founder
Overview page. Subjects: Warfare and Defence — Maritime History.
Of a ship, to sink at sea, generally understood to be by the flooding of its hull either through springing a leak or through striking a rock. Other causes of a ship sinking, such as...
Genomic deletion induced by Tol2 transposon excision in zebrafish
in Nucleic Acids Research
January 2013; p ublished online November 2012 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4188 words.
Genomic deletions induced by imprecise excision of transposons have been used to disrupt gene functions in Drosophila. To determine the excision properties of Tol2, a popular transposon in...
Go to » full text: open access
Molecular Haplotyping of Genetic Markers 10 kb Apart by Allele-Specific Long-Range PCR
in Nucleic Acids Research
December 1996; p ublished online December 1996 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 1516 words.
Haplotypes, combinations of polymorphic markers in a chromosome, are critical for genome diversity research. However, their utility in population samplings is compromised by uncertain...
Estimation of the RNU2 macrosatellite mutation rate by BRCA1 mutation tracing
in Nucleic Acids Research
August 2014; p ublished online July 2014 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6928 words.
Large tandem repeat sequences have been poorly investigated as severe technical limitations and their frequent absence from the genome reference hinder their analysis. Extensive...
Go to » full text: open access
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases
in Nucleic Acids Research
June 2013; p ublished online April 2013 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5330 words.
Transcription activator-like effector nucleases (TALENs) are a powerful new approach for targeted gene disruption in various animal models, but little is known about their activities in Mus...
Go to » full text: open access
Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana
in Nucleic Acids Research
January 2004; p ublished online January 2004 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8394 words.
Despite the ubiquitous distribution of tRNA-related short interspersed elements (SINEs) in eukaryotic species, very little is known about the synthesis and processing of their RNAs. In this...
A novel UV-damaged DNA binding protein emerges during the chromatin-eliminating cleavage period in Ascaris suum
in Nucleic Acids Research
February 1998; p ublished online February 1998 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6944 words.
During the early cleavage period of Ascaris suum, chromatin diminution takes place in the somatic founder cells. In the process of chromatin diminution numerous heterochromatic blocks,...
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene
in Nucleic Acids Research
June 1998; p ublished online June 1998 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6034 words.
The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause...
Helix–hairpin–helix protein MJ1434 from Methanocaldococcus jannaschii and EndoIV homologue TTC0482 from Thermus thermophilus HB27 do not process DNA uracil residues
in Nucleic Acids Research
August 2010; p ublished online April 2010 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6536 words.
The mutagenic threat of hydrolytic DNA cytosine deamination is met mostly by uracil DNA glycosylases (UDG) initiating base excision repair. However, several sequenced genomes of archaeal...
Go to » full text: open access
Families of restriction enzymes: an analysis prompted by molecular and genetic data for type ID restriction and modification systems
in Nucleic Acids Research
October 2001; p ublished online October 2001 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9208 words.
Current genetic and molecular evidence places all the known type I restriction and modification systems of Escherichia coli and Salmonella enterica into one of four discrete families: type...
Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene
in Nucleic Acids Research
January 1998; p ublished online January 1998 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5072 words.
The MIP gene, the founder of the MIP family of channel proteins, is specifically expressed in fiber cells of the ocular lens and expression is regulated temporally and spatially during...
Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass
in Nucleic Acids Research
November 2014; p ublished online October 2014 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8330 words.
Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the...
Go to » full text: open access
Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation
in Nucleic Acids Research
September 2014; p ublished online September 2014 .
Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9750 words.
This study unveils Mycobacterium smegmatis DinB2 as the founder of a clade of Y-family DNA polymerase that is naturally adept at incorporating ribonucleotides by virtue of a leucine in lieu...
Go to » full text: open access
