Oxford Index Search Results

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steric hindrance x clear all

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

Jiafeng Gu, Haihui Lu, Albert G. Tsai, Klaus Schwarz and Michael R. Lieber.

in Nucleic Acids Research

September 2007; p ublished online August 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4064 words.

The double-strand DNA break repair pathway, non-homologous DNA end joining (NHEJ), is distinctive for the flexibility of its nuclease, polymerase and ligase activities. Here we find that...

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Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids

Ki-Hyun Kim, Peter E. Nielsen and Peter M. Glazer.

in Nucleic Acids Research

December 2007; p ublished online October 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5855 words.

Sequence-specific DNA-binding molecules such as triple helix-forming oligonucleotides (TFOs) provide a means for inducing site-specific mutagenesis and recombination at chromosomal sites in...

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The positive and negative regulation of Tn10 transposition by IHF is mediated by structurally asymmetric transposon arms

Sven Sewitz, Paul Crellin and Ronald Chalmers.

in Nucleic Acids Research

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7165 words.

The Tn10 transpososome has symmetrical components on either side: there are two transposon ends each of which has binding sites for a monomer of transposase and an IHF heterodimer. The DNA...

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Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA

Uffe Koppelhus, Vladimir Zachar, Peter E. Nielsen, Xiangdon Liu, Jesper Eugen-Olsen and Peter Ebbesen.

in Nucleic Acids Research

June 1997; p ublished online June 1997 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4513 words.

We have tested the inhibitory potential of peptide nucleic acid (PNA) on in vitro reverse transcription of the HIV-1 gag gene. PNA was designed to target different regions of the HIV-1 gag...

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Chiral and steric effects in the efficient binding of α-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA

Alain Laurent, Magali Naval, Françoise Debart, Jean-Jacques Vasseur and Bernard Rayner.

in Nucleic Acids Research

November 1999; p ublished online November 1999 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4771 words.

We report hybridization properties of new phosphate-modified α-oligonucleoside analogs with non-ionic or cationic internucleotide linkages such as methoxy-ethylphosphoramidate (PNHME),...

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Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe

Fang Wei, Jianghua Wang, Wei Liao, Bernhard G. Zimmermann, David T. Wong and Chih-Ming Ho.

in Nucleic Acids Research

June 2008; p ublished online May 2008 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4015 words.

We developed a technique for electrochemical detection of salivary mRNA employing a hairpin probe (HP). Steric hindrance (SH) suppresses unspecific signal and generates a signal-on...

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Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acids

Pallavi Lonkar, Ki-Hyun Kim, Jean Y. Kuan, Joanna Y. Chin, Faye A. Rogers, Melissa P. Knauert, Ryszard Kole, Peter E. Nielsen and Peter M. Glazer.

in Nucleic Acids Research

June 2009; p ublished online April 2009 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6256 words.

β-Thalassemia is a genetic disorder caused by mutations in the β-globin gene. Triplex-forming oligonucleotides and triplex-forming peptide nucleic acids (PNAs) have been shown to stimulate...

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Bacteriophage T4 endonuclease II, a promiscuous GIY-YIG nuclease, binds as a tetramer to two DNA substrates

Pernilla Lagerbäck, Evalena Andersson, Christer Malmberg and Karin Carlson.

in Nucleic Acids Research

October 2009; p ublished online August 2009 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7714 words.

The oligomerization state and mode of binding to DNA of the GIY-YIG endonuclease II (EndoII) from bacteriophage T4 was studied using gel filtration and electrophoretic mobility shift assays...

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Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G·G·X·O tetrad

Vee Vee Cheong, Brahim Heddi, Christopher Jacques Lech and Anh Tuân Phan.

in Nucleic Acids Research

December 2015; p ublished online September 2015 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5902 words.

G-quadruplexes are four-stranded structures built from stacked G-tetrads (G·G·G·G), which are planar cyclical assemblies of four guanine bases interacting through Hoogsteen hydrogen bonds....

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Stable Oil Bodies Sheltered by a Unique Oleosin in Lily Pollen

Pei-Luen Jiang, Co-Shing Wang, Chia-Mei Hsu, Guang-Yuh Jauh and Jason T. C. Tzen.

in Plant and Cell Physiology

June 2007; p ublished online June 2007 .

Journal Article. Subjects: Biochemistry; Molecular and Cell Biology; Plant Sciences and Forestry. 4922 words.

Stable oil bodies were purified from mature lily (Lilium longiflorum Thunb.) pollen. The integrity of pollen oil bodies was maintained via electronegative repulsion and steric hindrance...

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Analysis of the Three Essential Constituents of Oil Bodies in Developing Sesame Seeds

Chi-Chung Peng and Jason T.C. Tzen.

in Plant and Cell Physiology

January 1998; p ublished online January 1998 .

Journal Article. Subjects: Biochemistry; Molecular and Cell Biology; Plant Sciences and Forestry. 0 words.

Oil bodies of plant seeds contain a matrix of triacylglycerols surrounded by a monolayer of phospholipids embedded with alkaline proteins termed oleosins. Triacylglycerols and two oleosin...

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Classification of the Single Oleosin Isoform and Characterization of Seed Oil Bodies in Gymnosperms

Lawrence S.H. Wu, Grace H.H. Hong, Roger F. Hou and Jason T.C. Tzen.

in Plant and Cell Physiology

January 1999; p ublished online January 1999 .

Journal Article. Subjects: Biochemistry; Molecular and Cell Biology; Plant Sciences and Forestry. 0 words.

Oleosins are hydrophobic proteins abundantly present in the oil bodies of plant seeds. Two immunologically distinct oleosins are present in seed oil bodies of diverse angiosperms, and...

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Using a residue clash map to functionally characterize protein recombination hybrids

Manish C. Saraf and Costas D. Maranas.

in Protein Engineering, Design and Selection

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Proteins. 5918 words.

In this article, we introduce a rapid, protein sequence database‐driven approach to characterize all contacting residue pairs present in protein hybrids for inconsistency with protein...

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Multimer formation as a consequence of separate homodimerization domains: the human c-Jun leucine zipper is a transplantable dimerization module

L.G. Riley, G.B. Ralston and A.S. Weiss.

in Protein Engineering, Design and Selection

February 1996 .

Journal Article. Subjects: Proteins. 0 words.

Human c-Jun and c-Fos leucine zipper domains were examined for their ability to serve as autonomous dimerization domains as part of a heterologous protein construct. Schistosoma japonicum g...

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Construction of novel subtilisin E with high specificity, activity and productivity through multiple amino acid substitutions.

H Takagi, I Ohtsu and S Nakamori.

in Protein Engineering, Design and Selection

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Proteins. 0 words.

Through three cumulative amino acid substitutions, we constructed novel mutant subtilisins E of Bacillus subtilis, all with high specificity, activity and productivity. The substitution of...

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Relocation of Cys374 of Actin Induced by Labeling with Fluorescent Dyes

Takuo Yasunaga and Takeyuki Wakabayashi.

in The Journal of Biochemistry

February 2001; p ublished online February 2001 .

Journal Article. Subjects: Biochemistry. 0 words.

Cys374 is an important landmark of actin, because its sulfhydryl group is reactive and can be labeled with various reagents. The atomic coordinates of actin Cys374 have been determined by...

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A New Method for Seed Oil Body Purification and Examination of Oil Body Integrity Following Germination

Jason T.C. Tzen, Chi-Chung Peng, Dor-Jih Cheng, Emily C.F. Chen and Joyce M.H. Chiu.

in The Journal of Biochemistry

April 1997; p ublished online April 1997 .

Journal Article. Subjects: Biochemistry. 0 words.

Plant seeds store triacylglycerols as energy sources for germination and postgerminative growth of seedlings. The triacylglycerols are preserved in small, discrete, intracellular organelles...

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N-Glycans Protect Proteins from Protease Digestion through Their Binding Affinities for Aromatic Amino Acid Residues

Tomoko Nishiyama, Naoya Kimura, Yuki Jitsuhara, Makoto Uchida, Fumiko Ochi and Haruki Yamaguchi.

in The Journal of Biochemistry

March 2000; p ublished online March 2000 .

Journal Article. Subjects: Biochemistry. 0 words.

It was previously revealed [Yamaguchi, H., Nishiyama, T., and Uchida, M. (1999) J. Bio-chem. 126, 261-265] that N-glycans of both the high-mannose and complex types have binding affinity...

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Effect of Geometric Isomerism in Dinuclear Platinum Antitumour Complexes on the Rate of Formation and Structure of Intrastrand Adducts with Oligonucleotides

Kirste J. Mellish, Yun Qu, Neel Scarsdale and Nicholas Farrell.

in Nucleic Acids Research

March 1997; p ublished online March 1997 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 3858 words.

The dinuclear platinum complexes [{trans-PtCl (NH3)2}2µ-{HNH2(CH2) n NH2}](NO3)2 [1,1/t,t (n = 4,6)] and [{cis-PtCl(NH3)2}2µ-{NH2(CH2) nnull...

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Cefuroxime resistance in non-β-lactamase Haemophilus influenzae is linked to mutations in ftsI

K. Straker, M. Wootton, A. M. Simm, P. M. Bennett, A. P. MacGowan and T. R. Walsh.

in Journal of Antimicrobial Chemotherapy

March 2003; p ublished online March 2003 .

Journal Article. Subjects: Medical Oncology; Critical Care. 4902 words.

The penicillin binding protein (PBP) genes dacA, dacB and ftsI from 14 cefuroxime-resistant (CXMR) isolates and three clinical isolates with low CXM MIC for non-β-lactamase-producing Haemoph...

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