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fusion

Overview page. Subjects: Medicine and Health.

n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...

See overview in Oxford Index

PDTM-40. PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER.

Payal Jain, Tamara Fierst, Harry Han, Tiffany Smith, Phillip B Storm, Angela J Waanders and Adam C Resnick.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Pediatric low-grade gliomas (PLGGs) are the most common brain tumors in children mainly defined by activating gene fusions that dysregulate the...

O2.06USE OF MRI FUSION FOR CT BASED INTRACRANIAL STEREOTACTIC RADIOSURGERY

H.B. Caglar, A. Yildirim Altinok, E. Kucukmorkoc, H. Acar and N. Kucuk.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

The aim of this study is to evaluate the reliability of MRI fusion when determining intracranial target volume when performing CT based intracranial stereotactic radiosurgery. Patients...

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P05.02KIAA1549:BRAF FUSION GENE IN PEDIATRIC BRAIN TUMORS OF VARIOUS HISTOGENESIS

C. Baldi, M. Antonelli, M. Badiali, F.R. Buttarelli, L. Moi, P. Nozza, A. Arcella, M. Massimino, M. Sanson and F. Giangaspero.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Pediatric GBMs (pGBM) are histologically indistinguishable from adult GBM (aGBM) however they are molecularly distinct. Few molecular data exists on the mechanism underlying...

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TMOD-29. DEVELOPMENT OF PRECLINICAL GLIOMA MOUSE MODELS FOR GENE FUSIONS

Barbara Oldrini, Carolina Marques and Massimo Squatrito.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

The occurrence and importance of gene fusions in glioma has been appreciated only recently, largely due to high throughput technologies, and gene...

P04.01RELA FUSION DEFINES CLINICOPATHOLOGIC SUBSETS OF SUPRATENTORIAL EPENDYMOMA: A STUDY FROM THE COLLABORATIVE EPENDYMOMA RESEARCH NETWORK

K. Wani, E. Vera-Bolanos, T. Armstrong, S. Pfister, D. Jones, H. Witt, K. Pajter, M. Kool, M. Gilbert and K. Aldape.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

A novel fusion involving C11ORF95 and RelA was recently described in supratentorial ependymomas. We sought to further characterize the clinical relevance of this fusion. We evaluated a...

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BI-30CHARACTERIZATION OF L1CAM AS A CLINICAL MARKER FOR THE C11orf95-RELA FUSION IN SUPRATENTORIAL EPENDYMOMAS

Khalida Wani, Terri S. Armstrong, David T. Jones, Elizabeth Vera-Bolanos, Hendrik Witt, David Capper, Stefan M. Pfister, Richard J. Gilbertson, Mark R. Gilbert and Kenneth Aldape.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: Recently, a novel oncogenic fusion involving C11orf95 and RELA genes was described in a subset of supratentorial ependymoma causing aberrant activation of the NF-κB pathway....

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P05.04A COMBINED STRATEGY FOR THE DETECTION OF BRAF FUSIONS IN PILOCYTIC ASTROCYTOMA USING RT-PCR AND FISH

H.R. Haynes.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Pilocytic astrocytomas (WHO grade I) are the most common paediatric gliomas. The FISH test for KIAA1549-BRAF fusions is most commonly used, but this is difficult to interpret....

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OP32A COMBINED STRATEGY FOR THE DETECTION OF BRAF FUSIONS IN PILOCYTIC ASTROCYTOMA USING RT-PCR AND FISH

C. Faulkner, A. Shaw, C. Wragg, M. Greenslade, H. Haynes, H. Williams, S. Lowis, M. Williams and K.M. Kurian.

in Neuro-Oncology

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

INTRODUCTION: Pilocytic astrocytomas can show a wide morphological spectrum making definitive histological diagnosis challenging. The FISH test for KIAA1549-BRAF fusions is most commonly...

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PM-15C11orf95-RELA FUSION ALONE IS SUFFICIENT TO FORM HUMAN SUPRATENTORIAL EPENDYMOMA-LIKE TUMOR IN MICE

Tatsuya Ozawa, David Ellison, Richard Gilbertson and Eric Holland.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Ependymomas (EMs) are primary tumors of the central nervous system that preferentially occur in children. Recent deep molecular analyses have revealed that these tumors are divided into...

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O6.07FGFR3-TACC3 AND EGFR-SEPT14 GENE FUSIONS IN ADULT GLIOMAS

A. L. Di Stefano, M. Labussiere, V. Frattini, A. Fucci, B. Boisselier, Y. Schmitt, K. Mokhtari, A. Lasorella, A. Iavarone and M. Sanson.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Novel chromosomal rearrangements involving tyrosine-kinase receptors FGFR3 and EGFR and resulting in actionable fusion proteins with strong oncogenic activity have been recently described...

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Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas

Kirsi J Granberg, Matti Annala, Birgitta Lehtinen, Juha Kesseli, Joonas Haapasalo, Pekka Ruusuvuori, Olli Yli-Harja, Tapio Visakorpi, Hannu Haapasalo, Matti Nykter and Wei Zhang.

in Neuro-Oncology

September 2017; p ublished online April 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 5757 words.

Abstract

Background

Inhibitors of fibroblast growth factor receptors (FGFRs) have recently arisen as a promising...

GENE-44. CHROMOTHRIPSIS LEADS TO CHROMOSOMAL REARRANGEMENTS AND GENE FUSIONS IN PRIMARY GLIOBLASTOMAS

Audrey Rousseau, Anne Coutolleau, Philippe Menei, Philippe Guardiola and Blandine Boisselier.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Glioblastoma (GB) is the most frequent and lethal form of diffuse glioma. GB displays...

EPEN-19. SUPRATENTORIAL EPENDYMOMAS - L1CAM EXPRESSION AND RELA FUSION, THEIR CORRELATION WITH CLINICOPATHOLOGICAL FEATURES

Gouri Anvekar, Mamta Gurav, Omshree Shetty, Vinayak Kadam, Ayushi Sahay, Girish Chinnaswamy, Prakash Shetty, Aliasgar Moiyadi, Tejpal Gupta, Rakesh Jalali and Sridhar Epari.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

This study was undertaken to evaluate the frequency of RELA fusion 1/2 in supratentorial...

Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma

Aurélie Bruno, Karim Labreche, Maïlys Daniau, Blandine Boisselier, Guillaume Gauchotte, Louis Royer-Perron, Amithys Rahimian, Frédéric Lemoine, Pierre de la Grange, Justine Guégan, Franck Bielle, Marc Polivka, Clovis Adam, David Meyronet, Dominique Figarella-Branger, Chiara Villa, Fabrice Chrétien, Sandrine Eimer, Frédéric Davi, Audrey Rousseau, Caroline Houillier, Carole Soussain, Karima Mokhtari, Khê Hoang-Xuan and Agusti Alentorn.

in Neuro-Oncology

July 2018; p ublished online February 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 4815 words.

Abstract

Background

Primary central nervous system lymphoma (PCNSL) represents a particular entity within...

KIAA1549:BRAF FUSION GENE IN PEDIATRIC BRAIN TUMORS OF DIFFERENT HISTOGENESIS

Felice Giangaspero, Manila Antonelli, Manuela Badiali, Francesca R. Buttarelli, Loredana Moi and Marc Sanson.

in Neuro-Oncology

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: The KIAA1549:BRAF fusion (K-B fusion) gene has been considered a driver genetic events and a useful diagnostic marker in pilocytic astrocytomas (PA). However B-K gene fusion has...

C11ORF95-RELA FUSIONS DRIVE ONCOGENIC NF-KB SIGNALING IN EPENDYMOMA

Richard Gilbertson, Matthew Parker, Kumarasamypet M. Mohankumar, Chandanamali Punchihewa, Ricardo Weinlich, James D. Dalton, Yongjin Li, Ryan Lee, Ruth G. Tatevossian, Timothy N. Phoenix, Radhika Thiruvenkatam, Elsie White, Bo Tang, Wilda Orisme, Kirti Gupta, Michael Rusch, Xiang Chen, Yuxin Li, Panduka Nagahawhatta, Erin Hedlund, David Finkelstein, Gang Wu, Sheila Shurtleff, John Easton, Kristy Boggs, Donald Yergeau, Bhavin Vadodaria, Heather L. Mulder, Jared Becksford, Pankaj Gupta, Robert Huether, Jing Ma, Guangchun Song, Amar Gajjar, Thomas Merchant, Frederick Boop, Amy A Smith, Li Ding, Charles Lu, Kerri Ochoa, David Zhao, Robert S. Fulton, Lucinda L. Fulton, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Douglas R. Green, Jinghui Zhang, David W. Ellison and Richard J. Gilbertson.

in Neuro-Oncology

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: The nuclear factor-kB (NF-kB) family of transcriptional regulators are central mediators of the cellular inflammatory response. Although constitutive NF-kB signaling is present...

P04.78 Ultrarapid FGFR3 immunostaining for diagnosis of gliomas harboring FGFR3 gene fusions

S Mäntylä, J Haapasalo, J Ilvesaro, K Nordfors, J Isola, H Haapasalo, M Nykter and K Granberg.

in Neuro-Oncology

September 2018; p ublished online September 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Background

Fibroblast growth factor receptor 3 (FGFR3) gene fusion with transforming acidic coiled coil 3...

EPEN-25. KANSL1 GAIN AND FUSION - A NOVEL ALTERATION IN CHILDHOOD EPENDYMOMA

Yulia Margolin-Miller, Helen Toledano, Lital Sela-Tzuriano, Michal Hameiri-Grossman, Shalom Michowiz, Suzanna Fichman-Horn, Meora Feinmesser, Stefan Pfister, Hendrik Witt, Isaac Yaniv and Smadar Avigad.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Ependymoma is a malignant pediatric brain tumor, often incurable with current treatment regimens. We aimed to identify new genes involved in pediatric...

P08.20EGFR MUTATIONS STATUS AND EML4 ALK FUSION IN PATIENTS WITH BRAIN METASTASES FROM NON-SMALL CELL LUNG CANCER (NSCLC) AND SURVIVAL ANALYSIS: A RETROSPECTIVE STUDY

A.D. Muggeri, B. Calabrese, S. Cerrato and B.D. Diez.

in Neuro-Oncology

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Patients with EGFR mutation may have prolonged OS after diagnosis of brain metastases independent of treatment strategy. Tumor harbouring EGFR mutation with brain metastases from NSCLC is...

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PATH-48. FUSION TESTING IN ADULT VERSUS PEDIATRIC LOW AND HIGH GRADE BRAIN TUMORS FOR ELIGIBILITY FOR TRIALS

David Ormond, Denise Damek, Nicholas Willard, Mark Ewalt and Bette Kleinschmidt-DeMasters.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Since January 2017, our molecular laboratory has assessed 47 pediatric and 23 adult primary...