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decision-making x Neurology x Neuroscience x Psychiatry x clear all

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Effect of Psilocybin on Empathy and Moral Decision-Making

Thomas Pokorny, Katrin H Preller, Michael Kometer, Isabel Dziobek and Franz X Vollenweider.

in International Journal of Neuropsychopharmacology

P ublished online June 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7740 words.

Abstract

Background

Impaired empathic abilities lead to severe negative social consequences and influence the...

Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease

Campbell Le Heron, Sanjay Manohar, Olivia Plant, Kinan Muhammed, Ludovica Griffanti, Andrea Nemeth, Gwenaëlle Douaud, Hugh S Markus and Masud Husain.

in Brain

November 2018; p ublished online October 2018 .

Journal Article. Subjects: Neuroscience; Neurology; Psychiatry. 11885 words.

Abstract

Apathy is a syndrome of reduced motivation that commonly occurs in patients with cerebral small vessel disease, including those with the early onset...

Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson’s disease

Campbell Le Heron, Olivia Plant, Sanjay Manohar, Yuen-Siang Ang, Matthew Jackson, Graham Lennox, Michele T Hu and Masud Husain.

in Brain

May 2018; p ublished online April 2018 .

Journal Article. Subjects: Neuroscience; Neurology; Psychiatry. 9210 words.

Abstract

Effort-based decision-making is a cognitive process crucial to normal motivated behaviour. Apathy is a common and disabling complication of...

Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making

Paul Faulkner, Federico Mancinelli, Patricia L Lockwood, Mar Matarin, Raymond J Dolan, Nick W Wood, Peter Dayan and Jonathan P Roiser.

in International Journal of Neuropsychopharmacology

P ublished online September 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 6846 words.

Abstract

Background

The effects of acute tryptophan depletion on human decision-making suggest that serotonin...

PM300. Impaired fronto-insular activation during risky decision making in young adults with internet gaming disorder

in International Journal of Neuropsychopharmacology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 313 words.

Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

John D. Salamone, Samantha E. Yohn, Laura López-Cruz, Noemí San Miguel and Mercè Correa.

in Brain

May 2016; p ublished online April 2016 .

Journal Article. Subjects: Neuroscience; Neurology; Psychiatry. 18091 words.

Motivation is critical for survival, and involves multiple behavioural functions mediated by a number of interacting neural circuits. Salamone et al. review basic neuroscience research,...

A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder

Arjun Sethi, Valerie Voon, Hugo D Critchley, Mara Cercignani and Neil A Harrison.

in Brain

May 2018; p ublished online March 2018 .

Journal Article. Subjects: Neuroscience; Neurology; Psychiatry. 8655 words.

Abstract

Computational models of reinforcement learning have helped dissect discrete components of reward-related function and characterize neurocognitive...

Smaller amygdala and medial prefrontal cortex predict escalating stimulant use

Benjamin Becker, Daniel Wagner, Philip Koester, Marc Tittgemeyer, Katja Mercer-Chalmers-Bender, René Hurlemann, Jie Zhang, Euphrosyne Gouzoulis-Mayfrank, Keith M. Kendrick and Joerg Daumann.

in Brain

July 2015; p ublished online May 2015 .

Journal Article. Subjects: Neuroscience; Neurology; Psychiatry. 7626 words.

Drug addiction is a chronic, relapsing brain disorder. The identification of biomarkers that render individuals vulnerable for the transition from occasional drug use to addiction is of key...

Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report

Tetsuya Suhara, Shigeyuki Chaki, Haruhide Kimura, Makoto Furusawa, Mitsuyuki Matsumoto, Hiroo Ogura, Takaaki Negishi, Takeaki Saijo, Makoto Higuchi, Tomohiro Omura, Rira Watanabe, Sosuke Miyoshi, Noriaki Nakatani, Noboru Yamamoto, Shyh-Yuh Liou, Yuhei Takado, Jun Maeda, Yasumasa Okamoto, Yoshiaki Okubo, Makiko Yamada, Hiroshi Ito, Noah M. Walton and Shigeto Yamawaki.

in International Journal of Neuropsychopharmacology

P ublished online December 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7350 words.

Abstract

Despite large unmet medical needs in the field for several decades, CNS drug discovery and development has been largely unsuccessful. Biomarkers,...

Social Cognition and Interaction in Chronic Users of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Michael D Wunderli, Matthias Vonmoos, Lorena Treichler, Carmen Zeller, Isabel Dziobek, Thomas Kraemer, Markus R Baumgartner, Erich Seifritz and Boris B Quednow.

in International Journal of Neuropsychopharmacology

P ublished online November 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 9163 words.

Abstract

Background

The empathogen 3,4-methylenedioxymethamphetamine (MDMA) is the prototypical prosocial club drug...