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founder

Overview page. Subjects: Warfare and Defence — Maritime History.

Of a ship, to sink at sea, generally understood to be by the flooding of its hull either through springing a leak or through striking a rock. Other causes of a ship sinking, such as...

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Mathematical Modeling of Cortical Neurogenesis Reveals that the Founder Population does not Necessarily Scale with Neurogenic Output

Noemi Picco, Fernando García-Moreno, Philip K Maini, Thomas E Woolley and Zoltán Molnár.

in Cerebral Cortex

July 2018; p ublished online April 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Neuroscience. 7506 words.

Abstract

The mammalian cerebral neocortex has a unique structure, composed of layers of different neuron types, interconnected in a stereotyped fashion. While...

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0136 Evaluation of MRI-Based Soft-Tissue and Craniofacial Phenotypes in Diversity Outbred Mice and Founder Strains

T T Nguyen, B T Keenan, R Galante, A S Wiemken, T C Lin, N Azad, L A Brake, R J Schwab and A I Pack.

in SLEEP

P ublished online April 2018 .

Journal Article. Subjects: Neurology; Sleep Medicine; Clinical Neuroscience; Neuroscience. 0 words.

Abstract

Introduction

Increased volume of upper airway soft-tissues, tongue fat deposition, and restricted...

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0325 High-Throughput Sleep Phenotyping and Heritability in Diversity Outbred Mice

B T Keenan, R Galante, J Lian, P Simecek, D M Gatti, L Zhang, D C Lim, K L Svenson, G Churchill and A I Pack.

in SLEEP

P ublished online April 2018 .

Journal Article. Subjects: Neurology; Sleep Medicine; Clinical Neuroscience; Neuroscience. 0 words.

Abstract

Introduction

High-throughput phenotyping is essential for genetic association studies in outbred mouse...

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Intravenous Administration of a MTMR2-Encoding AAV Vector Ameliorates the Phenotype of Myotubular Myopathy in Mice

Nathalie Danièle, Christelle Moal, Laura Julien, Martina Marinello, Thibaud Jamet, Samia Martin, Alban Vignaud, Michael W Lawlor and Ana Buj-Bello.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 7886 words.

Abstract

X-linked myotubular myopathy (XLMTM) is a severe congenital disorder in male infants that leads to generalized skeletal muscle weakness and is...

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