Oxford Index Search Results

You are looking at 1-20 of 356 items for:

fusion x Medical Oncology x clear all

fusion

Overview page. Subjects: Medicine and Health.

n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...

See overview in Oxford Index

Resistance to enfuvirtide, the first HIV fusion inhibitor

Michael L. Greenberg and Nick Cammack.

in Journal of Antimicrobial Chemotherapy

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6849 words.

Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human immunodeficiency virus infection. Enfuvirtide is the first in this class to reach market approval....

Go to Oxford Journals »  abstract

PDTM-40. PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER.

Payal Jain, Tamara Fierst, Harry Han, Tiffany Smith, Phillip B Storm, Angela J Waanders and Adam C Resnick.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Pediatric low-grade gliomas (PLGGs) are the most common brain tumors in children mainly defined by activating gene fusions that dysregulate the...

Go to Oxford Journals »  home page

Pulmonary Inflammatory Myofibroblastic Tumor Harboring EML4-ALK Fusion Gene

Akihiko Sokai, Makiko Enaka, Risa Sokai, Shoichi Mori, Shunsuke Mori, Masaharu Gunji, Masahiko Fujino and Masafumi Ito.

in Japanese Journal of Clinical Oncology

January 2014; p ublished online November 2013 .

Journal Article. Subjects: Medical Oncology. 1579 words.

Inflammatory myofibroblastic tumor is a rare tumor deriving from mesenchymal tissue. Approximately 50% of inflammatory myofibroblastic tumors harbor an anaplastic lymphoma kinase fusion...

Go to Oxford Journals »  abstract

Clinical perspective of fusion inhibitors for treatment of HIV

J. K. Rockstroh and S. Mauss.

in Journal of Antimicrobial Chemotherapy

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2249 words.

The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options...

Go to Oxford Journals »  abstract

TMOD-29. DEVELOPMENT OF PRECLINICAL GLIOMA MOUSE MODELS FOR GENE FUSIONS

Barbara Oldrini, Carolina Marques and Massimo Squatrito.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

The occurrence and importance of gene fusions in glioma has been appreciated only recently, largely due to high throughput technologies, and gene...

Go to Oxford Journals »  home page

ROS1 fusions in Chinese patients with non-small-cell lung cancer

W. Cai, X. Li, C. Su, L. Fan, L. Zheng, K. Fei, C. Zhou, C. Manegold and G. Schmid-Bindert.

in Annals of Oncology

July 2013; p ublished online March 2013 .

Journal Article. Subjects: Medical Oncology. 3688 words.

Background

To determine the prevalence and clinicopathological features of ROS1 fusions in Chinese patients with non-small-cell lung cancer (NSCLC).

null...

Go to Oxford Journals »  abstract

Pioglitazone Therapy of PAX8-PPARγ Fusion Protein Thyroid Carcinoma

Thomas J Giordano, Bryan R Haugen, Steven I Sherman, Manisha H Shah, Elaine M Caoili and Ronald J Koenig.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 2472 words.

Abstract

Context

A subset of thyroid carcinomas expresses an oncogenic paired box 8 (PAX8) and peroxisome...

Go to Oxford Journals »  home page

O2.06USE OF MRI FUSION FOR CT BASED INTRACRANIAL STEREOTACTIC RADIOSURGERY

H.B. Caglar, A. Yildirim Altinok, E. Kucukmorkoc, H. Acar and N. Kucuk.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

The aim of this study is to evaluate the reliability of MRI fusion when determining intracranial target volume when performing CT based intracranial stereotactic radiosurgery. Patients...

Go to Oxford Journals »  abstract

P05.02KIAA1549:BRAF FUSION GENE IN PEDIATRIC BRAIN TUMORS OF VARIOUS HISTOGENESIS

C. Baldi, M. Antonelli, M. Badiali, F.R. Buttarelli, L. Moi, P. Nozza, A. Arcella, M. Massimino, M. Sanson and F. Giangaspero.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Pediatric GBMs (pGBM) are histologically indistinguishable from adult GBM (aGBM) however they are molecularly distinct. Few molecular data exists on the mechanism underlying...

Go to Oxford Journals »  abstract

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer

R J Hartmaier, S E Trabucco, N Priedigkeit, J H Chung, C A Parachoniak, P Vanden Borre, S Morley, M Rosenzweig, L M Gay, M E Goldberg, J Suh, S M Ali, J Ross, B Leyland-Jones, B Young, C Williams, B Park, M Tsai, B Haley, J Peguero, R D Callahan, I Sachelarie, J Cho, J M Atkinson, A Bahreini, A M Nagle, S L Puhalla, R J Watters, Z Erdogan-Yildirim, L Cao, S Oesterreich, A Mathew, P C Lucas, N E Davidson, A M Brufsky, G M Frampton, P J Stephens, J Chmielecki and A V Lee.

in Annals of Oncology

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Medical Oncology. 4005 words.

Abstract

Background

Estrogen receptor-positive (ER-positive) metastatic breast cancer is often intractable due to...

Go to Oxford Journals »  home page

Specific Occlusion of Murine and Human Tumor Vasculature by VCAM-1–Targeted Recombinant Fusion Proteins

Ariane Dienst, Andrea Grunow, Maike Unruh, Berit Rabausch, Jacques E. Nör, Jochen W. U. Fries and Claudia Gottstein.

in JNCI: Journal of the National Cancer Institute

May 2005; p ublished online May 2005 .

Journal Article. Subjects: Medical Oncology. 12282 words.

Background: The tumor vasculature is increasingly recognized as a target for cancer therapy. We developed and evaluated recombinant fusion proteins targeting the...

Go to Oxford Journals »  home page

Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor

Christopher Cianci, Nicholas Meanwell and Mark Krystal.

in Journal of Antimicrobial Chemotherapy

March 2005; p ublished online March 2005 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2848 words.

BMS-433771 is an orally bioavailable respiratory syncytial virus (RSV) inhibitor, functioning through inhibition of viral F protein-induced membrane fusion. The compound is active against...

Go to Oxford Journals »  abstract

Impact of a New Fusion Receptor on PD-1–Mediated Immunosuppression in Adoptive T Cell Therapy

Sebastian Kobold, Simon Grassmann, Michael Chaloupka, Christopher Lampert, Susanne Wenk, Fabian Kraus, Moritz Rapp, Peter Düwell, Yi Zeng, Jan C. Schmollinger, Max Schnurr, Stefan Endres and Simon Rothenfußer.

in JNCI: Journal of the National Cancer Institute

P ublished online June 2015 .

Journal Article. Subjects: Medical Oncology. 6131 words.

Background:

Adoptive T cell transfer (ACT) is currently under investigation for the treatment of metastatic cancer. Recent evidence suggests that the...

Go to Oxford Journals »  home page

Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas

Kirsi J Granberg, Matti Annala, Birgitta Lehtinen, Juha Kesseli, Joonas Haapasalo, Pekka Ruusuvuori, Olli Yli-Harja, Tapio Visakorpi, Hannu Haapasalo, Matti Nykter and Wei Zhang.

in Neuro-Oncology

September 2017; p ublished online April 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 5757 words.

Abstract

Background

Inhibitors of fibroblast growth factor receptors (FGFRs) have recently arisen as a promising...

Go to Oxford Journals »  home page

Concatenated Multitype L2 Fusion Proteins as Candidate Prophylactic Pan-Human Papillomavirus Vaccines

Subhashini Jagu, Balasubramanyam Karanam, Ratish Gambhira, Sudha V. Chivukula, Revathi J. Chaganti, Douglas R. Lowy, John T. Schiller and Richard B. S. Roden.

in JNCI: Journal of the National Cancer Institute

June 2009; p ublished online June 2009 .

Journal Article. Subjects: Medical Oncology. 7416 words.

Background

Vaccination with minor capsid protein L2 induces antibodies that cross-neutralize diverse papillomavirus types. However, neutralizing antibody...

Go to Oxford Journals »  full text: open access   » abstract

GENE-44. CHROMOTHRIPSIS LEADS TO CHROMOSOMAL REARRANGEMENTS AND GENE FUSIONS IN PRIMARY GLIOBLASTOMAS

Audrey Rousseau, Anne Coutolleau, Philippe Menei, Philippe Guardiola and Blandine Boisselier.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Glioblastoma (GB) is the most frequent and lethal form of diffuse glioma. GB displays...

Go to Oxford Journals »  home page

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected

F Pietrantonio, F Di Nicolantonio, A B Schrock, J Lee, F Morano, G Fucà, P Nikolinakos, A Drilon, J F Hechtman, J Christiansen, K Gowen, G M Frampton, P Gasparini, D Rossini, C Gigliotti, S T Kim, M Prisciandaro, J Hodgson, A Zaniboni, V K Chiu, M Milione, R Patel, V Miller, A Bardelli, L Novara, L Wang, S M Pupa, G Sozzi, J Ross, M Di Bartolomeo, A Bertotti, S Ali, L Trusolino, A Falcone, F de Braud and C Cremolini.

in Annals of Oncology

June 2018; p ublished online March 2018 .

Journal Article. Subjects: Medical Oncology. 2850 words.

Abstract

Background

Recognition of rare molecular subgroups is a challenge for precision oncology and may lead to...

Go to Oxford Journals »  home page

EPEN-19. SUPRATENTORIAL EPENDYMOMAS - L1CAM EXPRESSION AND RELA FUSION, THEIR CORRELATION WITH CLINICOPATHOLOGICAL FEATURES

Gouri Anvekar, Mamta Gurav, Omshree Shetty, Vinayak Kadam, Ayushi Sahay, Girish Chinnaswamy, Prakash Shetty, Aliasgar Moiyadi, Tejpal Gupta, Rakesh Jalali and Sridhar Epari.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

This study was undertaken to evaluate the frequency of RELA fusion 1/2 in supratentorial...

Go to Oxford Journals »  home page

Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza

Hong Zhang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online January 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 3644 words.

Sialidase fusion protein is reported to have great potential to combat seasonal and pandemic influenza, because it may prevent influenza virus infection by removing all sialic acid...

Go to Oxford Journals »  abstract

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure

Marcelo T. Augusto, Axel Hollmann, Miguel A. R. B. Castanho, Matteo Porotto, Antonello Pessi and Nuno C. Santos.

in Journal of Antimicrobial Chemotherapy

May 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7143 words.

Objectives

The aim of the present work was to evaluate the interaction of two new HIV fusion inhibitors {HIVP3 [C34–polyethylene glycol (PEG)4–cholesterol]...

Go to Oxford Journals »  abstract