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DNA fingerprint

Overview page. Subjects: Ecology and Conservation.

A set of DNA-based characters which are in a combination unique, or nearly so, to an individual organism. See also satellite DNA.

See overview in Oxford Index

The Constitutive Active/Androstane Receptor Facilitates Unique Phenobarbital-Induced Expression Changes of Genes Involved in Key Pathways in Precancerous Liver and Liver Tumors

Jennifer M. Phillips, Lyle D. Burgoon and Jay I. Goodman.

in Toxicological Sciences

August 2009; p ublished online May 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 11313 words.

Our overall goal is to elucidate progressive changes, in expression and methylation status, of genes which play key roles in phenobarbital (PB)–induced liver tumorigenesis, with an emphasis...

Toxicogenomics-Based Discrimination of Toxic Mechanism in HepG2 Human Hepatoma Cells

Michael E. Burczynski, Michael McMillian, Joe Ciervo, Li Li, James B. Parker, Robert T. Dunn, Sam Hicken, Spencer Farr and Mark D. Johnson.

in Toxicological Sciences

December 2000; p ublished online December 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8259 words.

The rapid discovery of sequence information from the Human Genome Project has exponentially increased the amount of data that can be retrieved from biomedical experiments. Gene expression...

Identification of a Transcriptional Fingerprint of Estrogen Exposure in Rainbow Trout Liver

Abby D. Benninghoff and David E. Williams.

in Toxicological Sciences

January 2008; p ublished online September 2007 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8826 words.

The goal of this study was to identify a set of hepatic genes regulated by ligand-dependent activation of the estrogen receptor in juvenile rainbow trout (Oncorhynchus mykiss). A custom...

Multiple Genes Exhibit Phenobarbital-Induced Constitutive Active/Androstane Receptor–Mediated DNA Methylation Changes during Liver Tumorigenesis and in Liver Tumors

Jennifer M. Phillips and Jay I. Goodman.

in Toxicological Sciences

April 2009; p ublished online February 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 10588 words.

The constitutive active/androstane receptor (CAR) mediates responses to the nongenotoxic rodent liver tumor promoter phenobarbital (PB), including certain gene expression changes,...

Phenobarbital Elicits Unique, Early Changes in the Expression of Hepatic Genes that Affect Critical Pathways in Tumor-Prone B6C3F1 Mice

Jennifer M. Phillips, Lyle D. Burgoon and Jay I. Goodman.

in Toxicological Sciences

June 2009; p ublished online March 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9490 words.

At 2 and 4 weeks following treatment with phenobarbital (PB), the classical nongenotoxic rodent liver carcinogen, we elucidated unique gene expression changes (both induction and...