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bay

Overview page. Subjects: Architecture.

[Ge]

Structural division in the length of a building or roof. The unit within a building between a pair of piers or buttresses; the division of a roof marked by its main trusses.

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BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts

Thomas Krieg, Yanping Liu, Thomas Rütz, Carmen Methner, Xi-Ming Yang, Turhan Dost, Stephan B. Felix, Johannes-Peter Stasch, Michael V. Cohen and James M. Downey.

in European Heart Journal

July 2009; p ublished online April 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4647 words.

Aims

BAY 58-2667 (BAY-58) directly activates soluble guanylyl cyclase without tolerance in a nitric oxide (NO)-independent manner, and its haemodynamic...

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Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease

Bertram Pitt, Gerasimos Filippatos, Mihai Gheorghiade, Lars Kober, Henry Krum, Piotr Ponikowski, Christina Nowack, Peter Kolkhof, So-Young Kim and Faiez Zannad.

in European Journal of Heart Failure

June 2012; p ublished online May 2012 .

Journal Article. Subjects: Cardiovascular Medicine. 5191 words.

Aims

BAY 94-8862 is a novel, non-steroidal, mineralocorticoid receptor antagonist with greater selectivity than spironolactone and stronger mineralocorticoid...

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Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial

Bertram Pitt, Lars Kober, Piotr Ponikowski, Mihai Gheorghiade, Gerasimos Filippatos, Henry Krum, Christina Nowack, Peter Kolkhof, So-Young Kim and Faiez Zannad.

in European Heart Journal

August 2013; p ublished online May 2013 .

Journal Article. Subjects: Cardiovascular Medicine. 5523 words.

Aims

Mineralocorticoid receptor antagonists (MRAs) improve outcomes in patients with heart failure and reduced left ventricular ejection fraction (HFrEF),...

Go to »  full text: open access   » abstract

P319Bay 60-2770 attenuates doxorubicin-induced cardiotoxicity by preventing mitochondrial membrane potential loss

K H Lee, X X Zhao, H Cho, S R Lee, J S Woo and W Kim.

in Cardiovascular Research

April 2018; p ublished online April 2018 .

Journal Article. Subjects: Cardiovascular Medicine. 308 words.

792 Cardiorenal actions of the new direct soluble guanylate cyclase activator BAY 58-2667 in experimental congestive heart failure

G. Boerrigter, L.C. Costello-Boerrigter, A. Cataliotti, T. Tsuruda, G.J. Harty, H. Lapp, J.P. Stasch and J.C. Burnett.

in European Journal of Heart Failure Supplements

June 2003; p ublished online June 2003 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

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33 The soluble guanylate cyclase activator BAY 58-2667 has a favourable safety profile and improves cardiopulmonary haemodynamics in acute decompensated heart failure

V. Mitrovic, H. Lapp, N. Franz, H. Heuer, M. Buerke, J. Wolfertz, W. Mueck, S. Unger, G. Wensing and R. Frey.

in European Journal of Heart Failure Supplements

June 2008; p ublished online June 2008 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

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320 Determinants of BNP (Bayer) and NT-proBNP (Roche) in patients with suspected heart failure: A comprehensive and validated analysis

K. Goode, A.L. Clark, E.S. Kilpatrick, C.P. Price and J.G. Cleland.

in European Journal of Heart Failure Supplements

June 2008; p ublished online June 2008 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

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468 Additional particulate guanylate cyclase activation with BNP does not augment the hemodynamic actions of the direct soluble guanylate cyclase activator BAY 58-2667 but it enhances renal function

G. Boerrigter, L.C. Costello-Boerrigter, H. Lapp, G.J. Harty, J.P. Stasch and J.C. Burnett.

in European Journal of Heart Failure Supplements

June 2004; p ublished online June 2004 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

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Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection

Javier Inserte, Víctor Hernando, Marisol Ruiz-Meana, Marcos Poncelas-Nozal, Celia Fernández, Luis Agulló, Carmem Sartorio, Úrsula Vilardosa and David Garcia-Dorado.

in Cardiovascular Research

September 2014; p ublished online June 2014 .

Journal Article. Subjects: Cardiovascular Medicine. 6274 words.

Aims

It has been shown that sarcoplasmic reticulum calcium ATPase (SERCA) plays a critical role in reperfusion injury. Moreover, ischaemic post-conditioning...

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NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size

Justin S. Bice, Yvonne Keim, Johannes-Peter Stasch and Gary F. Baxter.

in Cardiovascular Research

February 2014; p ublished online November 2013 .

Journal Article. Subjects: Cardiovascular Medicine. 5155 words.

Aims

Guanylyl cyclase-cyclic guanosine monophosphate signalling plays an important role in endogenous cardioprotective signalling. The aim was to assess the...

Go to »  full text: open access   » abstract

Modulation of myocardial economy and efficiency in mammalian failing and non-failing myocardium by calcium channel activation and β-adrenergic stimulation

Thorsten Ruf, Siegbert Hebisch, Rainer Groß, Norman Alpert, Hanjörg Just and Christian Holubarsch.

in Cardiovascular Research

December 1996 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Objective:

We investigated the energy-metabolic consequences of positive inotropic stimulation by the calcium channel activator, BAY K 8644, in comparison...

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Differential roles of myocardial Ca2+ channels and Na+/Ca2+ exchange in myocardial reperfusion injury in open chest dogs: relative roles during ischemia and reperfusion

Steven C Smart, Kiran B Sagar and David C Warltier.

in Cardiovascular Research

December 1997; p ublished online December 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 7138 words.

Abstract

Objective: Compare the roles of Ca2+ channels and Na+/Ca2+ exchange in reperfusion injury (reperfusion ventricular fibrillation and...

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Functional role of the soluble guanylyl cyclase α1 subunit in vascular smooth muscle relaxation

Sofie Nimmegeers, Patrick Sips, Emmanuel Buys, Peter Brouckaert and Johan Van de Voorde.

in Cardiovascular Research

October 2007; p ublished online October 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 5343 words.

Abstract

Objective Soluble guanylyl cyclase (sGC), the predominant receptor for nitric oxide (NO), exists in 2 active isoforms (α2β1 and α1β1)....

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P112Calcium channels influence of mifipristone vasorelaxation on vascular smooth muscle cells

M Mariana, J Feiteiro, I Verde and E Cairrao.

in Cardiovascular Research

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Cardiovascular Medicine. 0 words.

Introduction: Mifepristone (RU 486) is a compound derived from the estrane progestins and related to steroid hormones. It was the first synthetic steroid of this class employed...

Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis

Evgeny P. Anyukhovsky, Eugene A. Sosunov, Alexei Plotnikov, Ravil Z. Gainullin, Jeffrey S. Jhang, Charles C. Marboe and Michael R. Rosen.

in Cardiovascular Research

May 2002; p ublished online May 2002 .

Journal Article. Subjects: Cardiovascular Medicine. 4887 words.

Abstract

Objective: The incidence of atrial fibrillation increases with age. We hypothesized that aging-associated changes in the atrial action...

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Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design

Stefano Ghio, Diana Bonderman, Stephan B. Felix, Hossein A. Ghofrani, Evangelos D. Michelakis, Veselin Mitrovic, Ronald J. Oudiz, Reiner Frey, Lothar Roessig and Marc J. Semigran.

in European Journal of Heart Failure

August 2012; p ublished online June 2012 .

Journal Article. Subjects: Cardiovascular Medicine. 4700 words.

Aims

Pulmonary hypertension (PH) due to systolic left ventricular dysfunction (PH-sLVD) frequently complicates heart failure (HF), and greatly worsens the...

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Signalling mechanisms underlying the myogenic response in human subcutaneous resistance arteries

Paul Coats, Fiona Johnston, John MacDonald, John J. McMurray and Chris Hillier.

in Cardiovascular Research

March 2001; p ublished online March 2001 .

Journal Article. Subjects: Cardiovascular Medicine. 5016 words.

Abstract

Objective: In this study we have examined for the first time the signal transduction mechanisms involved in the generation of...

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Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells

Narimasa Miho, Takafumi Ishida, Noriko Kuwaba, Mari Ishida, Keiko Shimote-Abe, Kumiko Tabuchi, Tetsuya Oshima, Masao Yoshizumi and Kazuaki Chayama.

in Cardiovascular Research

November 2005; p ublished online November 2005 .

Journal Article. Subjects: Cardiovascular Medicine. 6105 words.

Abstract

Objective: Thrombin induces leukocyte adherence to endothelial cells via increased expression of intercellular adhesion molecule-1...

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Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway

Anirban Bhattachariya, Diana Dahan, Karolina M. Turczyńska, Karl Swärd, Per Hellstrand and Sebastian Albinsson.

in Cardiovascular Research

February 2014; p ublished online November 2013 .

Journal Article. Subjects: Cardiovascular Medicine. 5662 words.

Aims

The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have...

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Reverse rate dependency is an intrinsic property of canine cardiac preparations

Tamás Bányász, Balázs Horváth, László Virág, László Bárándi, Norbert Szentandrássy, Gábor Harmati, János Magyar, Stefano Marangoni, Antonio Zaza, András Varró and Péter P. Nánási.

in Cardiovascular Research

November 2009; p ublished online June 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4966 words.

Aims

Class III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action potential duration (APD). In spite of the several theories...

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