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fusion

Overview page. Subjects: Medicine and Health.

n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...

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Polyionic fusion peptides function as specific dimerization motifs

Susanne A. Richter, Kay Stubenrauch, Hauke Lilie and Rainer Rudolph.

in Protein Engineering, Design and Selection

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Proteins. 7104 words.

The de novo design of a molecular adapter for directed association and covalent linkage of two polypeptides is presented. Using peptides containing charged amino acid residues and an...

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Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo

Min Wei, Jose Marino, Aaron Trowell, Huiping Zhang, Jaclyn Stromp Peraino, Priyani V. Rajasekera, Joren C. Madsen, David H. Sachs, Christene A. Huang, Gilles Benichou and Zhirui Wang.

in Protein Engineering, Design and Selection

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Proteins. 3763 words.

Regulatory T cells (Tregs) are a subpopulation of CD4+ T cells which suppress immune responses of effector cells and are known to play a very important role in protection against autoimmune...

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A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody–ribonuclease fusion protein targeting the EGF receptor

Stefan Kiesgen, Nora Liebers, Martin Cremer, Ulrich Arnold, Tobias Weber, Armin Keller, Christel Herold-Mende, Gerhard Dyckhoff, Dirk Jäger, Roland E. Kontermann, Michaela A. E. Arndt and Jürgen Krauss.

in Protein Engineering, Design and Selection

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Proteins. 4025 words.

Due to its frequent overexpression in a variety of solid tumors the epidermal growth factor receptor (EGFR) is a well-established target for therapeutic interventions in epithelial cancers....

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Bioactive IL7-diphtheria fusion toxin secreted by mammalian cells

S. Shulga-Morskoy and B.E. Rich.

in Protein Engineering, Design and Selection

January 2005; p ublished online March 2005 .

Journal Article. Subjects: Proteins. 4896 words.

A number of targeted cytotoxic agents have been developed that selectively kill malignant or otherwise pathological cells. These engineered proteins consist of a potent cytotoxic element...

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Functional EGFP–dystrophin fusion proteins for gene therapy vector development

Pierre Chapdelaine, Pierre-Alain Moisset, Philippe Campeau, Isabelle Asselin, Jean-Thomas Vilquin and Jacques P. Tremblay.

in Protein Engineering, Design and Selection

September 2000; p ublished online September 2000 .

Journal Article. Subjects: Proteins. 2906 words.

Transfection and transduction studies involving the use of the full-length dystrophin (11 kb) or the truncated mini-gene (6 kb) cDNAs are hampered by the large size of the resulting viral...

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LINKER: a program to generate linker sequences for fusion proteins

Chiquito J. Crasto and Jin-an Feng.

in Protein Engineering, Design and Selection

May 2000; p ublished online May 2000 .

Journal Article. Subjects: Proteins. 2568 words.

The construction of functional fusion proteins often requires a linker sequence that adopts an extended conformation to allow for maximal flexibility. Linker sequences are generally...

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Improved cytotoxicity of novel TRAIL variants produced as recombinant fusion proteins

Małgorzata Figiel, Piotr Bonarek, Andrzej Górecki, Sebastian D Pawlak, Bartłomiej Żerek, Beata Chęcińska, Jerzy Pieczykolan and Marta Dziedzicka-Wasylewska.

in Protein Engineering, Design and Selection

February 2018; p ublished online January 2018 .

Journal Article. Subjects: Proteins. 6717 words.

Abstract

The TNF-Related Apoptosis Inducing Ligand (TRAIL) cytokine triggers apoptosis specifically in cancer cells. Susceptibility of a given cell to TRAIL...

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Landscape phages and their fusion proteins targeted to breast cancer cells

Olusegun A. Fagbohun, Deepa Bedi, Natalia I. Grabchenko, Patricia A. Deinnocentes, Richard C. Bird and Valery A. Petrenko.

in Protein Engineering, Design and Selection

June 2012; p ublished online April 2012 .

Journal Article. Subjects: Proteins. 7593 words.

Breast cancer is a leading cause of death among women in the USA. The efficacy of existing anticancer therapeutics can be improved by targeting them through conjugation with ligands binding...

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Selection for intrabody solubility in mammalian cells using GFP fusions

Laurence Guglielmi, Vincent Denis, Nadia Vezzio-Vié, Nicole Bec, Piona Dariavach, Christian Larroque and Pierre Martineau.

in Protein Engineering, Design and Selection

December 2011; p ublished online October 2011 .

Journal Article. Subjects: Proteins. 6464 words.

Single-chain antibody fragments (scFv) expressed in the cytoplasm of mammalian cells, also called intrabodies, have many applications in functional proteomics. These applications are,...

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Functional expression of adhesive peptides as fusions to Escherichia coli flagellin.

B Westerlund-Wikström, J Tanskanen, R Virkola, J Hacker, M Lindberg, M Skurnik and T K Korhonen.

in Protein Engineering, Design and Selection

November 1997; p ublished online November 1997 .

Journal Article. Subjects: Proteins. 0 words.

An expression system for studying epitopes of adhesion proteins based on fusion of gene fragments into fliC(H7) of Escherichia coli is described. We constructed the system by an in-frame...

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Precise and efficient cleavage of recombinant fusion proteins using mammalian aspartic proteases

Blanka Kühnel, Joenel Alcantara, Joseph Boothe, Gijs van Rooijen and Maurice Moloney.

in Protein Engineering, Design and Selection

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Proteins. 4541 words.

Expression of recombinant proteins as translational fusions is commonly employed to enhance stability, increase solubility and facilitate purification of the desired protein. In general,...

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A minichaperone-based fusion system for producing insoluble proteins in soluble stable forms

Olga A. Sharapova, Maria S. Yurkova and Alexey N. Fedorov.

in Protein Engineering, Design and Selection

February 2016; p ublished online November 2015 .

Journal Article. Subjects: Proteins. 5782 words.

We have developed a fusion system for reliable production of insoluble hydrophobic proteins in soluble stable forms. A carrier is thermophilic minichaperone, GroEL apical domain (GrAD), a...

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High level expression and secretion of Fc-X fusion proteins in mammalian cells.

K M Lo, Y Sudo, J Chen, Y Li, Y Lan, S M Kong, L Chen, Q An and S D Gillies.

in Protein Engineering, Design and Selection

June 1998; p ublished online June 1998 .

Journal Article. Subjects: Proteins. 0 words.

We have developed a general expression system that enhances the production and secretion of proteins in mammalian cells. The protein of interest is expressed as a fusion to a signal peptide...

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Cancer cell-specific internalizing ligands from phage displayed β-lactamase-peptide fusion libraries

Girja S. Shukla and David N. Krag.

in Protein Engineering, Design and Selection

June 2010; p ublished online March 2010 .

Journal Article. Subjects: Proteins. 7295 words.

The present study was focused on identifying cancer cell-specific internalizing ligands using a new kind of phage display library in which the linear or cysteine-constrained random peptides...

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Properties of 7ND–CCL2 are modulated upon fusion to Fc

India C. Severin, Adriano L.S. Souza, Jonathan H. Davis, Najia Musolino, Matthias Mack, Christine A. Power and Amanda E.I. Proudfoot.

in Protein Engineering, Design and Selection

May 2012; p ublished online March 2012 .

Journal Article. Subjects: Proteins. 6739 words.

7ND, a truncated version of the chemokine MCP-1/CCL2 lacking amino acids 2–8, is a potent antagonist of CCR2. In contrast to CCL2, 7ND is an obligate monomer. Similar to other chemokines,...

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Characterization of a ricin fusion toxin targeted to the interleukin-2 receptor

Arthur E. Frankel, Chris Burbage, Tao Fu, Edward Tagge, John Chandler and Mark Willingham.

in Protein Engineering, Design and Selection

October 1996 .

Journal Article. Subjects: Proteins. 0 words.

Fusion toxins are hybrid proteins consisting of peptide ligands linked through amide bonds to polypeptide toxins. The ligand directs the molecule to the surface of target cells and the...

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Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor

Arthur E. Frankel, Jason Ramage, Melanie Kiser, Richard Alexander, Gregory Kucera and Mark Steven Miller.

in Protein Engineering, Design and Selection

August 2000; p ublished online August 2000 .

Journal Article. Subjects: Proteins. 5029 words.

Diphtheria fusion proteins are chimeric proteins consisting of the catalytic and translocation domains of diphtheria toxin (DT388) linked through an amide bond to one of a variety of...

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Modelling the structure of the fusion protein from human respiratory syncytial virus

Brian J. Smith, Michael C. Lawrence and Peter M. Colman.

in Protein Engineering, Design and Selection

May 2002; p ublished online May 2002 .

Journal Article. Subjects: Proteins. 4249 words.

The fusion protein of respiratory syncytial virus (RSV-F) is responsible for fusion of virion with host cells and infection of neighbouring cells through the formation of syncytia. A...

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A novel dual-cytokine–antibody fusion protein for the treatment of CD38-positive malignancies

Roberto De Luca, Paul Kachel, Klara Kropivsek, Berend Snijder, Markus G Manz and Dario Neri.

in Protein Engineering, Design and Selection

May 2018; p ublished online July 2018 .

Journal Article. Subjects: Proteins. 4096 words.

Abstract

A novel dual-cytokine–antibody fusion protein, consisting of an antibody directed against CD38 [a tumor-associated antigen mainly expressed on the...

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A TAT–streptavidin fusion protein directs uptake of biotinylated cargo into mammalian cells

Brian Albarran, Richard To and Patrick S. Stayton.

in Protein Engineering, Design and Selection

March 2005; p ublished online April 2005 .

Journal Article. Subjects: Proteins. 3566 words.

The HIV-1 TAT peptide has been used extensively for directing the intracellular delivery of an assortment of cargo, including DNA, liposomes and macromolecules. For protein delivery, a...

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