Oxford Index Search Results

You are looking at 1-20 of 40 items for:

decision-making x Biochemistry x clear all

Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making

Yu-Mei Tan, Rachel R Worley, Jeremy A Leonard and Jeffrey W Fisher.

in Toxicological Sciences

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6496 words.

Abstract

The development and application of physiologically based pharmacokinetic (PBPK) models in chemical toxicology have grown steadily since their...

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Risk Characterization: A Bridge to Informed Decision Making

Edward V. Ohanian, John A. Moore, John R. Fowle, Gilbert S. Omenn, Steven C. Lewis, George M. Gray and D. Warner North.

in Toxicological Sciences

October 1997; p ublished online October 1997 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Regulatory decisions should be made in the most expert and informed way since they are precipitated by real and perceived threats to human health, under the glare of public scrutiny. In...

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Corrigendum to “Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making”

Yu-Mei Tan, Rachel Worley, Jeremy A Leonard and Jeffrey Fisher.

in Toxicological Sciences

April 2018; p ublished online March 2018 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 143 words.

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Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging

Maria Jose Martin and Luis Blanco.

in Nucleic Acids Research

July 2014; p ublished online May 2014 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8310 words.

Human Polμ is a DNA polymerase belonging to the X family that has been implicated in the non-homologous end-joining (NHEJ) pathway during repair of double-strand breaks in DNA. Loop1 is a...

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Getting a macromolecular model: model building, refinement, and validation

R. J. Morris, A. Perrakis and V. S. Lamzin.

in Macromolecular Crystallography

August 2007; p ublished online September 2007 .

Chapter. Subjects: Biochemistry. 11259 words.

This chapter casts the high-throughput automation efforts being developed to meet the needs of Structural Genomics initiatives in the framework of an optimization problem. It gives a...

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Qrator: A web-based curation tool for glycan structures

Matthew Eavenson, Krys J Kochut, John A Miller, René Ranzinger, Michael Tiemeyer, Kazuhiro Aoki and William S York.

in Glycobiology

January 2015; p ublished online August 2014 .

Journal Article. Subjects: Carbohydrates. 5673 words.

Most currently available glycan structure databases use their own proprietary structure representation schema and contain numerous annotation errors. These cause problems when glycan...

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Detection of allogeneic blood group A and B enzyme activities in patients with ABO incompatible kidney transplantation

Masayuki Tasaki, Tamiko Nakajima, Naofumi Imai, Yuki Nakagawa, Kazuhide Saito, Kota Takahashi and Shin Yazawa.

in Glycobiology

October 2010; p ublished online June 2010 .

Journal Article. Subjects: Carbohydrates. 5647 words.

The phenomenon of accommodation in recipients of blood group ABO incompatible kidney transplantation (iKTx), in which grafts survive despite the presence of blood group A or B antigen in...

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Probabilistic Exposure Analysis for Chemical Risk Characterization

Kenneth T. Bogen, Alison C. Cullen, H. Christopher Frey and Paul S. Price.

in Toxicological Sciences

May 2009; p ublished online February 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 12666 words.

This paper summarizes the state of the science of probabilistic exposure assessment (PEA) as applied to chemical risk characterization. Current probabilistic risk analysis methods applied...

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The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives

Ivan Rusyn and Nigel Greene.

in Toxicological Sciences

February 2018; p ublished online September 2017 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6714 words.

Abstract

The field of experimental toxicology is rapidly advancing by incorporating novel techniques and methods that provide a much more granular view into...

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Enhancing the Credibility of Decisions Based on Scientific Conclusions: Transparency Is Imperative

Jay Schreider, Craig Barrow, Norman Birchfield, Kerry Dearfield, Dennis Devlin, Sara Henry, Melissa Kramer, Seema Schappelle, Keith Solomon, Douglas L. Weed and Michelle R. Embry.

in Toxicological Sciences

July 2010; p ublished online April 2010 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 1893 words.

Transparency and documentation of the decision process are at the core of a credible risk assessment and, in addition, are essential in the presentation of a weight of evidence (WoE)–based...

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Toxicogenomics in Risk Assessment: Applications and Needs

Darrell R. Boverhof and Timothy R. Zacharewski.

in Toxicological Sciences

February 2006; p ublished online October 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6402 words.

Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment process by providing valuable...

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Identification and Characterization of Adverse Effects in 21st Century Toxicology

Douglas A. Keller, Daland R. Juberg, Natasha Catlin, William H. Farland, Frederick G. Hess, Douglas C. Wolf and Nancy G. Doerrer.

in Toxicological Sciences

April 2012; p ublished online January 2012 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5147 words.

The practice of toxicology is changing rapidly, as demonstrated by the response to the 2007 NRC report on “Toxicity Testing in the 21st Century.” New assays are being developed to replace...

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A system's approach to dissecting immunity (LL4-2)

A. Aderem.

in International Immunology Meeting Abstracts

August 2010; p ublished online August 2010 .

Journal Article. Subjects: Immunology; Biochemical Immunology. 0 words.

Macrophages and dendritic cells represent one of the cornerstones of the innate immune system. They detect infectious organisms and then orchestrate an appropriate host response to them. In...

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Intensity of the Internal Standard Response as the Basis for Reporting a Test Specimen as Negative or Inconclusive

Ray H. Liu, Chih-Hung Wu, Yi-Jun Chen, Chiung-Dan Chang, Jason G. Linville and Dennis V. Canfield.

in Journal of Analytical Toxicology

November 2007; p ublished online November 2007 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Under normal circumstances, a test specimen is reported as “negative” when the response of the analyte is absent. However, if the intensity of the internal standard (IS) is low, indicating...

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Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat

Mark R. Fielden, Alex Nie, Michael McMillian, Chandi S. Elangbam, Bruce A. Trela, Yi Yang, Robert T. Dunn, Yvonne Dragan, Ronny Fransson-Stehen, Matthew Bogdanffy, Stephen P. Adams, William R. Foster, Shen-Jue Chen, Phil Rossi, Peter Kasper, David Jacobson-Kram, Kay S. Tatsuoka, Patrick J. Wier, Jeremy Gollub, Donald N. Halbert, Alan Roter, Jamie K. Young, Joseph F. Sina, Jennifer Marlowe, Hans-Joerg Martus, Jiri Aubrecht, Andrew J. Olaharski, Nigel Roome, Paul Nioi, Ingrid Pardo, Ron Snyder, Richard Perry, Peter Lord, William Mattes and Bruce D. Car.

in Toxicological Sciences

May 2008; p ublished online February 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5074 words.

The Critical Path Institute recently established the Predictive Safety Testing Consortium, a collaboration between several companies and the U.S. Food and Drug Administration, aimed at...

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Adverse Outcome Pathway Development II: Best Practices

Daniel L. Villeneuve, Doug Crump, Natàlia Garcia-Reyero, Markus Hecker, Thomas H. Hutchinson, Carlie A. LaLone, Brigitte Landesmann, Teresa Lettieri, Sharon Munn, Malgorzata Nepelska, Mary Ann Ottinger, Lucia Vergauwen and Maurice Whelan.

in Toxicological Sciences

December 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8208 words.

Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived...

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Predicting Drug Safety and Communicating Risk: Benefits of a Bayesian Approach

Stanley E Lazic, Nicholas Edmunds and Christopher E Pollard.

in Toxicological Sciences

March 2018; p ublished online November 2017 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6199 words.

Abstract

Drug toxicity is a major source of attrition in drug discovery and development. Pharmaceutical companies routinely use preclinical data to predict...

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Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay

Abhijit Saha, Seiichiro Kizaki, Debojyoti De, Masayuki Endo, Kyeong Kyu Kim and Hiroshi Sugiyama.

in Nucleic Acids Research

August 2016; p ublished online May 2016 .

Journal Article. Subjects: Proteins; Molecular Biology and Genetics. 6316 words.

Functional cooperativity among transcription factors on regulatory genetic elements is pivotal for milestone decision-making in various cellular processes including mammalian development....

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Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence

Edward J. Perkins, Philipp Antczak, Lyle Burgoon, Francesco Falciani, Natàlia Garcia-Reyero, Steve Gutsell, Geoff Hodges, Aude Kienzler, Dries Knapen, Mary McBride and Catherine Willett.

in Toxicological Sciences

November 2015; p ublished online October 2015 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8332 words.

Adverse outcome pathways (AOPs) offer a pathway-based toxicological framework to support hazard assessment and regulatory decision-making. However, little has been discussed about the...

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The Value of DNA Methylation Analysis in Basic, Initial Toxicity Assessments

Rebecca E. Watson, James M. McKim, Gary L. Cockerell and Jay I. Goodman.

in Toxicological Sciences

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7090 words.

DNA methylation is an epigenetic mechanism regulating patterns of gene expression. Our goal was to see if the assessment of DNA methylation might be a useful tool, when used in conjunction...

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