Oxford Index Search Results

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steric hindrance x clear all

Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

Hong Mu, Konstantin Kropachev, Lihua Wang, Lu Zhang, Alexander Kolbanovskiy, Marina Kolbanovskiy, Nicholas E. Geacintov and Suse Broyde.

in Nucleic Acids Research

October 2012; p ublished online August 2012 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9943 words.

Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2′-deoxyguanosin-8-yl)-2-aminoflu...

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A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin

Geun-Bae Kim, Zhirui Wang, Yuan Yi Liu, Scott Stavrou, Askale Mathias, K.Jeanine Goodwin, Judith M. Thomas and David M. Neville.

in Protein Engineering, Design and Selection

September 2007; p ublished online August 2007 .

Journal Article. Subjects: Proteins. 4776 words.

T-cell depleting anti-CD3 immunotoxins have utility in non-human primate models of transplantation tolerance and autoimmune disease therapy. We recently reported that an affinity matured...

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Improved binding of a bivalent single-chain immunotoxin results in increased efficacy for in vivo T-cell depletion

Jerry Thompson, Scott Stavrou, Marla Weetall, J.Mark Hexham, Mary Ellen Digan, Zhuri Wang, Jung Hee Woo, Yongjun Yu, Askale Mathias, Yuan Yi Liu, Shenglin Ma, Irina Gordienko, Philip Lake and David M. Neville.

in Protein Engineering, Design and Selection

December 2001; p ublished online December 2001 .

Journal Article. Subjects: Proteins. 5696 words.

Anti-CD3 immunotoxins exhibit considerable promise for the induction of transplantation tolerance in pre-clinical large animal models. Recently an anti-human anti-CD3ε single-chain...

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Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody

Vasily V. Ivanenkov, Patrick A. Crawford, Aimi Toyama, Jean Sévigny and Terence L. Kirley.

in Protein Engineering, Design and Selection

July 2010; p ublished online May 2010 .

Journal Article. Subjects: Proteins. 7264 words.

We adapted the method of epitope mapping by site-directed masking, which was described for purified soluble antigens [Paus,D. and Winter,G. (2006) Proc. Natl Acad. Sci. USA, 103,...

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Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing

Silke Metz, Christian Panke, Alexander K. Haas, Jürgen Schanzer, Wilma Lau, Rebecca Croasdale, Eike Hoffmann, Britta Schneider, Johannes Auer, Christian Gassner, Birgit Bossenmaier, Pablo Umana, Claudio Sustmann and Ulrich Brinkmann.

in Protein Engineering, Design and Selection

October 2012; p ublished online September 2012 .

Journal Article. Subjects: Proteins. 7008 words.

We have designed bispecific antibodies that bind one target (anti-Her3) in a bivalent IgG-like manner and contain one additional binding entity (anti-cMet) composed of one VH and one VL dom...

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Azide- and Cyanide-Binding to the Escherichia coli bd-Type Ubiquinol Oxidase Studied by Visible Absorption, EPR and FTIR Spectroscopies

Motonari Tsubaki, Tatsushi Mogi and Hiroshi Hori.

in The Journal of Biochemistry

September 1999; p ublished online September 1999 .

Journal Article. Subjects: Biochemistry. 0 words.

Cytochrome bd-type ubiquinol oxidase contains two hemes b (b 356 and b 596) and one heme d as the redox metal centers. To clarify the structure of the reaction...

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Interactions of the Organophosphates Paraoxon and Methyl Paraoxon with Mouse Brain Acetylcholinesterase

Stacey A. Kardos and Lester G. Sultatos.

in Toxicological Sciences

November 2000; p ublished online November 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5618 words.

The mechanism of acute toxicity of the organophosphorus insecticides has been known for many years to be inhibition of the critical enzyme acetylcholinesterase (EC 3.1.1.7), with the...

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The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo

Sang W Hyun, Anguo Liu, Zhenguo Liu, Alan S Cross, Avelino C Verceles, Sadagopan Magesh, Yadagiri Kommagalla, Chandrababunaidu Kona, Hiromune Ando, Irina G Luzina, Sergei P Atamas, Kurt H Piepenbrink, Eric J Sundberg, Wei Guang, Hideharu Ishida, Erik P Lillehoj and Simeon E Goldblum.

in Glycobiology

August 2016; p ublished online September 2016 .

Journal Article. Subjects: Carbohydrates. 12049 words.

Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether...

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Interaction of the Escherichia Coli fdhF mRNA Hairpin Promoting Selenocysteine Incorporation with the Ribosome

Alexander Hüttenhofer, Johann Heider and August Böck.

in Nucleic Acids Research

October 1996; p ublished online October 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4535 words.

The codon UGA located 5′ adjacent to an mRNA hairpin within fdhF mRNA promotes the incorporation of the amino acid selenocysteine into formate dehydrogenase H of Escherichia coli. The loop...

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Molecular modeling of single polypeptide chain of calcium-binding protein p26olf from dimeric S100B(ββ)

Takanori Tanaka, Naofumi Miwa, Satoru Kawamura, Hitoshi Sohma, Katsutoshi Nitta and Norio Matsushima.

in Protein Engineering, Design and Selection

May 1999; p ublished online May 1999 .

Journal Article. Subjects: Proteins. 7363 words.

P26olf from olfactory tissue of frog, which may be involved in olfactory transduction or adaptation, is a Ca2+-binding protein with 217 amino acids. The p26olf molecule contains two...

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Interaction of Pu and Am with Bone Mineral In Vitro

R.A. Guilmette, P.S. Lindhorst and L.L. Hanlon.

in Radiation Protection Dosimetry

October 1998; p ublished online October 1998 .

Journal Article. Subjects: Nuclear Chemistry, Photochemistry, and Radiation. 0 words.

Soluble forms of actinides such as Pu or Am that reach the blood deposit in significant quantity on bone surfaces and remain attached in the absence of bone remodelling. Removal of Pu or Am...

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Deciphering the Molecular Basis of the Broad Substrate Specificity of α-Glucosidase from Bacillus sp. SAM1606

Akio Noguchi, Masayasu Yano, Yasuhiro Ohshima, Hisashi Hemmi, Misa Inohara-Ochiai, Maki Okada, Kyong-Son Min, Toru Nakayama and Tokuzo Nishino.

in The Journal of Biochemistry

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Biochemistry. 5754 words.

The α-glucosidase of Bacillus sp. strain SAM1606 is a member of glycosyl hydrolase family 13, and shows an extraordinarily broad substrate specificity and is one of very few α-glucosidases...

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De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy

Anna Fassio, Alessandro Esposito, Mitsuhiro Kato, Hirotomo Saitsu, Davide Mei, Carla Marini, Valerio Conti, Mitsuko Nakashima, Nobuhiko Okamoto, Akgun Olmez Turker, Burcu Albuz, C Nur Semerci Gündüz, Keiko Yanagihara, Elisa Belmonte, Luca Maragliano, Keri Ramsey, Chris Balak, Ashley Siniard, Vinodh Narayanan, Chihiro Ohba, Masaaki Shiina, Kazuhiro Ogata, Naomichi Matsumoto, Fabio Benfenati and Renzo Guerrini.

in Brain

June 2018; p ublished online April 2018 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cellular Systems. 8919 words.

Abstract

V-type proton (H+) ATPase (v-ATPase) is a multi-subunit proton pump that regulates pH homeostasis in all eukaryotic cells; in neurons, v-ATPase plays...

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