Oxford Index Search Results

You are looking at 41-60 of 207 items for:

fusion x Neurology x clear all

LGG-57. FUNCTIONAL CHARACTERIZATION AND EFFECTIVE TARGETING OF NRF1-BRAF AND ATG7-RAF1 FUSIONS IDENTIFIED IN ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA PATIENTS WITHOUT BRAF p.V600E MUTATION

Poonam Sonawane, Patrick Diviney, Joanna Phillips, Payal Jain, Phillip Storm, Adam Resnick and Angela Waanders.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Pleomorphic xanthoastrocytoma (PXA) is a type of astrocytic glial neoplasm classified as WHO grade II and anaplastic PXA as WHO grade III. These...

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LGG-46. TRAMETINIB THERAPY IN PEDIATRIC PATIENTS WITH LOW-GRADE GLIOMAS (LGG) WITH BRAF GENE FUSION; A DISEASE-SPECIFIC COHORT IN THE FIRST PEDIATRIC TESTING OF TRAMETINIB

Eric Bouffet, Mark Kieran, Darren Hargrave, Stephen Roberts, Isabelle Aerts, Alberto Broniscer, Birgit Geoerger, Kohinoor Dasgupta, Lillian Tseng, Mark Russo, Bijoyesh Mookerjee and Christopher Moertel.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

LGG is the most prevalent childhood brain tumor. BRAF fusions drive constitutive activation of...

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ATIM-16. PHASE 1 STUDY RESULTS OF M7824 (MSB0011359C), A BIFUNCTIONAL FUSION PROTEIN TARGETING TGF- AND PD-L1, AMONG PATIENTS WITH RECURRENT GLIOBLASTOMA (rGBM)

Mustafa Khasraw, Michael Weller, David Lorente Estelles, Kathryn Kolibaba, Chee Lee, Craig Gedye, Macarena De La Fuente, David Vicente, David Reardon, Laureen Ojalvo, Christoph Helwig, Carole Gourmelon and Morris Groves.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

TGF- signaling promotes tumor immunosuppression; TGF- inhibition in the tumor microenvironment...

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PNR-39DISTINCT GENE FUSIONS SEGREGATE SUB-CLASSES OF CNS-PNETs

Joseph Norman, Jonathon Torchia, Nicolas De Jay, Daniel Picard, Patricia Rakopoulos, Dariusz Adamek, Daniel Catchpoole, Steven Clifford, Xing Fan, Jason Fangusaro, Fabien Forest, Maryam Fouladi, Amar Garjjar, Yancey Gillespie, Jordan Hansford, James Hayden, Lindsay Hoffman, Suradej Hongeng, Chris Jones, Anne Jouvet, Audrey Kaorshunov, Ching Lau, Suzanne Miller, Karin Muraszko, Ho-keung Ng, Stefan Pfister, Joanna Phillips, Scott Pomeroy, Alyssa Reddy, Hazel Rogers, Helen Toledano, Timorthy Van Meter, Yin Wang, Cheng Ying Ho, Ra Young-Shin, Michael Taylor, Diane Birks, Cynthia Hawkins, Eric Bouffet, Richard Grundy, Nada Jabado, Claudia Kleinman and Annie Huang.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 203 words.

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LG-47TYPE II RAF INHIBITORS INHIBIT BRAF MUTATIONS AND TRUNCATED FUSIONS IN PEDIATRIC LOW-GRADE GLIOMAS

Mark W. Kieran, Yu Sun, Catherine Pilarz, David Calligaris, Emily J. Chadwick, John A. Alberta, Shakti H. Ramkissoon, Lori A. Ramkissoon, Veronica Matia Garcia, Kim Wilkinson, Michael Kane, Liliana Goumnerova, Susan N. Chi, Peter Manley, Karen D. Wright, Nathalie Y. Agar, Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Geoffrey Kannan, Rosalind A. Segal, Levi A. Garraway, Nathanael S. Gray, Michael Eck, Charles D. Stiles and Sara J. Buhrlage.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 235 words.

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LG-40UNUSUAL NON-PILOCYTIC HISTOPATHOLOGICAL FEATURES OF PEDIATRIC INFRATENTORIAL GLIOMAS WITH BRAF FUSION GENE: A REPORT OF 2 CASES

Christine Haberler, Andreas Kiefer, Barbara Jauk, Christian Dorfer, Thomas Czech, Giles Vince, Manuela Badiali and Irene Slavc.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 248 words.

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LG-25PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS RESPOND DIFFERENTIALLY TO TARGETED THERAPEUTICS BASED ON DIMERIZATION PROFILES

Payal Jain, Tamara Fierst, Amanda Silva, Aesha Vakil, Harry Han, Phillip J. Storm, Angela J. Waanders and Adam Resnick.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 250 words.

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EPN-30YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE

Kristian W. Pajtler, Sebastian Brabetz, Monika Mauermann, Norman Mack, Laura Sieber, David T. W. Jones, Hendrik Witt, Huiqin Körkel-Qu, Marc Zuckermann, Jan Gronych, Andrey Korshunov, David Capper, Hai-Kun Liu, Stefan M. Pfister, Marcel Kool and Daisuke Kawauchi.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 246 words.

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EPN-13EPITHELIAL-TO-MESENCHYMAL TRANSITIONS IN CHILDHOOD EPENDYMOMAS MECHANISTICALLY LINKS ONCOGENIC C11orf95-RELA FUSION DRIVEN ACTIVATION OF SNAI1/SNAIL

Prit Benny Malgulwar, Pankaj Pathak, Bapu Koundinya Desiraju, Aruna Nambirajan, Chitra Sarkar, Vaishali Suri, Manmohan Singh and Mehar Chand Sharma.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 256 words.

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LG-50MULTIPLEX DETECTION OF PEDIATRIC LOW GRADE GLIOMA SIGNATURE FUSION AND DUPLICATION TRANSCRIPTS USING THE NANOSTRING NCOUNTER SYSTEM

Scott Ryall, Anthony Arnoldo, Rahul Krishnatry, Kangzi Khor, Matthew Mistry, Uri Tabori and Cynthia Hawkins.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 250 words.

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TR-06COMBINATORIAL PATHWAY TARGETING APPROACHES FOR BRAF-FUSIONS ASSOCIATED WITH PEDIATRIC LOW-GRADE GLIOMAS

Angela Waanders, Amanda Silva, Shih-Shan Chen, Harry Han, Yuankun Zhu, Katie Boucher, Payal Jain, Tamara Fierst, Namrata Choudhari, Sabine Mueller, Daphne Haas-Kogan, Phillip Storm and Adam Resnick.

in Neuro-Oncology

June 2015; p ublished online April 2015 .

Journal Article. Subjects: Medical Oncology; Neurology. 280 words.

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GE-03HIGH RATE OF CONCURRENT BRAF-KIAA1549 GENE FUSION AND 1p DELETION IN DISSEMINATED OLIGODENDROGLIAL-LIKE LEPTOMENINGEAL TUMORS

Matthew J. Schniederjan, Fausto J. Rodriguez, Theo Nicolaides, Tarik Tihan, Peter C. Burger and Arie Perry.

in Neuro-Oncology

June 2015; p ublished online April 2015 .

Journal Article. Subjects: Medical Oncology; Neurology. 271 words.

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HG-09INFANTILE GLIOBLASTOMA WITH SARCOMATOUS HISTOLOGY DRIVEN BY ETV6:NTRK3 FUSIONS ARE SENSITIVE TO TRK INHIBITION BY PHA-848125

Diana Carvalho, Katy Taylor, Anna Burford, Ilona Nowak, Alan Mackay, Mara Vinci, Lynn Bjerke, Valeria Molinari, Meera Nandhabalan, Wendy Ingram, Alexa Jury, Rachael Natrajan, David Jones, Stefan Pfister, Ludmila Shats, Andrew Moore, Thomas Jacques, Sergey Popov and Chris Jones.

in Neuro-Oncology

June 2015; p ublished online April 2015 .

Journal Article. Subjects: Medical Oncology; Neurology. 295 words.

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EPN-03C11orf95-RELA FUSION POSITIVE PEDIATRIC SUPRATENTORIAL EPENDYMOMAS ARE AN AGGRESSIVE SUBSET WITH INCREASED EXPRESSION OF STEM CELL MARKER NESTIN AND VASCULAR ENDOTHELIAL DERIVED GROWTH FACTOR

Aruna Nambirajan, Prit Benny Malgulwar, Pankaj Pathak, Mohammed Faruq, Madhu Rajeshwari, Rakesh Kumar Gupta, Vaishali Suri, Chitra Sarkar, Manmohan Singh and Mehar Chand Sharma.

in Neuro-Oncology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 256 words.

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GE-39VALIDATION OF GLIOMA SPHERE-FORMING CELLS AS MODELS OF GLIOBLASTOMA AND IDENTIFICATION OF NOVEL DRIVERS OF TUMORIGENESIS THROUGH COMPREHENSIVE GENOMIC CHARACTERIZATION

Qianghu Wang, Ravesanker Ezhilarasan, Siyuan Zheng, Joy Gumin, Tim Heffernan, Giulio Draetta, Frederick Lang, Roeland Verhaak and Erik Sulman.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Glioma sphere-forming cells (GSCs) play important roles in tumor maintenance and chemotherapy and radiation resistance, and thus serve as important models for the development of novel...

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GE-07THE GENOMIC LANDSCAPE OF DIVERSE BRAIN TUMORS REVEALS KNOWN AND NOVEL ONCOGENIC ALTERATIONS FREQUENTLY ASSOCIATED WITH SENSITIVITY TO TARGETED INHIBITORS

Juliann Chmielecki, Garrett Frampton, Deborah Morosini, Siraj Ali, Doron Lipson, Roman Yelensky, Jeffrey Ross, Vincent Miller and Philip Stephens.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: Brain tumors are complex cancers that range in behavior from aggressive to indolent. While some oncogenic alterations have been identified in these tumors, the efficacy of...

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P07.05THE ROLE OF SURGERY IN PALLIATIVE TREATMENT OF METASTASES INVOLVING THE CERVICAL SPINE. OUR EXPERIENCE AND REVIEW OF THE LITERATURE

F. Romeo, S. Toscano, M. Blagia, M. Fina, P. Proto, M. Casiello, P. Colella, G. Cozza and A. D'Agostino.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Spinal column is the most common site of skeletal metastases. Cervical spine involvement may occur in 10% of cases. In cervical spine metastases the surgery may have an...

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GE-19GENOMICS GUIDED THERAPEUTIC APPROACH FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME (GBM) USING NEXT GENERATION SEQUENCING (NGS) TECHNOLOGIES

Daniel Ma, Jann Sarkaria, Sen Peng, Sara Byron, David Craig, John Carpten, Michael Berens, Brian O'Neill, Mark Schroeder and Nhan Tran.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: The genomic heterogeneity of glioblastoma likely underlies the low response rates (8-24%) for targeted agents among unselected populations. We tested whether NGS would be useful...

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OP17MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS

Jennie N. Jeyapalan, Tania A. Jones, Ruth G. Tatevossian, Ibrahim Qaddoumi, David W. Ellison and Denise Sheer.

in Neuro-Oncology

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: MicroRNAs regulate gene expression by targeting mRNAs for translational repression or degradation at the post-transcriptional level. In paediatric low-grade gliomas a few key...

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Significance of interleukin-13 receptor alpha 2–targeted glioblastoma therapy

Bart Thaci, Christine E. Brown, Emanuela Binello, Katherine Werbaneth, Prakash Sampath and Sadhak Sengupta.

in Neuro-Oncology

October 2014; p ublished online April 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 6299 words.

Glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors despite surgical and therapeutic advancements. Targeted therapies of neoplastic diseases, including GBM,...

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