fusion
Overview page. Subjects: Medicine and Health.
n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...
Resistance to enfuvirtide, the first HIV fusion inhibitor
in Journal of Antimicrobial Chemotherapy
August 2004; p ublished online August 2004 .
Journal Article. Subjects: Medical Oncology; Critical Care. 6849 words.
Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human immunodeficiency virus infection. Enfuvirtide is the first in this class to reach market approval....
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Clinical perspective of fusion inhibitors for treatment of HIV
in Journal of Antimicrobial Chemotherapy
May 2004; p ublished online May 2004 .
Journal Article. Subjects: Medical Oncology; Critical Care. 2249 words.
The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options...
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Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor
in Journal of Antimicrobial Chemotherapy
March 2005; p ublished online March 2005 .
Journal Article. Subjects: Medical Oncology; Critical Care. 2848 words.
BMS-433771 is an orally bioavailable respiratory syncytial virus (RSV) inhibitor, functioning through inhibition of viral F protein-induced membrane fusion. The compound is active against...
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Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza
in Journal of Antimicrobial Chemotherapy
August 2008; p ublished online January 2008 .
Journal Article. Subjects: Medical Oncology; Critical Care. 3644 words.
Sialidase fusion protein is reported to have great potential to combat seasonal and pandemic influenza, because it may prevent influenza virus infection by removing all sialic acid...
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Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure
in Journal of Antimicrobial Chemotherapy
May 2014; p ublished online January 2014 .
Journal Article. Subjects: Medical Oncology; Critical Care. 7143 words.
Objectives
The aim of the present work was to evaluate the interaction of two new HIV fusion inhibitors {HIVP3 [C34–polyethylene glycol (PEG)4–cholesterol]...
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Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181
in Journal of Antimicrobial Chemotherapy
January 2011; p ublished online November 2010 .
Journal Article. Subjects: Medical Oncology; Critical Care. 7713 words.
Background
Influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of...
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The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance
in Journal of Antimicrobial Chemotherapy
October 2014; p ublished online June 2014 .
Journal Article. Subjects: Medical Oncology; Critical Care. 6185 words.
Objectives
Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 are potent fusion inhibitors. We have recently demonstrated that the unique...
Viral receptor blockage by multivalent recombinant antibody fusion proteins: inhibiting human rhinovirus (HRV) infection with CFY196
in Journal of Antimicrobial Chemotherapy
January 2004; p ublished online January 2004 .
Journal Article. Subjects: Medical Oncology; Critical Care. 2236 words.
Viral receptor blockage by monoclonal antibodies (mAbs) is a common strategy to inhibit viral infection; however, no drug candidate acting by this mechanism has reached the market so far....
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Molecular cloning and functional characterization of two novel membrane fusion proteins in conferring antimicrobial resistance in Acinetobacter baumannii
in Journal of Antimicrobial Chemotherapy
March 2011; p ublished online January 2011 .
Journal Article. Subjects: Medical Oncology; Critical Care. 2665 words.
Objectives
The aim of this study was to elucidate the role of two novel membrane fusion proteins (MFPs) in the susceptibility of Acinetobacter baumannii to...
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DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis
in Journal of Antimicrobial Chemotherapy
February 2010; p ublished online November 2009 .
Journal Article. Subjects: Medical Oncology; Critical Care. 7410 words.
Objectives
The influenza virus (IFV) infection models commonly used to evaluate antiviral agents (e.g. MDCK cell line and mice) are limited by physiological...
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Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART
in Journal of Antimicrobial Chemotherapy
February 2003; p ublished online February 2003 .
Journal Article. Subjects: Medical Oncology; Critical Care. 2662 words.
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Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza—author's response
in Journal of Antimicrobial Chemotherapy
August 2008; p ublished online June 2008 .
Journal Article. Subjects: Medical Oncology; Critical Care. 416 words.
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Comment on: Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza
in Journal of Antimicrobial Chemotherapy
August 2008; p ublished online April 2008 .
Journal Article. Subjects: Medical Oncology; Critical Care. 1367 words.
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Killing kinetics of intracellular Afipia felis treated with amikacin.
in Journal of Antimicrobial Chemotherapy
December 1998; p ublished online December 1998 .
Journal Article. Subjects: Medical Oncology; Critical Care. 0 words.
Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for...
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Recombination of plasmids in a carbapenem-resistant NDM-5-producing clinical Escherichia coli isolate
in Journal of Antimicrobial Chemotherapy
May 2018; p ublished online January 2018 .
Journal Article. Subjects: Medical Oncology; Critical Care. 2297 words.
Abstract
Objectives
To investigate the genetic features of five plasmids recovered from an NDM-5-producing clinical null...
Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains
in Journal of Antimicrobial Chemotherapy
June 2014; p ublished online February 2014 .
Journal Article. Subjects: Medical Oncology; Critical Care. 5402 words.
Objectives
To develop new HIV-1 fusion inhibitors with improved antiviral activities and resistance profiles, we designed two categories of artificial...
Inhibition of respiratory syncytial virus by RhoA-derived peptides: implications for the development of improved antiviral agents targeting heparin-binding viruses
in Journal of Antimicrobial Chemotherapy
August 2004; p ublished online August 2004 .
Journal Article. Subjects: Medical Oncology; Critical Care. 3135 words.
The respiratory syncytial virus (RSV) fusion glycoprotein (F) can interact with the small intracellular GTPase RhoA, and peptides derived from RhoA inhibit RSV replication. These...
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Effect of substrate exposure and other growth condition manipulations on norA expression
in Journal of Antimicrobial Chemotherapy
August 2004; p ublished online August 2004 .
Journal Article. Subjects: Medical Oncology; Critical Care. 4722 words.
Objectives: Multidrug efflux is a resistance mechanism that simultaneously affects susceptibility to many structurally unrelated compounds. The regulation of norA expression,...
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Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni
in Journal of Antimicrobial Chemotherapy
January 2006; p ublished online November 2005 .
Journal Article. Subjects: Medical Oncology; Critical Care. 6028 words.
Objectives: To determine the role of CmeDEF in conferring antimicrobial resistance in Campylobacter jejuni and examine the interaction of CmeABC and CmeDEF in mediating...
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Evaluation of the AID ESBL line probe assay for rapid detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes in Enterobacteriaceae
in Journal of Antimicrobial Chemotherapy
January 2014; p ublished online September 2013 .
Journal Article. Subjects: Medical Oncology; Critical Care. 3571 words.
Objectives
This study aimed at evaluating the AID ESBL line probe assay for the detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes...
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