, K Nordfors, J Isola, H Haapasalo, M Nykter and K Granberg.

in Neuro-Oncology

September 2018; p ublished online September 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Background

Fibroblast growth factor receptor 3 (FGFR3) gene fusion with transforming acidic coiled coil 3...

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181

Gallen B. Triana-Baltzer, Rebecca L. Sanders, Maria Hedlund, Kellie A. Jensen, Laura M. Aschenbrenner, Jeffrey L. Larson and Fang Fang.

in Journal of Antimicrobial Chemotherapy

January 2011; p ublished online November 2010 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7713 words.

Background

Influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of...

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EPEN-25. KANSL1 GAIN AND FUSION - A NOVEL ALTERATION IN CHILDHOOD EPENDYMOMA

Yulia Margolin-Miller, Helen Toledano, Lital Sela-Tzuriano, Michal Hameiri-Grossman, Shalom Michowiz, Suzanna Fichman-Horn, Meora Feinmesser, Stefan Pfister, Hendrik Witt, Isaac Yaniv and Smadar Avigad.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Ependymoma is a malignant pediatric brain tumor, often incurable with current treatment regimens. We aimed to identify new genes involved in pediatric...

P04.01RELA FUSION DEFINES CLINICOPATHOLOGIC SUBSETS OF SUPRATENTORIAL EPENDYMOMA: A STUDY FROM THE COLLABORATIVE EPENDYMOMA RESEARCH NETWORK

K. Wani, E. Vera-Bolanos, T. Armstrong, S. Pfister, D. Jones, H. Witt, K. Pajter, M. Kool, M. Gilbert and K. Aldape.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

A novel fusion involving C11ORF95 and RelA was recently described in supratentorial ependymomas. We sought to further characterize the clinical relevance of this fusion. We evaluated a...

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A New Human Lung Adenocarcinoma Cell Line Harboring the EML4-ALK Fusion Gene

Hideko Isozaki, Masayuki Yasugi, Nagio Takigawa, Katsuyuki Hotta, Eiki Ichihara, Akihiko Taniguchi, Shinichi Toyooka, Shinsuke Hashida, Toshiaki Sendo, Mitsune Tanimoto and Katsuyuki Kiura.

in Japanese Journal of Clinical Oncology

October 2014; p ublished online August 2014 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 2156 words.

Objective

The echinoderm microtubule associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene was identified in patients with non-small...

BI-30CHARACTERIZATION OF L1CAM AS A CLINICAL MARKER FOR THE C11orf95-RELA FUSION IN SUPRATENTORIAL EPENDYMOMAS

Khalida Wani, Terri S. Armstrong, David T. Jones, Elizabeth Vera-Bolanos, Hendrik Witt, David Capper, Stefan M. Pfister, Richard J. Gilbertson, Mark R. Gilbert and Kenneth Aldape.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: Recently, a novel oncogenic fusion involving C11orf95 and RELA genes was described in a subset of supratentorial ependymoma causing aberrant activation of the NF-κB pathway....

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P05.04A COMBINED STRATEGY FOR THE DETECTION OF BRAF FUSIONS IN PILOCYTIC ASTROCYTOMA USING RT-PCR AND FISH

H.R. Haynes.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Pilocytic astrocytomas (WHO grade I) are the most common paediatric gliomas. The FISH test for KIAA1549-BRAF fusions is most commonly used, but this is difficult to interpret....

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OP32A COMBINED STRATEGY FOR THE DETECTION OF BRAF FUSIONS IN PILOCYTIC ASTROCYTOMA USING RT-PCR AND FISH

C. Faulkner, A. Shaw, C. Wragg, M. Greenslade, H. Haynes, H. Williams, S. Lowis, M. Williams and K.M. Kurian.

in Neuro-Oncology

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Pilocytic astrocytomas can show a wide morphological spectrum making definitive histological diagnosis challenging. The FISH test for KIAA1549-BRAF fusions is most commonly...

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PM-15C11orf95-RELA FUSION ALONE IS SUFFICIENT TO FORM HUMAN SUPRATENTORIAL EPENDYMOMA-LIKE TUMOR IN MICE

Tatsuya Ozawa, David Ellison, Richard Gilbertson and Eric Holland.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Ependymomas (EMs) are primary tumors of the central nervous system that preferentially occur in children. Recent deep molecular analyses have revealed that these tumors are divided into...

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O6.07FGFR3-TACC3 AND EGFR-SEPT14 GENE FUSIONS IN ADULT GLIOMAS

A. L. Di Stefano, M. Labussiere, V. Frattini, A. Fucci, B. Boisselier, Y. Schmitt, K. Mokhtari, A. Lasorella, A. Iavarone and M. Sanson.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Novel chromosomal rearrangements involving tyrosine-kinase receptors FGFR3 and EGFR and resulting in actionable fusion proteins with strong oncogenic activity have been recently described...

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Primary Pulmonary Synovial Sarcoma Confirmed by Molecular Detection of SYT–SSX1 Fusion Gene Transcripts: a Case Report and Review of the Literature

Tatsuya Hosono, Mitsugu Hironaka, Akira Kobayashi, Hideaki Yamasawa, Masashi Bando, Shoji Ohno, Yasunori Sohara and Yukihiko Sugiyama.

in Japanese Journal of Clinical Oncology

May 2005; p ublished online May 2005 .

Journal Article. Subjects: Medical Oncology. 3008 words.

This is a case report of a rare patient with primary pulmonary synovial sarcoma. The patient was a 58-year-old woman who presented with a well-defined giant mass in the right lower field on...

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PATH-48. FUSION TESTING IN ADULT VERSUS PEDIATRIC LOW AND HIGH GRADE BRAIN TUMORS FOR ELIGIBILITY FOR TRIALS

David Ormond, Denise Damek, Nicholas Willard, Mark Ewalt and Bette Kleinschmidt-DeMasters.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Since January 2017, our molecular laboratory has assessed 47 pediatric and 23 adult primary...

Targeting Urokinase-Type Plasminogen Activator Receptor on Human Glioblastoma Tumors With Diphtheria Toxin Fusion Protein DTAT

Daniel A. Vallera, Chunbin Li, Ni Jin, Angela Panoskaltsis-Mortari and Walter A. Hall.

in JNCI: Journal of the National Cancer Institute

April 2002; p ublished online April 2002 .

Journal Article. Subjects: Medical Oncology. 7724 words.

Background: The prognosis for patients with brain cancer is poor, and new therapies are urgently needed. Recombinant toxic proteins that specifically target tumor cells appear...

Primary Synovial Sarcoma of the Lung: a Case Report Confirmed by Molecular Detection of SYT-SSX Fusion Gene Transcripts

Hiroshi Terasaki, Toshiro Niki, Tadashi Hasegawa, Tesshi Yamada, Kenji Suzuki, Masahiko Kusumoto, Kiminori Fujimoto, Naofumi Hayabuchi, Yoshihiro Matsuno and Tadakazu Shimoda.

in Japanese Journal of Clinical Oncology

May 2001; p ublished online May 2001 .

Journal Article. Subjects: Medical Oncology. 2434 words.

We report a rare case of primary synovial sarcoma of the lung. The patient was a 49-year-old woman who presented with a well-defined oval-shaped mass in the left upper lobe on a chest...

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Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

Andrea Sartore-Bianchi, Elena Ardini, Roberta Bosotti, Alessio Amatu, Emanuele Valtorta, Alessio Somaschini, Laura Raddrizzani, Laura Palmeri, Patrizia Banfi, Erica Bonazzina, Sandra Misale, Giovanna Marrapese, Antonella Leone, Rachele Alzani, David Luo, Zachary Hornby, Jonathan Lim, Silvio Veronese, Angelo Vanzulli, Alberto Bardelli, Marcella Martignoni, Cristina Davite, Arturo Galvani, Antonella Isacchi and Salvatore Siena.

in JNCI: Journal of the National Cancer Institute

P ublished online November 2015 .

Journal Article. Subjects: Medical Oncology. 1947 words.

In metastatic colorectal cancer (CRC), actionable genetic lesions represent potential clinical opportunities. NTRK1, 2, and 3 gene rearrangements encode oncogenic fusions of the...

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The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance

Huihui Chong, Xue Yao, Zonglin Qiu, Jianping Sun, Yuanyuan Qiao, Meng Zhang, Meitian Wang, Sheng Cui and Yuxian He.

in Journal of Antimicrobial Chemotherapy

October 2014; p ublished online June 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6185 words.

Objectives

Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 are potent fusion inhibitors. We have recently demonstrated that the unique...