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P035 Serum markers predict outcome to ustekinumab in patients with refractory Crohn’s disease and provide insides in the mechanism of action

B Verstockt, S Vermeire, S Verstockt, B Creyns, N Ardeshir Davani, C Breynaert, G Van Assche, G Van Assche and M Ferrante.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Ustekinumab (UST), targeting the IL-12/23 shared p40 subunit, was recently approved by FDA and...

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DOP068 Crohn’s disease decision aid leads to more patients choosing combination therapy in a cluster randomised controlled trial

C A Siegel, K D Thompson, L S Siegel, T MacKenzie and M C Dubinsky.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Data support the use of early intensive therapy with a combination of an anti-tumour necrosis...

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P611 Outcome in ulcerative colitis after switch from subcutaneous anti-TNF to intravenous anti-TNF: A multicentre study

A Viola, D Pugliese, S Renna, F Furfaro, F Caprioli, R D'Inca', F Bossa, G Costantino, M Fantini, G Fiorino, A Armuzzi, A Orlando and W Fries.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

The anti-TNF therapies infliximab (IFX) and, more recently, adalimumab (ADA), and golimumab...

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P720 Is there a difference in trough levels and immunogenicity between Crohn’s disease and ulcerative colitis patients treated with infliximab?

D Perdigoto, C Macedo, F Portela, S Lopes, M Ferreira, M Ferreira, S Mendes and L Tomé.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Immunogenicity directed to infliximab (IFX) administration can lead to secondary loss of...

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DOP046 Higher serum concentrations of vedolizumab are associated with superior endoscopic outcomes in Crohn’s disease: data from the LOVE-CD trial

S Berends, M Löwenberg, F Baert, R Mathôt, E Clasquin, C Van Der Woude, F Hoentjen, P Bossuyt, D Franchimont, T Rispens, A De Vries, S Vermeire and G D'Haens.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Vedolizumab (VDZ) is an anti-α4β7 integrin registered for treatment of moderate to severe...

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P843 Upadacitinib-induced endoscopic improvement is associated with modulation of pathways involved in Crohn’s disease pathogenesis

D Aguilar, N Planell, J Panés, A Lacerda, J Butler, J W Davis and A Salas.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Upadacitinib (UPA; ABT-494) is an oral JAK1 selective inhibitor being investigated to treat...

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P749 A comparative analysis of low bioavailability steroids in inducing clinical response and remission in ulcerative colitis: Budesonide MMX as the safest option

B Scrivo, E Giuffrida, V Calvaruso and M Cappello.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

5-Aminosalicylates (5-ASA) are first-line treatment for induction of remission in mild to...

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DOP047 Infliximab exposure predicts superior endoscopic outcomes in patients with active Crohn’s disease: pharmacokinetic–pharmacodynamic analysis of TAILORIX

E Dreesen, G D'Haens, F Baert, B Pariente, Y Bouhnik, J vander Woude, J Moreau, D Laharie, S Vermeire and A Gils.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

In the TAILORIX study, “proactive” dose escalation based on infliximab (IFX) serum...

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P325 Risk factors for lymph node involvement in patients undergoing ileal pouch-anal anastomosis for ulcerative colitis complicated by colorectal cancer in the biological years

M Rottoli, F Ghignone, M Tanzanu, L Boschi, F Rizzello, P Gionchetti and G Poggioli.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Patients affected by ulcerative colitis (UC) have an increased risk of developing colorectal...

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P564 Indigo naturalis induces mucosal healing in patients with ulcerative colitis: A multicentre randomised controlled trial

M Naganuma, S Sugimoto, K Mitsuyama, T Kobayashi, N Yoshimura, H Ohi, K Matsuoka, T Hisamatsu, K Watanabe, T Abe, M Watanabe, T Hibi, Y Suzuki and T Kanai.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Indigo naturalis (IN) contains ligands for the aryl hydrocarbon receptor and promotes...

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P463 Long-term effects of anti-TNF therapy on bone metabolism

N O'Morain, G Farrell, M Hanly, S Veerappan, D McNamara, N Breslin, C O'Morain, M Healy and B Ryan.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Bone loss associated with inflammatory diseases is induced by pro-inflammatory cytokines, which...

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P049 HLA B27 transgenic rat: a new animal model of ileitis post-surgery reproducing inflammatory bowel disease

A Chau, L Schneider, C Chater, S Speca, M Djouina, C Dubuquoy, L Dubuquoy, C Neut, D Koriche, F R Pruvot, P Desreumaux, P Zerbib and B Pariente.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Ileal recurrence (IR) of Crohn’s disease (CD) after ileocaecal resection (ICR) concerns the...

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P582 Vedolizumab: Effects on liver function in an IBD and IBD/PSC cohort

J Doherty, M Buckley, G Cullen, G Horgan, H Mulcahy, G Doherty and J Sheridan.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

Primary sclerosing cholangitis (PSC) is a disease characterised by inflammation and destruction...

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P164 Into intimacy: Impact of IBD in sexual health

D Martins, F Pires, J Pinho, P Sousa, R Cardoso, R Araújo, E Cancela, A Castanheira, A Silva and P Ministro.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

IBD is likely to perturb sexual function due to its symptoms, need for pharmacological and...

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P612 Immunosuppressive co-treatment with infliximab and adalimumab is not superior to anti-TNF monotherapy to prevent treatment failure and treatment discontinuation in ulcerative colitis

S Vieujean, E Louis and C Reenaers.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

In Ulcerative colitis (UC) although some studies suggest a benefit of combination therapy of...

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P151 Characteristics of presentation and risk factors for early recurrence after strictureplasty for Crohn’s disease of the small bowel in the biological era

M Rottoli, C Vallicelli, M Melina, C A Manzo, P Gionchetti, F Rizzello, L Boschi, M Di Simone and G Poggioli.

in Journal of Crohn's and Colitis

January 2018; p ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Gastroenterology; Gastro-intestinal and Colorectal Surgery; Health, Illness, and Medicine. 0 words.

Abstract

Background

There is a lack in the literature about timing of recurrence and risk factors for early relapse...

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