Oxford Index Search Results

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decision-making x Biological Sciences x Clinical Cytogenetics and Molecular Genetics x clear all

Genetic toxicology at the crossroads—from qualitative hazard evaluation to quantitative risk assessment

Paul A. White and George E. Johnson.

in Mutagenesis

May 2016; p ublished online March 2016 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 4363 words.

Applied genetic toxicology is undergoing a transition from qualitative hazard identification to quantitative dose–response analysis and risk assessment. To facilitate this change, the...

Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans

Tarjinder Sahota, Meindert Danhof and Oscar Della Pasqua.

in Mutagenesis

May 2016; p ublished online March 2016 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 14534 words.

Despite ongoing efforts to better understand the mechanisms underlying safety and toxicity, ~30% of the attrition in drug discovery and development is still due to safety concerns. Changes...

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data

Jeffrey C. Bemis, John W. Wills, Steven M. Bryce, Dorothea K. Torous, Stephen D. Dertinger and Wout Slob.

in Mutagenesis

May 2016; p ublished online June 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 5460 words.

The application of flow cytometry as a scoring platform for both in vivo and in vitro micronucleus (MN) studies has enabled the efficient generation of high quality datasets suitable for...

MutAIT: an online genetic toxicology data portal and analysis tools

Daniele Avancini, Georgina E. Menzies, Claire Morgan, John Wills, George E. Johnson, Paul A. White and Paul D. Lewis.

in Mutagenesis

May 2016; p ublished online July 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 2584 words.

Assessment of genetic toxicity and/or carcinogenic activity is an essential element of chemical screening programs employed to protect human health. Dose–response and gene mutation data are...

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations

John W. Wills, George E. Johnson, Shareen H. Doak, Lya G. Soeteman-Hernández, Wout Slob and Paul A. White.

in Mutagenesis

May 2016; p ublished online December 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 6412 words.

Genetic toxicity testing has traditionally been used for hazard identification, with dichotomous classification of test results serving to identify genotoxic agents. However, the utility of...

Clinically Significant Molecular Markers for Urologic Disease: Focus on Bladder, Kidney, and Prostate Cancer

Lance P. Walsh and Yair Lotan.

in Laboratory Medicine

July 2006; p ublished online September 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Chemistry; Molecular and Cell Biology; Molecular Biology and Genetics. 0 words.

The most important tools for making therapeutic decisions include stage and grade for bladder and kidney cancer, as well as PSA for prostate cancer. Unfortunately, all tumors of the same...