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founder

Overview page. Subjects: Warfare and Defence — Maritime History.

Of a ship, to sink at sea, generally understood to be by the flooding of its hull either through springing a leak or through striking a rock. Other causes of a ship sinking, such as...

See overview in Oxford Index

Genomic deletion induced by Tol2 transposon excision in zebrafish

Peng Huang, Linjie Xu, Wei Liang, Chi Ian Tam, Yutian Zhang, Fei Qi, Zuoyan Zhu, Shuo Lin and Bo Zhang.

in Nucleic Acids Research

January 2013; p ublished online November 2012 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4188 words.

Genomic deletions induced by imprecise excision of transposons have been used to disrupt gene functions in Drosophila. To determine the excision properties of Tol2, a popular transposon in...

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Molecular Haplotyping of Genetic Markers 10 kb Apart by Allele-Specific Long-Range PCR

Sonia Michalatos-Beloin, Sarah A. Tishkoff, Kevin L. Bentley, Kenneth K. Kidd and Gualberto Ruano.

in Nucleic Acids Research

December 1996; p ublished online December 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 1516 words.

Haplotypes, combinations of polymorphic markers in a chromosome, are critical for genome diversity research. However, their utility in population samplings is compromised by uncertain...

Estimation of the RNU2 macrosatellite mutation rate by BRCA1 mutation tracing

Chloé Tessereau, Yann Lesecque, Nastasia Monnet, Monique Buisson, Laure Barjhoux, Mélanie Léoné, Bingjian Feng, David E. Goldgar, Olga M. Sinilnikova, Sylvain Mousset, Laurent Duret and Sylvie Mazoyer.

in Nucleic Acids Research

August 2014; p ublished online July 2014 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6928 words.

Large tandem repeat sequences have been poorly investigated as severe technical limitations and their frequent absence from the genome reference hinder their analysis. Extensive...

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High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases

Zhongwei Qiu, Meizhen Liu, Zhaohua Chen, Yanjiao Shao, Hongjie Pan, Gaigai Wei, Chao Yu, Long Zhang, Xia Li, Ping Wang, Heng-Yu Fan, Bing Du, Bin Liu, Mingyao Liu and Dali Li.

in Nucleic Acids Research

June 2013; p ublished online April 2013 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5330 words.

Transcription activator-like effector nucleases (TALENs) are a powerful new approach for targeted gene disruption in various animal models, but little is known about their activities in Mus...

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Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana

Thierry Pélissier, Cécile Bousquet-Antonelli, Laurence Lavie and Jean-Marc Deragon.

in Nucleic Acids Research

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8394 words.

Despite the ubiquitous distribution of tRNA-related short interspersed elements (SINEs) in eukaryotic species, very little is known about the synthesis and processing of their RNAs. In this...

A novel UV-damaged DNA binding protein emerges during the chromatin-eliminating cleavage period in Ascaris suum

Christof Seidl and Karl B. Moritz.

in Nucleic Acids Research

February 1998; p ublished online February 1998 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6944 words.

During the early cleavage period of Ascaris suum, chromatin diminution takes place in the somatic founder cells. In the process of chromatin diminution numerous heterochromatic blocks,...

Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene

Timothy A. Graubert, Bruce A. Hug, Robin Wesselschmidt, Chih-Lin Hsieh, Thomas M. Ryan, Tim M. Townes and Timothy J. Ley.

in Nucleic Acids Research

June 1998; p ublished online June 1998 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6034 words.

The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause...

Helix–hairpin–helix protein MJ1434 from Methanocaldococcus jannaschii and EndoIV homologue TTC0482 from Thermus thermophilus HB27 do not process DNA uracil residues

Lars Schomacher, Sabine Smolorz, Elena Ciirdaeva, Svetlana Ber, Wilfried Kramer and Hans-Joachim Fritz.

in Nucleic Acids Research

August 2010; p ublished online April 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6536 words.

The mutagenic threat of hydrolytic DNA cytosine deamination is met mostly by uracil DNA glycosylases (UDG) initiating base excision repair. However, several sequenced genomes of archaeal...

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Families of restriction enzymes: an analysis prompted by molecular and genetic data for type ID restriction and modification systems

Annette J. B. Titheradge, Jonathan King, Junichi Ryu and Noreen E. Murray.

in Nucleic Acids Research

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9208 words.

Current genetic and molecular evidence places all the known type I restriction and modification systems of Escherichia coli and Salmonella enterica into one of four discrete families: type...

Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene

Chiaki Ohtaka-Maruyama, Xiaoyan Wang, Hong Ge and Ana B. Chepelinsky.

in Nucleic Acids Research

January 1998; p ublished online January 1998 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5072 words.

The MIP gene, the founder of the MIP family of channel proteins, is specifically expressed in fiber cells of the ocular lens and expression is regulated temporally and spatially during...

Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass

Heather Ordonez and Stewart Shuman.

in Nucleic Acids Research

November 2014; p ublished online October 2014 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8330 words.

Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the...

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Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation

Heather Ordonez, Maria Loressa Uson and Stewart Shuman.

in Nucleic Acids Research

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9750 words.

This study unveils Mycobacterium smegmatis DinB2 as the founder of a clade of Y-family DNA polymerase that is naturally adept at incorporating ribonucleotides by virtue of a leucine in lieu...

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