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Endothelin signalling regulates volume-sensitive Cl current via NADPH oxidase and mitochondrial reactive oxygen species

Wu Deng, Lia Baki and Clive M. Baumgarten.

in Cardiovascular Research

October 2010; p ublished online May 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 4844 words.

Aims

We assessed regulation of volume-sensitive Cl current (I Cl,swell) by endothelin-1 (ET-1) and characterized the signalling pathway...

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Individualized outcome measures of daily activities are sensitive tools for evaluating hand surgery in rheumatic diseases

Pia Malcus Johnsson, Gunnel Sandqvist, Anna-Lena Sturesson, Anders Gulfe, Philippe Kopylov, Magnus Tägil and Pierre Geborek.

in Rheumatology

December 2012; p ublished online September 2012 .

Journal Article. Subjects: Rheumatology. 2650 words.

Objectives. To explore the ability of six outcome measures to capture clinically important changes in patients with rheumatic diseases undergoing hand surgery and to study...

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Highly sensitive ELISA for determining serum keratan sulphate levels in the diagnosis of OA

Shigeyuki Wakitani, Takahiro Okabe, Amu Kawaguchi, Masashi Nawata and Yusuke Hashimoto.

in Rheumatology

January 2010; p ublished online November 2009 .

Journal Article. Subjects: Rheumatology. 3496 words.

Objective. There have been a large number of reports on alterations in the serum level of keratan sulphate (KS), a potential marker of articular cartilage degeneration in...

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Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres

Peter E. Light, Jonathan M. Cordeiro and Robert J. French.

in Cardiovascular Research

November 1999; p ublished online November 1999 .

Journal Article. Subjects: Cardiovascular Medicine. 8322 words.

Abstract

Objective: Our goal was to identify the ATP-sensitive potassium (KATP) channels in cardiac Purkinje cells and to document the...

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Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects

Ana M. Ponce, Benjamin L. Viglianti, Daohai Yu, Pavel S. Yarmolenko, Charles R. Michelich, Janet Woo, Marcel B. Bally and Mark W. Dewhirst.

in JNCI: Journal of the National Cancer Institute

January 2007; p ublished online January 2007 .

Journal Article. Subjects: Medical Oncology. 8857 words.

Background

In preclinical studies, lysolipid-based temperature-sensitive liposomes (LTSLs) containing chemotherapy drugs administered in...

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Comparative Efficacy of Antihypertensive Agents in Salt-Sensitive Hypertensive Patients: A Network Meta-Analysis

Han Qi, Zheng Liu, Han Cao, Wei-Ping Sun, Wen-Juan Peng, Bin Liu, Sheng-Jie Dong, Yu-Tao Xiang and Ling Zhang.

in American Journal of Hypertension

June 2018; p ublished online February 2018 .

Journal Article. Subjects: Cardiovascular Medicine; Biological Sciences. 6577 words.

Abstract

BACKGROUND

Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential...

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METB-02. A SENSITIVE METABOLIC SIGNATURE TO PREDICT IMMUNE RESPONSE AFTER IMMUNOTHERAPY FOR BRAIN TUMORS

Farhad Dastmalchi, Aida Karachi, Ram Khattri, Matthew E Merritt, Duane Mitchell and Maryam Rahman.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

We recently demonstrated that migration of dendritic cells (DCs) to the draining lymph nodes...

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Rapid and Sensitive Quantitative Analysis of Alkyl Phosphates in Urine after Organophosphate Poisoning

N. Kupfermann, A. Schmoldt and H. Steinhart.

in Journal of Analytical Toxicology

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Organophosphate compounds are widely used as pesticides. After ingestion by humans, organophosphates decompose into alkyl phosphates. Decomposition continues postmortem. We developed a...

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A One-Step and Sensitive GC-MS Assay for Meprobamate Determination in Emergency Situations

Sandrine Daval, Damien Richard, Bertrand Souweine, Alain Eschalier and François Coudore.

in Journal of Analytical Toxicology

June 2006; p ublished online June 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

A rapid, sensitive, and ready-to-use gas chromatography-mass spectrometry method for meprobamate assay using carisoprodol as internal standard is described. The method involves extracting a...

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Fitness Parameters and DNA Effects Are Sensitive Indicators of Copper-Induced Toxicity in Daphnia magna

Franck A. Atienzar, Victoria V. Cheung, Awadhesh N. Jha and Michael H. Depledge.

in Toxicological Sciences

February 2001; p ublished online February 2001 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7098 words.

This study compared the effects occurring at molecular and population levels in Daphnia magna exposed to copper concentrations in the range of 15–120 μg/l. The qualitative and quantitative...

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A sensitive phenotypic assay for the determination of human immunodeficiency virus type 1 tropism

Nuria González, Mayte Pérez-Olmeda, Elena Mateos, Almudena Cascajero, Amparo Alvarez, Sanne Spijkers, Javier García-Pérez, Sonsoles Sánchez-Palomino, Ezequiel Ruiz-Mateos, Manuel Leal and José Alcami.

in Journal of Antimicrobial Chemotherapy

December 2010; p ublished online October 2010 .

Journal Article. Subjects: Medical Oncology; Critical Care. 4781 words.

Objectives

To develop a sensitive phenotypic assay based on recombinant viruses (RVs) for characterizing HIV-1 tropism.

Methodsnull...

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Cadmium-Induced Differential Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation

Joshua F. Robinson, Xiaozhong Yu, Sungwoo Hong, William C. Griffith, Richard Beyer, Euvin Kim and Elaine M. Faustman.

in Toxicological Sciences

January 2009; p ublished online October 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8047 words.

Common inbred mouse strains, such as the C57BL/6 (C57) and the SWV, display differences in sensitivity to environmental teratogens during gestation. For example, the C57 is more sensitive...

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Effects of In Utero and Lactational TCDD Exposure on Bone Development in Differentially Sensitive Rat Lines

Hanna M. Miettinen, Pasi Pulkkinen, Timo Jämsä, Jaana Koistinen, Ulla Simanainen, Jouko Tuomisto, Juha Tuukkanen and Matti Viluksela.

in Toxicological Sciences

June 2005; p ublished online March 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7597 words.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a notorious model compound of highly toxic environmental pollutants, polychlorinated dibenzo-p-dioxins (PCDDs). Their toxic effects are...

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Brain Fos Induction Is a Sensitive Biomarker for the Lowest Observed Neuroexcitatory Effects of Domoic Acid

YONG G. PENG and JOHN S. RAMSDELL.

in Toxicological Sciences

June 1996; p ublished online June 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Domoic acid induces Fos in several brain regions controlling memory processing and gastrointestinal functions. In the present study, we determined serum levels of domoic acid that caused...

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Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies

Denys Fontaine, Fabien Almairac, Serena Santucci, Charlotte Fernandez, Radhouane Dallel, Johan Pallud and Michel Lanteri-Minet.

in Brain

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System; Pain Medicine. 3753 words.

Abstract

Our knowledge on intracranial pain-sensitive structures in humans comes essentially from observations during neurosurgical procedures performed in...

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Flow-sensitive four-dimensional magnetic resonance imaging: flow patterns in ascending aortic aneurysms

Ernst Weigang, Fabian A. Kari, Friedhelm Beyersdorf, Maximilian Luehr, Christian D. Etz, Alex Frydrychowicz, Andreas Harloff and Michael Markl.

in European Journal of Cardio-Thoracic Surgery

July 2008; p ublished online July 2008 .

Journal Article. Subjects: Cardiovascular Medicine; Cardiothoracic Surgery. 4114 words.

Objective: Pathological aortic flow patterns differ significantly from haemodynamics within the healthy aorta. Development and impact of pathological flow is largely unknown...

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A Rapid and Sensitive ESI-MS Screening Procedure for Ketamine and Norketamine in Urine Samples*

Ahai C. Lua and Huei R. Lin.

in Journal of Analytical Toxicology

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Traditionally, ketamine was analyzed with gas chromatography (GC) equipped with nitrogen-phosphorus detection, flame-ionization detection, and mass selective detection (MSD) or with liquid...

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Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice

Jian Ying, Deborah Stuart, Elaine Hillas, Barbu R. Gociman, Nirupama Ramkumar, Jean-Marc Lalouel and Donald E. Kohan.

in American Journal of Hypertension

June 2012; p ublished online June 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 4201 words.

Background

The role of proximal tubule (PT) angiotensinogen (AGT) in modulating blood pressure has previously been examined using mice expressing PT human...

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A Rapid and Sensitive Technique for Assessing Exposure VX via GC-MS-MS Analysis

Jeffrey M. McGuire, Christopher E. Byers, Stanley W. Hulet, Edward M. Jakubowski and Sandra A. Thomson.

in Journal of Analytical Toxicology

January 2008; p ublished online January 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

A rapid and sensitive method for the determination of the chemical warfare agent VX in plasma taken from Göttingen minipigs® has been developed using isotope-dilution gas...

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Investigation of Drug-Induced Mitochondrial Toxicity Using Fluorescence-Based Oxygen-Sensitive Probes

James Hynes, Lisa D. Marroquin, Vladimir I. Ogurtsov, Katerina N. Christiansen, Gregory J. Stevens, Dmitri B. Papkovsky and Yvonne Will.

in Toxicological Sciences

July 2006; p ublished online April 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8970 words.

Mitochondrial dysfunction is a common mechanism of drug-induced toxicity. Early identification of new chemical entities (NCEs) that perturb mitochondrial function is of significant...

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