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founder

Overview page. Subjects: Warfare and Defence — Maritime History.

Of a ship, to sink at sea, generally understood to be by the flooding of its hull either through springing a leak or through striking a rock. Other causes of a ship sinking, such as...

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Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein

Lars Krüger, Ilja Demuth, Heidemarie Neitzel, Raymonda Varon, Karl Sperling, Krystyna H. Chrzanowska, Eva Seemanova and Martin Digweed.

in Carcinogenesis

June 2006; p ublished online January 2007 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 3417 words.

The human genetic disorder, Nijmegen breakage syndrome (NBS), is characterized by radiosensitivity, immunodeficiency and an increased risk for cancer, particularly B-cell non-Hodgkin...

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Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers

Cezary Cybulski, Bartłomiej Masojć, Dorota Oszutowska, Ewa Jaworowska, Tomasz Grodzki, Piotr Waloszczyk, Piotr Serwatowski, Juliusz Pankowski, Tomasz Huzarski, Tomasz Byrski, Bohdan Górski, Anna Jakubowska, Tadeusz Dębniak, Dominika Wokołorczyk, Jacek Gronwald, Czesława Tarnowska, Pablo Serrano-Fernández, Jan Lubiński and Steven A. Narod.

in Carcinogenesis

April 2008; p ublished online February 2008 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 3149 words.

Mutations in the CHEK2 gene have been associated with increased risks of breast, prostate and colon cancer. In contrast, a previous report suggests that individuals with the I157T missense...

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The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative

Juana V. Martín-López, Ysamar Barrios, Vicente Medina-Arana, Miguel Andújar, Sanghee Lee, Liya Gu, Guo-Min Li, Josef Rüschoff, Eduardo Salido and Richard Fishel.

in Carcinogenesis

September 2012; p ublished online June 2012 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6588 words.

The hMSH2(M688R) mismatch repair (MMR) gene mutation has been found in five large families from Tenerife, Spain, suggesting it is a Lynch syndrome or hereditary non-polyposis colorectal...

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RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

Katri Heikkinen, Katrin Rapakko, Sanna-Maria Karppinen, Hannele Erkko, Sakari Knuutila, Tuija Lundán, Arto Mannermaa, Anne-Lise Børresen-Dale, Åke Borg, Rosa B. Barkardottir, John Petrini and Robert Winqvist.

in Carcinogenesis

P ublished online February 2006 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 4295 words.

The Mre11 complex, composed of RAD50, NBS1 and MRE11, has an essential role in the maintenance of genomic integrity and preventing cells from malignancy. Here we report the association of...

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S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion

Chenxu Shi, Timothy K. Cooper, Diane E. McCloskey, Adam B. Glick, Lisa M. Shantz and David J. Feith.

in Carcinogenesis

July 2012; p ublished online May 2012 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6992 words.

Neoplastic growth is associated with increased polyamine biosynthetic activity and content. Tumor promoter treatment induces the rate-limiting enzymes in polyamine biosynthesis, ornithine...

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The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial

Zhuo Chen, Celia Greenwood, William B. Isaacs, William D. Foulkes, Jielin Sun, Sigun L. Zheng, Lynn D. Condreay and Jianfeng Xu.

in Carcinogenesis

June 2013; p ublished online February 2013 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 3972 words.

A novel rare mutation, homeobox B13 (HOXB13) G84E, was reported to co-segregate with prostate cancer (PCa) in hereditary PCa families and associate with PCa risk in unrelated cases and...

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Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells

Bruna Corominas-Faja, Elisabet Cuyàs, Jesús Lozano-Sánchez, Sílvia Cufí, Sara Verdura, Salvador Fernández-Arroyo, Isabel Borrás-Linares, Begoña Martin-Castillo, Ángel G Martin, Ruth Lupu, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Vicente Micol, Jorge Joven, Antonio Segura-Carretero and Javier A Menendez.

in Carcinogenesis

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 8984 words.

Abstract

Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and...

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Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: translational implications and mechanism of action

Denise Perry Simmons, Megan L. Peach, Jonathan R. Friedman, Michael M.B. Green, Marc C. Nicklaus and Luigi M. De Luca.

in Carcinogenesis

April 2006; p ublished online October 2005 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 9857 words.

LRAT (lecithin:retinol acyltransferase), an enzyme whose levels are modulated during malignant conversion, has been reported as the founder member of a new LRAT-like family that includes...

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Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer

Katri Pylkäs, Johanna Tommiska, Kirsi Syrjäkoski, Juha Kere, Magtouf Gatei, Nicola Waddell, Minna Allinen, Sanna-Maria Karppinen, Katrin Rapakko, Helena Kääriäinen, Kristiina Aittomäki, Carl Blomqvist, Aki Mustonen, Kaija Holli, Kum Kum Khanna, Olli-Pekka Kallioniemi, Heli Nevanlinna and Robert Winqvist.

in Carcinogenesis

May 2007; p ublished online December 2006 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 4512 words.

Biallelic mutations in the ataxia-telangiectasia mutated (ATM) gene result in ataxia-telangiectasia (A-T). Studies on A-T families have shown that obligate female carriers have increased...

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LRPPRC mutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population

Monika Oláhová, Steven A. Hardy, Julie Hall, John W. Yarham, Tobias B. Haack, William C. Wilson, Charlotte L. Alston, Langping He, Erik Aznauryan, Ruth M. Brown, Garry K. Brown, Andrew A. M. Morris, Helen Mundy, Alex Broomfield, Ines A. Barbosa, Michael A. Simpson, Charu Deshpande, Dorothea Moeslinger, Johannes Koch, Georg M. Stettner, Penelope E. Bonnen, Holger Prokisch, Robert N. Lightowlers, Robert McFarland, Zofia M. A. Chrzanowska-Lightowlers and Robert W. Taylor.

in Brain

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cellular Systems. 9524 words.

Mitochondrial Complex IV [cytochrome c oxidase (COX)] deficiency is one of the most common respiratory chain defects in humans. The clinical phenotypes associated with COX deficiency...

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EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy

Susan Byrne, Lara Jansen, Jean-Marie U-King-Im, Ata Siddiqui, Hart G. W. Lidov, Istvan Bodi, Luke Smith, Rachael Mein, Thomas Cullup, Carlo Dionisi-Vici, Lihadh Al-Gazali, Mohammed Al-Owain, Zandre Bruwer, Khalid Al Thihli, Rana El-Garhy, Kevin M. Flanigan, Kandamurugu Manickam, Erik Zmuda, Wesley Banks, Ruth Gershoni-Baruch, Hanna Mandel, Efrat Dagan, Annick Raas-Rothschild, Hila Barash, Francis Filloux, Donnell Creel, Michael Harris, Ada Hamosh, Stefan Kölker, Darius Ebrahimi-Fakhari, Georg F. Hoffmann, David Manchester, Philip J. Boyer, Adnan Y. Manzur, Charles Marques Lourenco, Daniela T. Pilz, Arveen Kamath, Prab Prabhakar, Vamshi K. Rao, R. Curtis Rogers, Monique M. Ryan, Natasha J. Brown, Catriona A. McLean, Edith Said, Ulrike Schara, Anja Stein, Caroline Sewry, Laura Travan, Frits A. Wijburg, Martin Zenker, Shehla Mohammed, Manolis Fanto, Mathias Gautel and Heinz Jungbluth.

in Brain

March 2016; p ublished online February 2016 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Molecular and Cellular Systems. 8733 words.

Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological, and...

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