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A prognostic nomogram to predict overall survival in patients with platinum-sensitive recurrent ovarian cancer

C. K. Lee, R. J. Simes, C. Brown, V. Gebski, J. Pfisterer, A.-M. Swart, D. Berton-Rigaud, M. Plante, T. Skeie-Jensen, I. Vergote, C. Schauer, C. Pisano, G. Parma, K. Baumann, J. A. Ledermann, E. Pujade-Lauraine, J. Bentley, G. Kristensen, A. Belau, M. Nankivell, U. Canzler, S. J. Lord, C. Kurzeder and M. Friedlander.

in Annals of Oncology

April 2013; p ublished online October 2012 .

Journal Article. Subjects: Medical Oncology. 4092 words.

Background

Patients with platinum-sensitive recurrent ovarian cancer have variable prognosis and survival. We extend previous work on prediction of...

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Vascular permeability factors in steroid-sensitive nephrotic syndrome and focal segmental glomerulosclerosis

Paul E. C. Brenchley.

in Nephrology Dialysis Transplantation

August 2003; p ublished online August 2003 .

Journal Article. Subjects: Nephrology. 0 words.

The concept that some forms of proteinuria may be induced by the action of circulating systemic permeability factors on the glomerular capillary wall is intriguing. First proposed in the...

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Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism

Mareike Lankeit, Dietrich Friesen, John Aschoff, Claudia Dellas, Gerd Hasenfuß, Hugo Katus, Stavros Konstantinides and Evangelos Giannitsis.

in European Heart Journal

August 2010; p ublished online June 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 5711 words.

Aims

To assess the role of cardiac troponin T (cTnT) levels on admission using a new, highly sensitive assay (hsTnT) in the risk assessment of normotensive...

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Salt-sensitive blood pressure—an intermediate phenotype predisposing to diabetic nephropathy?

Krzysztof Strojek, Jerome Nicod, Paolo Ferrari, Wladyslaw Grzeszczak, Juta Gorska, Bernard Dick, Felix Frey and Eberhard Ritz.

in Nephrology Dialysis Transplantation

October 2005; p ublished online May 2005 .

Journal Article. Subjects: Nephrology. 3386 words.

Background. Family studies point to important genetic determinants of diabetic nephropathy (DN). Blood pressure (BP) is higher in offspring of patients with type 2 diabetes and...

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The history of diagnosing carotid sinus hypersensitivity: why are the current criteria too sensitive?

C.T.P. (Paul) Krediet, Steve W. Parry, David L. Jardine, David G. Benditt, Michele Brignole and Wouter Wieling.

in EP Europace

January 2011; p ublished online November 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 6677 words.

The carotid sinus syndrome and carotid sinus hypersensitivity (CSH) are closely related disorders. The first is characterized by syncope triggered by manipulation of the carotid sinus in...

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Sensitive diagnosis of cardiac allograft rejection by detection of cytokine transcription in situ

Jun-ichi Suzuki, Mitsuaki Isobe, Satoshi Yamazaki, Shiro Horie, Yoshio Okubo and Morie Sekiguchi.

in Cardiovascular Research

November 1998; p ublished online November 1998 .

Journal Article. Subjects: Cardiovascular Medicine. 3345 words.

Abstract

Objective: In situ transcription of cytokines which are important in the development of cardiac rejection has not been evaluated for...

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Fatigue is a reliable, sensitive and unique outcome measure in rheumatoid arthritis

Patricia Minnock, John Kirwan and Barry Bresnihan.

in Rheumatology

December 2009; p ublished online September 2009 .

Journal Article. Subjects: Rheumatology. 3066 words.

Objective. Fatigue is an important symptom in patients with RA. Measurement of fatigue in clinical trials and in clinical practice requires scales that are reproducible,...

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The BILAG-2004 index is sensitive to change for assessment of SLE disease activity

Chee-Seng Yee, Vernon Farewell, David A. Isenberg, Bridget Griffiths, Lee-Suan Teh, Ian N. Bruce, Yasmeen Ahmad, Anisur Rahman, Athiveeraramapandian Prabu, Mohammed Akil, Neil McHugh, Christopher Edwards, David D’Cruz, Munther A. Khamashta, Peter Maddison and Caroline Gordon.

in Rheumatology

June 2009; p ublished online April 2009 .

Journal Article. Subjects: Rheumatology. 4184 words.

Objective. To determine if the BILAG-2004 index is sensitive to change for assessment of SLE disease activity.

Methods. This was a prospective...

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amiloride-sensitive sodium channels

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 96 words.

A family of voltage-insensitive sodium-permeable ion channels that are inhibited by *amiloride (compare voltage-gated sodium channels). In epithelia they constitute the rate-limiting step...

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hormone-sensitive lipase

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 40 words.

An enzyme (EC 3.1.1.79, 1076 aa) that converts stored triglyceride into free fatty acids, the rate-limiting step in mobilizing energy from the adipocyte store. The enzyme is controlled...

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voltage-sensitive calcium channels

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 83 words.

Calcium-ion specific *voltage-gated ion channels that are subdivided into six classes on the basis of electrophysiological and pharmacological criteria. They allow calcium influx into the...

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Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats

Sangita Choudhury, Soochan Bae, Sheetal R. Kumar, Qingen Ke, Bhargavi Yalamarti, Jun H. Choi, Lorrie A. Kirshenbaum and Peter M. Kang.

in Cardiovascular Research

January 2010; p ublished online July 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4831 words.

Aims

The caspases are thought to be central mediators of the apoptotic program, but recent data indicate that apoptosis may also be mediated by...

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Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes

Vivek Garg, Jundong Jiao and Keli Hu.

in Cardiovascular Research

April 2009; p ublished online January 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 5361 words.

Aims

ATP-sensitive potassium (KATP) channels in the heart are critical regulators of cellular excitability and action potentials during ischaemia. However,...

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Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model

Philippe Cottagnoud, Cynthia M. Gerber, F. Acosta, Marianne Cottagnoud, Klaus Neftel and Martin G. Täuber.

in Journal of Antimicrobial Chemotherapy

December 2000; p ublished online December 2000 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2473 words.

Linezolid, a new oxazolidinone antibiotic, showed good penetration (38 ± 4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two iv injections (20...

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Plasma semicarbazide-sensitive amine oxidase is elevated in patients with congestive heart failure

Frans Boomsma, Dirk J van Veldhuisen, Pieter J de Kam, Arie J Man in 't Veld, Arend Mosterd, Kong I Lie and Maarten A.D.H Schalekamp.

in Cardiovascular Research

February 1997; p ublished online February 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 2921 words.

Abstract

Objective: Semicarbazide-sensitive amine oxidase (SSAO) is present in various mammalian tissues, especially in vascular smooth muscle...

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Semicarbazide-sensitive amine oxidase catalyzes endothelial cell-mediated low density lipoprotein oxidation

Markus Exner, Marcela Hermann, Roland Hofbauer, Stylianos Kapiotis, Peter Quehenberger, Wolfgang Speiser, Irmtraud Held and Bernhard M.K Gmeiner.

in Cardiovascular Research

June 2001; p ublished online June 2001 .

Journal Article. Subjects: Cardiovascular Medicine. 3331 words.

Abstract

Objective: Deamination products of semicarbazide-sensitive amine oxidases (SSAO), i.e. aldehydes, superoxide and ammonia have been...

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Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes

Masafumi Takahashi, Jun Nishihira, Masahisa Shimpo, Yuka Mizue, Shuichi Ueno, Hiroyuki Mano, Eiji Kobayashi, Uichi Ikeda and Kazuyuki Shimada.

in Cardiovascular Research

December 2001; p ublished online December 2001 .

Journal Article. Subjects: Cardiovascular Medicine. 4424 words.

Abstract

Objective: Macrophage migration inhibitory factor (MIF), which plays a pivotal role in the control of inflammatory responses, was first...

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A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells

Hai Wang, Chaoliang Long, Zhibian Duan, Cuige Shi, Guodong Jia and Yingli Zhang.

in Cardiovascular Research

February 2007; p ublished online February 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 2963 words.

Abstract

Objective: Endothelial dysfunction is an early risk factor for cardiovascular disease and hypertension. Mechanisms that participate in...

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The acid-sensitive potassium channel TASK-1 in rat cardiac muscle

Caroline Putzke, Konstantin Wemhöner, Frank B. Sachse, Susanne Rinné, Günter Schlichthörl, Xian Tao Li, Lucas Jaé, Ines Eckhardt, Erhard Wischmeyer, Hinnerk Wulf, Regina Preisig-Müller, Jürgen Daut and Niels Decher.

in Cardiovascular Research

July 2007; p ublished online July 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 5369 words.

Abstract

Objective The outward current flowing through the two-pore domain acid-sensitive potassium channel TASK-1 (I TASK) and its...

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Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes

Frank J. Raucci, Dayanjan S. Wijesinghe, Charles E. Chalfant and Clive M. Baumgarten.

in Cardiovascular Research

April 2010; p ublished online December 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4516 words.

Aims

Because ceramide accumulates in several forms of cardiovascular disease and ceramide-induced apoptosis may involve the volume-sensitive Cl current, Inull...

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