Oxford Index Search Results

You are looking at 1-20 of 26 items for:

decision-making x Biological Sciences x Genetics and Genomics x clear all

Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging

Maria Jose Martin and Luis Blanco.

in Nucleic Acids Research

July 2014; p ublished online May 2014 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8310 words.

Human Polμ is a DNA polymerase belonging to the X family that has been implicated in the non-homologous end-joining (NHEJ) pathway during repair of double-strand breaks in DNA. Loop1 is a...

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Pedimap: Software for the Visualization of Genetic and Phenotypic Data in Pedigrees

Roeland E. Voorrips, Marco C. A. M. Bink and W. Eric van de Weg.

in Journal of Heredity

January 2012; p ublished online October 2012 .

Journal Article. Subjects: Genetics and Genomics. 1753 words.

Pedimap is a user-friendly software tool for visualizing phenotypic and genotypic data for related individuals linked in pedigrees. Genetic data can include marker scores,...

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Evidence-based medicine and big genomic data

John P A Ioannidis and Muin J Khoury.

in Human Molecular Genetics

May 2018; p ublished online February 2018 .

Journal Article. Subjects: Genetics and Genomics. 4737 words.

Abstract

Genomic and other related big data (Big Genomic Data, BGD for short) are ushering a new era of precision medicine. This overview discusses whether...

A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret

Samantha M. Wisely, Oliver A. Ryder, Rachel M. Santymire, John F. Engelhardt and Ben J. Novak.

in Journal of Heredity

January 2015; p ublished online August 2015 .

Journal Article. Subjects: Genetics and Genomics. 11061 words.

Interspecies somatic cell nuclear transfer (iSCNT) could benefit recovery programs of critically endangered species but must be weighed with the risks of failure. To weigh the risks and...

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Identifying Genetic Hotspots by Mapping Molecular Diversity of Widespread Trees: When Commonness Matters

Cintia P. Souto, Paula Mathiasen, María Cristina Acosta, María Paula Quiroga, Romina Vidal-Russell, Cristian Echeverría and Andrea C. Premoli.

in Journal of Heredity

September 2015; p ublished online August 2015 .

Journal Article. Subjects: Genetics and Genomics. 6068 words.

Conservation planning requires setting priorities at the same spatial scale at which decision-making processes are undertaken considering all levels of biodiversity, but current methods for...

Genetics of neurodegenerative diseases: insights from high-throughput resequencing

Shoji Tsuji.

in Human Molecular Genetics

April 2010; p ublished online April 2010 .

Journal Article. Subjects: Genetics and Genomics. 3194 words.

During the past three decades, we have witnessed remarkable advances in our understanding of the molecular etiologies of hereditary neurodegenerative diseases, which have been accomplished...

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Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population

Takeshi Ozeki, Taisei Mushiroda, Amara Yowang, Atsushi Takahashi, Michiaki Kubo, Yuji Shirakata, Zenro Ikezawa, Masafumi Iijima, Tetsuo Shiohara, Koji Hashimoto, Naoyuki Kamatani and Yusuke Nakamura.

in Human Molecular Genetics

March 2011; p ublished online December 2010 .

Journal Article. Subjects: Genetics and Genomics. 4617 words.

An anticonvulsant, carbamazepine (CBZ), is known to show incidences of cutaneous adverse drug reactions (cADRs) including Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN)...

Gene expression profiles of poor-prognosis primary breast cancer correlate with survival

François Bertucci, Valéry Nasser, Samuel Granjeaud, François Eisinger, José Adelaïde, Rebecca Tagett, Béatrice Loriod, Aurélia Giaconia, Athmane Benziane, Elisabeth Devilard, Jocelyne Jacquemier, Patrice Viens, Catherine Nguyen, Daniel Birnbaum and Rémi Houlgatte.

in Human Molecular Genetics

April 2002; p ublished online April 2002 .

Journal Article. Subjects: Genetics and Genomics. 6652 words.

The extensive heterogeneity of breast cancer complicates the precise assessment of tumour aggressiveness, making therapeutic decisions difficult and treatments inappropriate in some cases....

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Genetic toxicology at the crossroads—from qualitative hazard evaluation to quantitative risk assessment

Paul A. White and George E. Johnson.

in Mutagenesis

May 2016; p ublished online March 2016 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 4363 words.

Applied genetic toxicology is undergoing a transition from qualitative hazard identification to quantitative dose–response analysis and risk assessment. To facilitate this change, the...

Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans

Tarjinder Sahota, Meindert Danhof and Oscar Della Pasqua.

in Mutagenesis

May 2016; p ublished online March 2016 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 14534 words.

Despite ongoing efforts to better understand the mechanisms underlying safety and toxicity, ~30% of the attrition in drug discovery and development is still due to safety concerns. Changes...

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data

Jeffrey C. Bemis, John W. Wills, Steven M. Bryce, Dorothea K. Torous, Stephen D. Dertinger and Wout Slob.

in Mutagenesis

May 2016; p ublished online June 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 5460 words.

The application of flow cytometry as a scoring platform for both in vivo and in vitro micronucleus (MN) studies has enabled the efficient generation of high quality datasets suitable for...

MutAIT: an online genetic toxicology data portal and analysis tools

Daniele Avancini, Georgina E. Menzies, Claire Morgan, John Wills, George E. Johnson, Paul A. White and Paul D. Lewis.

in Mutagenesis

May 2016; p ublished online July 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 2584 words.

Assessment of genetic toxicity and/or carcinogenic activity is an essential element of chemical screening programs employed to protect human health. Dose–response and gene mutation data are...

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations

John W. Wills, George E. Johnson, Shareen H. Doak, Lya G. Soeteman-Hernández, Wout Slob and Paul A. White.

in Mutagenesis

May 2016; p ublished online December 2015 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Genetics and Genomics. 6412 words.

Genetic toxicity testing has traditionally been used for hazard identification, with dichotomous classification of test results serving to identify genotoxic agents. However, the utility of...

Conserving Phylogenetic Diversity Can Be a Poor Strategy for Conserving Functional Diversity

Florent Mazel, Arne O. Mooers, Giulio Valentino Dalla Riva and Matthew W. Pennell.

in Systematic Biology

November 2017; p ublished online June 2017 .

Journal Article. Subjects: Biological Sciences; Evolutionary Biology; Genetics and Genomics. 6818 words.

Abstract

For decades, academic biologists have advocated for making conservation decisions in light of evolutionary history. Specifically, they suggest that...

Cost benefit analysis of sexually transmitted diseases

Ayşen Bulut.

in FEMS Immunology & Medical Microbiology

July 1999; p ublished online January 2006 .

Journal Article. Subjects: Medical Microbiology and Virology; Biotechnology; Genetics and Genomics; Microbiology; Molecular and Cell Biology. 3790 words.

Abstract

Suggested measures to prevent transmission and sequelae of sexually transmitted diseases are almost universally agreed. But the important question...

R-SAP: a multi-threading computational pipeline for the characterization of high-throughput RNA-sequencing data

Vinay K. Mittal and John F. McDonald.

in Nucleic Acids Research

May 2012; p ublished online January 2012 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7425 words.

The rapid expansion in the quantity and quality of RNA-Seq data requires the development of sophisticated high-performance bioinformatics tools capable of rapidly transforming this data...

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Chloroplast transit peptide prediction: a peek inside the black box

Andrew I. Schein, Jessica C. Kissinger and Lyle H. Ungar.

in Nucleic Acids Research

August 2001; p ublished online August 2001 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4235 words.

Previous work in predicting protein localization to the chloroplast organelle in plants led to the development of an artificial neural network-based approach capable of remarkable accuracy...

Meta-prediction of phosphorylation sites with weighted voting and restricted grid search parameter selection

Ji Wan, Shuli Kang, Chuanning Tang, Jianhua Yan, Yongliang Ren, Jie Liu, Xiaolian Gao, Arindam Banerjee, Lynda B. M. Ellis and Tongbin Li.

in Nucleic Acids Research

March 2008; p ublished online January 2008 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6794 words.

Meta-predictors make predictions by organizing and processing the predictions produced by several other predictors in a defined problem domain. A proficient meta-predictor not only offers...

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Endocrine-disrupting chemicals, epigenetics, and skeletal system dysfunction: exploration of links using bisphenol A as a model system

Frances Xin, Lauren M Smith, Martha Susiarjo, Marisa S Bartolomei and Karl J Jepsen.

Edited by Toshihiro Shioda.

in Environmental Epigenetics

P ublished online April 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 8441 words.

Abstract

Early life exposures to endocrine-disrupting chemicals (EDCs) have been associated with physiological changes of endocrine-sensitive tissues...

FAF-Drugs3: a web server for compound property calculation and chemical library design

David Lagorce, Olivier Sperandio, Jonathan B. Baell, Maria A. Miteva and Bruno O. Villoutreix.

in Nucleic Acids Research

July 2015; p ublished online April 2015 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5155 words.

Drug attrition late in preclinical or clinical development is a serious economic problem in the field of drug discovery. These problems can be linked, in part, to the quality of the...

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