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Antioxidant protection against PCB-mediated endothelial cell activation.

R Slim, M Toborek, L W Robertson and B Hennig.

in Toxicological Sciences

December 1999; p ublished online December 1999 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Certain environmental contaminants such as polyhalogenated aromatic hydrocarbons may be implicated in diseases of the vasculature by compromising normal functions of vascular endothelial...

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Fasting Augments PCB Impact on Liver Metabolism in Anadromous Arctic Char

Mathilakath M. Vijayan, Neelakanteswar Aluru, Alec G. Maule and Even H. Jørgensen.

in Toxicological Sciences

June 2006; p ublished online March 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6476 words.

Anadromous arctic char (Salvelinus alpinus) undertake short feeding migrations to seawater every summer and accumulate lipids, while the rest of the year is spent in fresh water where the...

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Ortho-Substituted PCBs Kill Cells by Altering Membrane Structure

Yuansheng Tan, Chang-Hwei Chen, David Lawrence and David O. Carpenter.

in Toxicological Sciences

July 2004; p ublished online March 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4372 words.

Our previous studies have demonstrated that ortho-substituted PCBs cause a rapid cell death in both thymocytes and cerebellar granule cell neurons, whereas coplanar congeners are without...

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Comparison of Pharmacokinetic Interactions and Physiologically Based Pharmacokinetic Modeling of PCB 153 and PCB 126 in Nonpregnant Mice, Lactating Mice, and Suckling Pups

Sun Ku Lee, Ying C. Ou and Raymond S. H. Yang.

in Toxicological Sciences

January 2002; p ublished online January 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6586 words.

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that can induce neurological defects in infants and children via placental and lactational transfer. To...

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Effects of PCB Exposure on the Toxic Impact of Organophosphorus Insecticides

Russell L. Carr, Jason R. Richardson, John A. Guarisco, Anil Kachroo, Janice E. Chambers, Terrilyn A. Couch, Godwin C. Durunna and Edward C. Meek.

in Toxicological Sciences

June 2002; p ublished online June 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9068 words.

Exposure to polychlorinated biphenyls (PCBs) can alter the metabolism of organophosphorus (OP) insecticides. Female rats were fed vanilla wafers containing either 4 mg/kg/day of Aroclor...

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Auditory Effects of Developmental Exposure to Purity-Controlled Polychlorinated Biphenyls (PCB52 and PCB180) in Rats

Hellmuth Lilienthal, Päivi Heikkinen, Patrik L. Andersson, Leo T. M. van der Ven and Matti Viluksela.

in Toxicological Sciences

July 2011; p ublished online April 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8176 words.

Polychlorinated biphenyls (PCBs) are still present in the environment, with ongoing exposure in humans, including babies nursed by their mothers. Whereas toxicity of dioxin-like PCBs is...

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4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats

Leane Lehmann, Harald L.Esch, Patricia A.Kirby, Larry W.Robertson and Gabriele Ludewig.

in Carcinogenesis

August 2006; p ublished online February 2007 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6367 words.

4-Monochlorobiphenyl (PCB3) is found in small amounts in commercial PCB mixtures, indoor and outdoor air, and in food. In contrast to highly chlorinated congeners that are more resistant to...

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The Hypothalamo-Pituitary-Thyroid (HPT) Axis: A Target of Nonpersistent ortho-Substituted PCB Congeners

Moazzam A. Khan, Carol A. Lichtensteiger, Obaid Faroon, Moiz Mumtaz, David J. Schaeffer and Larry G. Hansen.

in Toxicological Sciences

January 2002; p ublished online January 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7705 words.

Coplanar polychlorinated biphenyls (PCBs) cause adverse effects in developing and adult animals. Less is known about the effects of nonplanar ortho-substituted PCBs. We investigated the...

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Identification of markers for PCB exposure in plasma from Swedish construction workers removing old elastic sealants

H. WINGFORS, A. I. SELDÉN, C. NILSSON and P. HAGLUND.

in The Annals of Occupational Hygiene

January 2006; p ublished online January 2006 .

Journal Article. Subjects: Occupational Medicine. 4041 words.

The objective of the present study was to identify PCB-indicators of occupational exposure related to the removal of old elastic sealants. Blood samples were collected from workers involved...

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Effects of Polychlorinated Biphenyls (PCBs) on Brain Tyrosine Hydroxylase Activity and Dopamine Synthesis in Rats

Neepa Y. Choksi, Prasada Rao S. Kodavanti, Hugh A. Tilson and Raymond G. Booth.

in Toxicological Sciences

September 1997; p ublished online September 1997 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Literature reports suggest that polychlorinated biphenyls (PCBs) may alter dopaminergic neurotransmission in mammalian forebrain. In vitro, PCBs can decrease dopamine levels in PC 12 cells...

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Motor Impairment in Rats Exposed to PCBs and Methylmercury during Early Development

Cindy S. Roegge, Victor C. Wang, Brian E. Powers, Anna Y. Klintsova, Sherilyn Villareal, William T. Greenough and Susan L. Schantz.

in Toxicological Sciences

February 2004; p ublished online February 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9268 words.

Epidemiological and laboratory studies indicate that polychlorinated biphenyls (PCBs) and methyl mercury (MeHg) may have additive or interactive adverse effects on nervous system function....

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PCB 104-Induced Proinflammatory Reactions in Human Vascular Endothelial Cells: Relationship to Cancer Metastasis and Atherogenesis

Wangsun Choi, Sung Yong Eum, Yong Woo Lee, Bernhard Hennig, Larry W. Robertson and Michal Toborek.

in Toxicological Sciences

September 2003; p ublished online September 2003 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6965 words.

Polychlorinated biphenyls (PCBs) are widespread environmental contaminants that are known to induce carcinogenic and possibly atherogenic events. Recent evidence suggests that selected PCBs...

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Auditory Deficits in Rats Exposed to an Environmental PCB Mixture during Development

Brian E. Powers, John J. Widholm, Robert E. Lasky and Susan L. Schantz.

in Toxicological Sciences

February 2006; p ublished online November 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6826 words.

Previous studies have indicated that developmental exposure to polychlorinated biphenyls (PCBs) may result in hearing impairment in rats. The cochlea is the suggested site of action, based...

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PCB-Induced Inhibition of the Vesicular Monoamine Transporter Predicts Reductions in Synaptosomal Dopamine Content

Jeffrey C. Bemis and Richard F. Seegal.

in Toxicological Sciences

August 2004; p ublished online April 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4992 words.

Both Aroclor mixtures and individual non-coplanar polychlorinated biphenyl (PCB) congeners reduce dopamine (DA) concentrations in cells in culture and in the brains of developing and adult...

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Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat

Bingxuan Wang, William D. Klaren, Brian R. Wels, Donald L. Simmons, Alicia K. Olivier, Kai Wang, Larry W. Robertson and Gabriele Ludewig.

in Toxicological Sciences

March 2016; p ublished online December 2015 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8670 words.

PCB126 (3,3′,4,4′,5-pentachlorobiphenyl) is a potent aryl hydrocarbon receptor agonist and induces oxidative stress. Because liver manganese (Mn) levels decrease in response to PCB126, a Mn...

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Ortho-Substituted but Not Coplanar PCBs Rapidly Kill Cerebellar Granule Cells

Yuansheng Tan, Renji Song, David Lawrence and David O. Carpenter.

in Toxicological Sciences

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7247 words.

Several PCB congeners were assessed for their cytotoxicity on cerebellar granule cells in an attempt to compare their structure-activity relationship as potential neurotoxicants and to...

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Dietary Selenium as a Modulator of PCB 126–Induced Hepatotoxicity in Male Sprague-Dawley Rats

Ian K. Lai, Yingtao Chai, Donald Simmons, Walter H. Watson, Rommel Tan, Wanda M. Haschek, Kai Wang, Bingxuan Wang, Gabriele Ludewig and Larry W. Robertson.

in Toxicological Sciences

November 2011; p ublished online August 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7895 words.

Homeostasis of selenium (Se), a critical antioxidant incorporated into amino acids and enzymes, is disrupted by exposure to aryl hydrocarbon receptor (AhR) agonists. Here we examined the...

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Stable isotope probing reveals the dominant role of Burkholderia species in aerobic degradation of PCBs

Stefanie Tillmann, Carsten Strömpl, Kenneth N. Timmis and Wolf-Rainer Abraham.

in FEMS Microbiology Ecology

April 2005; p ublished online January 2006 .

Journal Article. 5921 words.

Abstract

The active bacteria of a biofilm community grown directly on polychlorinated biphenyl (PCB) droplets were analyzed by 16S rRNA fingerprinting,...

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Developmental PCB Exposure Increases Audiogenic Seizures and Decreases Glutamic Acid Decarboxylase in the Inferior Colliculus

Suren B. Bandara, Paul A. Eubig, Renee N. Sadowski and Susan L. Schantz.

in Toxicological Sciences

February 2016; p ublished online November 2015 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6581 words.

Previously, we observed that developmental polychlorinated biphenyl (PCB) exposure resulted in an increase in audiogenic seizures (AGSs) in rats. However, the rats were exposed to loud...

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Formulation and Characterization of an Experimental PCB Mixture Designed to Mimic Human Exposure from Contaminated Fish

Paul J. Kostyniak, Larry G. Hansen, John J. Widholm, Rich D. Fitzpatrick, James R. Olson, Jennifer L. Helferich, Kyung Ho Kim, Helen J. K. Sable, Rich F. Seegal, Isaac N. Pessah and Susan L. Schantz.

in Toxicological Sciences

December 2005; p ublished online September 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7233 words.

Each environmental exposure matrix contains a unique mixture of PCB congeners. Since several congener types have multiple and distinct biological actions, it is important to characterize...

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