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fusion

Overview page. Subjects: Medicine and Health.

n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...

See overview in Oxford Index

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen and Roland C Grafström.

in Toxicological Sciences

March 2018; p ublished online November 2017 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7659 words.

Abstract

Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and...

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The Mixture of “Ecstasy” and Its Metabolites Impairs Mitochondrial Fusion/Fission Equilibrium and Trafficking in Hippocampal Neurons, at In Vivo Relevant Concentrations

Daniel José Barbosa, Romàn Serrat, Serena Mirra, Martí Quevedo, Elena Goméz de Barreda, Jesús Àvila, Luísa Maria Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Eduardo Soriano and Félix Carvalho.

in Toxicological Sciences

June 2014; p ublished online March 2014 .

Journal Article. Subjects: Toxicology (Non-medical). 8060 words.

3,4-Methylenedioxymethamphetamine (MDMA; “ecstasy”) is a potentially neurotoxic recreational drug of abuse. Though the mechanisms involved are still not completely understood, formation of...

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Method Comparison of the Ortho Vitros Fusion 5,1 Chemistry Analyzer and the Roche COBAS Integra 400 for Urine Drug Screen Testing in the Emergency Department

Kamisha L. Johnson-Davis, Catherine D. Thompson, Chantry J. Clark, Gwen A. McMillin and Christopher M. Lehman.

in Journal of Analytical Toxicology

June 2012; p ublished online June 2012 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 3062 words.

Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid...

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A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents

Jeffrey L. Larson, Seong-Kwi Kang, Bo In Choi, Maria Hedlund, Laura M. Aschenbrenner, Beth Cecil, GloriaMay Machado, Matthew Nieder and Fang Fang.

in Toxicological Sciences

August 2011; p ublished online May 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8631 words.

DAS181 is a novel inhaled drug candidate blocking influenza virus (IFV) and parainfluenza virus (PIV) infections through removal of sialic acid receptors from epithelial surface of the...

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High Amphetamine/Methamphetamine Concentrations in Urine Can Cause Error Codes on the Ortho Vitros® Fusion 5,1 FS Automated Chemistry Analyzer

Kamisha L. Johnson-Davis, Catherine D. Thompson, Chantry J. Clark, Gwendolyn A. McMillin and Christopher M. Lehman.

in Journal of Analytical Toxicology

November 2010; p ublished online November 2010 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

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Immunogenicity, Inflammation, and Lipid Accumulation in Cynomolgus Monkeys Infused with a Lipidated Tetranectin-ApoA-I Fusion Protein

Franziska Regenass-Lechner, Roland F. Staack, Jean-Luc Mary, Wolfgang F. Richter, Michael Winter, Gregor Jordan, Nicole Justies, Anja Langenkamp, Rosario Garrido, Mudher Albassam, Thomas Singer and Elke-Astrid Atzpodien.

in Toxicological Sciences

April 2016; p ublished online January 2016 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6503 words.

High density lipoprotein (HDL)-targeted therapies, which promote cholesterol efflux from cells, are currently in development for reducing cardiovascular events in acute coronary syndrome....

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Differential Binding Affinities of PCBs, HO-PCBs, and Aroclors with Recombinant Human, Rainbow Trout (Onchorhynkiss mykiss), and Green Anole (Anolis carolinensis) Estrogen Receptors, Using a Semi-High Throughput Competitive Binding Assay

Jason Matthews and Tim Zacharewski.

in Toxicological Sciences

February 2000; p ublished online February 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 10471 words.

A comparative study was undertaken to assess the ability of 44 polychlorinated biphenyls (PCBs), 9 hydroxylated PCBs (HO-PCBs), and 8 aroclors at concentrations ranging from 1 nM to 10 μM...

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Suppression of Autophagic Flux by Bile Acids in Hepatocytes

Sharon Manley, Hong-Min Ni, Bo Kong, Udayan Apte, Grace Guo and Wen-Xing Ding.

in Toxicological Sciences

February 2014; p ublished online November 2013 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6708 words.

Retention of bile acids (BAs) in the liver during cholestasis plays an important role in the development of cholestatic liver injury. Several studies have reported that high concentrations...

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Adding Insult to Injury: Effects of Xenobiotic-Induced Preantral Ovotoxicity on Ovarian Development and Oocyte Fusibility

Alexander P. Sobinoff, Victoria Pye, Brett Nixon, Shaun D. Roman and Eileen A. McLaughlin.

in Toxicological Sciences

December 2010; p ublished online September 2010 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7800 words.

Mammalian females are born with a finite number of nonrenewing primordial follicles, the majority of which remain in a quiescent state for many years. Because of their nonrenewing nature,...

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From the Cover: Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells

Vasundhra Bahl, Kimberly Johnson, Rattapol Phandthong, Atena Zahedi, Suzaynn F. Schick and Prue Talbot.

in Toxicological Sciences

September 2016; p ublished online June 2016 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9173 words.

Thirdhand cigarette smoke (THS) was recently recognized as an environmental health hazard; however, little is known about it effects on cells. Mitochondria are sensitive monitors of cell...

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Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Developmental Defects in the Rat Vagina

Mary K. Dienhart, Rebecca J. Sommer, Richard E. Peterson, Anne N. Hirshfield and Ellen K. Silbergeld.

in Toxicological Sciences

July 2000; p ublished online July 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5620 words.

At puberty, female rats exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exhibit a persistent thread of mesenchymal tissue surrounded by keratinized epithelium that partially...

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Relationship between Embryonic Histonic Hyperacetylation and Axial Skeletal Defects in Mouse Exposed to the Three HDAC Inhibitors Apicidin, MS-275, and Sodium Butyrate

Francesca Di Renzo, Maria Luisa Broccia, Erminio Giavini and Elena Menegola.

in Toxicological Sciences

August 2007; p ublished online May 2007 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 3698 words.

Some histone deacetylase inhibitors (HDACi) have recently been related to teratogenic effects in rodents. Skeletal defects have been directly associated with embryonic hyperacetylation of...

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Antiandrogenic Effects of Bisphenol A and Nonylphenol on the Function of Androgen Receptor

Hyun Ju Lee, Soma Chattopadhyay, Eun-Yeung Gong, Ryun Sup Ahn and Keesook Lee.

in Toxicological Sciences

September 2003; p ublished online September 2003 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5031 words.

By using a yeast detection system for androgenic and antiandrogenic effects of chemicals, we identified bisphenol A (BPA) and nonylphenol (NP) as antiandrogens. In this study, we report...

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Nonclinical Safety, Pharmacokinetics, and Pharmacodynamics of Atacicept

Michela Carbonatto, Ping Yu, Mauro Bertolino, Enrico Vigna, Stephanie Steidler, Laura Fava, Chiara Daghero, Bruno Roattino, Manuela Onidi, Michele Ardizzone, Sergio Peano, Jennifer Visich, Derek Janszen, Stacey Dillon and Rafael Ponce.

in Toxicological Sciences

September 2008; p ublished online June 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8187 words.

Atacicept, a soluble recombinant fusion protein of the human immunoglobulin (Ig) G1 Fc and the extracellular domain of the human transmembrane activator and calcium modulator and...

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The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

Giel Hendriks, Mirna Atallah, Bruno Morolli, Fabienne Calléja, Nienke Ras-Verloop, Ilse Huijskens, Martine Raamsman, Bob van de Water and Harry Vrieling.

in Toxicological Sciences

January 2012; p ublished online October 2011 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7801 words.

People are exposed to an ever-increasing number of chemical compounds that are developed by industry for a wide range of applications. These compounds may harmfully react with different...

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Oxidative Stress Induces Parallel Autophagy and Mitochondria Dysfunction in Human Glioma U251 Cells

Hongyu Zhang, Xiaoxia Kong, Jinsong Kang, Jing Su, Yang Li, Jiateng Zhong and Liankun Sun.

in Toxicological Sciences

August 2009; p ublished online May 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7691 words.

Accumulation of reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) is an oxidative stress response, which induced various defense mechanisms or programmed cell death (PCD). As...

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Chemoinformatics Profiling of Ionic Liquids—Automatic and Chemically Interpretable Cytotoxicity Profiling, Virtual Screening, and Cytotoxicophore Identification

Maykel Cruz-Monteagudo, Evys Ancede-Gallardo, Miguel Jorge and Maria Natália Dias Soeiro Cordeiro.

in Toxicological Sciences

December 2013; p ublished online September 2013 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 14087 words.

Ionic liquids (ILs) possess a unique physicochemical profile providing a wide range of applications. Their almost limitless structural possibilities allow the design of task-specific ILs....

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Mitochondrial Toxicity

Joel N Meyer, Jessica H Hartman and Danielle F Mello.

in Toxicological Sciences

March 2018; p ublished online January 2018 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6941 words.

Abstract

Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many...

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Evaluation of in Vitro Reporter Gene Induction Assays for Use in a Rapid Prescreen for Compound Selection to Test Specificity in the Tg.AC Mouse Short-Term Carcinogenicity Assay

Karol L. Thompson, Barry A. Rosenzweig, Yi Tsong and Frank D. Sistare.

in Toxicological Sciences

September 2000; p ublished online September 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8784 words.

Under ICH guidelines, short-term carcinogenicity assays such as the Tg.AC assay are allowed alternatives for one species in the 2-year rodent bioassay. The Tg.AC transgenic mouse, which...

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Reduced 293T Cell Susceptibility to Acrolein Due to Aldose Reductase–like-1 Protein Expression

Xuyu Zu, Ruilan Yan, Sarah Robbins, Paulette A. Krishack, Duan-Fang Liao and Deliang Cao.

in Toxicological Sciences

June 2007; p ublished online February 2007 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4406 words.

Acrolein is a highly reactive α,β-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living environments, posing serious threats...

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