Oxford Index Search Results

You are looking at 41-60 of 356 items for:

fusion x Medical Oncology x clear all

Viral receptor blockage by multivalent recombinant antibody fusion proteins: inhibiting human rhinovirus (HRV) infection with CFY196

Fang Fang and Mang Yu.

in Journal of Antimicrobial Chemotherapy

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2236 words.

Viral receptor blockage by monoclonal antibodies (mAbs) is a common strategy to inhibit viral infection; however, no drug candidate acting by this mechanism has reached the market so far....

Go to »  abstract

Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network

G. G. Malouf, P. Camparo, S. Oudard, G. Schleiermacher, C. Theodore, A. Rustine, J. Dutcher, B. Billemont, O. Rixe, E. Bompas, A. Guillot, L. Boccon-Gibod, J. Couturier, V. Molinié and B. Escudier.

in Annals of Oncology

September 2010; p ublished online February 2010 .

Journal Article. Subjects: Medical Oncology. 2534 words.

Background: Xp11 translocation renal cell carcinoma (RCC) is an RCC subtype affecting 15% of RCC patients <45 years. We analyzed the benefit of targeted therapy [vascular...

Go to »  abstract

A Case of Estrogen Receptor Positive Secretory Carcinoma in a 9-Year-old Girl With ETV6–NTRK3 Fusion Gene

Kyoko Yorozuya, Emiko Takahashi, Junko Kousaka, Yukako Mouri, Miwa Yoshida, Kimihito Fujii, Miwa Akizuki, Shogo Nakano, Takashi Fukutomi, Yasutaka Umemoto, Toyoharu Yokoi and Hiroshi Imai.

in Japanese Journal of Clinical Oncology

March 2012; p ublished online December 2011 .

Journal Article. Subjects: Medical Oncology. 1958 words.

The patient was a 9-year-old premenarcheal pediatric female, whose chief complaint was a well-circumscribed palpable right breast mass without nipple discharge. Although the patient had...

Go to »  abstract

MNGI-04. PATHWAY ANALYSIS OF RADIATION-INDUCED MENINGIOMAS REVEALS UPREGULATION OF INFLAMMATORY PATHWAYS IN TUMORS WITH NF2-FUSION

Suganth Suppiah, Sameer Agnihotri, Mamatjan Yasin, Gelareh Zadeh, Ken Aldape and Jeff Liu.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

As more pediatric cancer patients are surviving into adulthood from improved oncological...

GENE-37. PATHWAY ANALYSIS OF RADIATION-INDUCED MENINGIOMAS REVEALS THAT TUMOURS WITH NF2-FUSION HAVE UPREGULATION OF INFLAMMATORY PATHWAYS

Suganth Suppiah, Sameer Agnihotri, Jeff Liu, Mamatjan Yasin, Ken Aldape and Gelareh Zadeh.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

As more pediatric cancer patients are surviving into adulthood from improved oncological...

LGG-08. PILOCYTIC ASTROCYTOMAS, EXHIBIT DIFFERENTIAL AGE-BASED PATTERNS OF BRAFV600E AND BRAF GENE FUSIONS ACROSS DIFFERENT LOCATIONS

Mukesh Barange, Mamta Gurav, Hetakshi Kurani, Omshree Shetty, Prakash Shetty, Aliasgar Moiyadi, Ayushi Sahay, Jayant Sastri Goda, Rahul Krishnatry, Girish Chinaswamy, Tejpal Gupta, Rakesh Jalali and Sridhar Epari.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

Pilocytic astrocytomas (PCA) are characterised by BRAF fusions and V600E mutation. MATERIAL...

TBIO-12. NON-TARGETED MUTATION AND FUSION ANALYSES CAN AID IN CLASSIFICATION AND TREATMENT OF PEDIATRIC GLIOMAS

Ahmed Gilani, Jean Mulcahy Levy and Bette Kleinschmidt-DeMasters.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Many tertiary care centers currently utilize a broad panel-based approach for assessment of potentially-actionable fusions or mutations in tumors....

LGG-25. NOVEL FGFR2 FUSIONS DRIVE ONCOGENESIS VIA MAPK AND PI3K/mTOR PATHWAY ACTIVATION IN DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS

Payal Jain, Lea Surrey, Joshua Straka, Minjie Luo, Adam C Resnick, Phillip B Storm, Mariarita Santi, Marilyn Li and Angela J Waanders.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm classified by the 2016 WHO under the mixed neuronal-glial tumors....

Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity?

Thale Kristin Olsen, Ioannis Panagopoulos, Torstein R. Meling, Francesca Micci, Ludmila Gorunova, Jim Thorsen, Bernt Due-Tønnessen, David Scheie, Marius Lund-Iversen, Bård Krossnes, Cathrine Saxhaug, Sverre Heim and Petter Brandal.

in Neuro-Oncology

October 2015; p ublished online March 2015 .

Journal Article. Subjects: Medical Oncology; Neurology. 5470 words.

Background

We have previously characterized 19 ependymal tumors using Giemsa banding and high-resolution comparative genomic hybridization. The aim of this...

EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS

Kristian W Pajtler, Konstantin Okonechnikov, Mikaella Vouri, Sebastian Brabetz, David T W Jones, Andrey Korshunov, David Capper, Lukas Chavez, Stefan M Pfister, Marcel Kool and Daisuke Kawauchi.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

In a previous study we identified two molecular groups of supratentorial (ST) ependymoma in pediatric patients driven by distinct gene fusions...

Molecular cloning and functional characterization of two novel membrane fusion proteins in conferring antimicrobial resistance in Acinetobacter baumannii

Vijaya Bharathi Srinivasan, Govindan Rajamohan, Preeti Pancholi, Mario Marcon and Wondwossen A. Gebreyes.

in Journal of Antimicrobial Chemotherapy

March 2011; p ublished online January 2011 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2665 words.

Objectives

The aim of this study was to elucidate the role of two novel membrane fusion proteins (MFPs) in the susceptibility of Acinetobacter baumannii to...

Go to »  abstract

PATH-11. DESIGNING A DIAGNOSTIC FGFR3-TACC3 FUSION ASSAY USING RT-PCR FOR GLIOBLASTOMA MULTIFORME PATIENTS

Wendy de Leng, Anne Hoskam, Joyce van Kuik, Wim Spliet, Wim Van Hecke, Pierre Robe and Filip de Vos.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

The FGFR3-TACC3 fusion protein is a recurrent translocation in glioblastoma (GBM) patients and other types of solid malignancies, and is hypothesized...

EAPH-09. POTENT CLINICAL AND RADIOLOGICAL RESPONSE TO LAROTRECTINIB IN FIRST CASE OF TRK FUSION HIGH GRADE GLIOMA

David Ziegler, Maria Tsoli, Vanessa Tyrell, Richard Cohn, Loretta Lau, Michael Cox, Mark Cowley, Paul Ekert, Glenn Marshall and Michelle Haber.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Genes encoding neurotrophin receptor kinases (TRK) have recently been implicated as an oncogenic driver in multiple tumor types including congenital...

DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis

Gallen B. Triana-Baltzer, Maria Babizki, Michael C. W. Chan, Adam C. N. Wong, Laura M. Aschenbrenner, Erin R. Campbell, Qi-Xiang Li, Renee W. Y. Chan, J. S. Malik Peiris, John M. Nicholls and Fang Fang.

in Journal of Antimicrobial Chemotherapy

February 2010; p ublished online November 2009 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7410 words.

Objectives

The influenza virus (IFV) infection models commonly used to evaluate antiviral agents (e.g. MDCK cell line and mice) are limited by physiological...

Go to »  abstract

EPEN-12. NOVEL PTCH1-INPPL1 FUSION IN A PATIENT WITH EXTRANEURAL METASTATIC EPENDYMOMA - A CASE REPORT

Gurcharanjeet Kaur, Ira Dunkel, Neerav Shukla, Ahmet Zahir and Matthias Karajannis.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Extraneural metastatic spread of ependymoma is rare, and associated molecular genetic drivers...

CRAN-20. THE TEN-YEAR EVOLUTIONARY TRAJECTORY OF A HIGHLY RECURRENT PAEDIATRIC HIGH GRADE NEUROEPITHELIAL TUMOUR WITH MN1:BEND2 FUSION

Anna Burford, Alan Mackay, Sergey Popov, Maria Vinci, Diana Carvalho, Matthew Clarke, Elisa Izquierdo, Aimee Avery, Thomas S Jacques, Wendy J Ingram, Andrew S Moore, Kieran Frawley, Timothy E Hassall and Thomas Robertson.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Astroblastomas are rare brain tumours which predominate in children and young adults, and have a controversial claim as a distinct entity, with no...

EAPH-10. SUCCESSFUL TREATMENT OF A SECONDARY PEDIATRIC HIGH GRADE GLIOMA WITH A NOVEL BEND4-NTRK2 FUSION WITH ENTRECTINIB, A TRK INHIBITOR

James Felker, Bryan Philbrook, Matthew Schneiderjan, Joshua Chern, Claire Mazewski, Bree Eaton, Edna Chow-Maneval, Tobey MacDonald and Dolly Aguilera.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

A 2 month old child with a large hemispheric tumor; after subtotal resection, pathology showed pilomyxoid astrocytoma with BRAFV600E mutation by...

P08.20EGFR MUTATIONS STATUS AND EML4 ALK FUSION IN PATIENTS WITH BRAIN METASTASES FROM NON-SMALL CELL LUNG CANCER (NSCLC) AND SURVIVAL ANALYSIS: A RETROSPECTIVE STUDY

A.D. Muggeri, B. Calabrese, S. Cerrato and B.D. Diez.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Patients with EGFR mutation may have prolonged OS after diagnosis of brain metastases independent of treatment strategy. Tumor harbouring EGFR mutation with brain metastases from NSCLC is...

Go to »  abstract

IMMU-25. ENHANCED T CELLS TUMOR RECOGNITION USING DENDRITIC CELLS PULSED WITH CHIMERIC RNAs ENCODING FULL-LENGTH LAMP-1 FUSION CONSTRUCTS

Changlin Yang, Anjelika Dechkovskaia, Jeffrey Drake, Fernanda Guimaraes, Paul Kubilis, Jianping Huang and Duane Mitchell.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Human CMV antigens have been proposed as novel targets for immunotherapy in glioblastoma (GBM)....

CADD-31. CD97 PERTUBATION BY NOVEL FUSION PROTEIN DAF-FC INHIBITS GBM INVASION AND INDUCES ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY

Alan Nguyen, Michael Safaee, Ankush Chandra, Keith Wycoff and Manish Aghi.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

The poor prognosis of GBM reflects its capacity to supplement proliferative programs with...