Oxford Index Search Results

You are looking at 1-20 of 53 items for:

fusion x Medical Oncology x Critical Care x Clinical Medicine x clear all

Refine by type

Refine by product

 

fusion

Overview page. Subjects: Medicine and Health.

n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...

See overview in Oxford Index

Resistance to enfuvirtide, the first HIV fusion inhibitor

Michael L. Greenberg and Nick Cammack.

in Journal of Antimicrobial Chemotherapy

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6849 words.

Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human immunodeficiency virus infection. Enfuvirtide is the first in this class to reach market approval....

Go to »  abstract

Clinical perspective of fusion inhibitors for treatment of HIV

J. K. Rockstroh and S. Mauss.

in Journal of Antimicrobial Chemotherapy

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2249 words.

The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options...

Go to »  abstract

Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor

Christopher Cianci, Nicholas Meanwell and Mark Krystal.

in Journal of Antimicrobial Chemotherapy

March 2005; p ublished online March 2005 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2848 words.

BMS-433771 is an orally bioavailable respiratory syncytial virus (RSV) inhibitor, functioning through inhibition of viral F protein-induced membrane fusion. The compound is active against...

Go to »  abstract

Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza

Hong Zhang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online January 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 3644 words.

Sialidase fusion protein is reported to have great potential to combat seasonal and pandemic influenza, because it may prevent influenza virus infection by removing all sialic acid...

Go to »  abstract

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure

Marcelo T. Augusto, Axel Hollmann, Miguel A. R. B. Castanho, Matteo Porotto, Antonello Pessi and Nuno C. Santos.

in Journal of Antimicrobial Chemotherapy

May 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7143 words.

Objectives

The aim of the present work was to evaluate the interaction of two new HIV fusion inhibitors {HIVP3 [C34–polyethylene glycol (PEG)4–cholesterol]...

Go to »  abstract

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181

Gallen B. Triana-Baltzer, Rebecca L. Sanders, Maria Hedlund, Kellie A. Jensen, Laura M. Aschenbrenner, Jeffrey L. Larson and Fang Fang.

in Journal of Antimicrobial Chemotherapy

January 2011; p ublished online November 2010 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7713 words.

Background

Influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of...

Go to »  abstract

The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance

Huihui Chong, Xue Yao, Zonglin Qiu, Jianping Sun, Yuanyuan Qiao, Meng Zhang, Meitian Wang, Sheng Cui and Yuxian He.

in Journal of Antimicrobial Chemotherapy

October 2014; p ublished online June 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6185 words.

Objectives

Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 are potent fusion inhibitors. We have recently demonstrated that the unique...

Viral receptor blockage by multivalent recombinant antibody fusion proteins: inhibiting human rhinovirus (HRV) infection with CFY196

Fang Fang and Mang Yu.

in Journal of Antimicrobial Chemotherapy

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2236 words.

Viral receptor blockage by monoclonal antibodies (mAbs) is a common strategy to inhibit viral infection; however, no drug candidate acting by this mechanism has reached the market so far....

Go to »  abstract

Molecular cloning and functional characterization of two novel membrane fusion proteins in conferring antimicrobial resistance in Acinetobacter baumannii

Vijaya Bharathi Srinivasan, Govindan Rajamohan, Preeti Pancholi, Mario Marcon and Wondwossen A. Gebreyes.

in Journal of Antimicrobial Chemotherapy

March 2011; p ublished online January 2011 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2665 words.

Objectives

The aim of this study was to elucidate the role of two novel membrane fusion proteins (MFPs) in the susceptibility of Acinetobacter baumannii to...

Go to »  abstract

DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis

Gallen B. Triana-Baltzer, Maria Babizki, Michael C. W. Chan, Adam C. N. Wong, Laura M. Aschenbrenner, Erin R. Campbell, Qi-Xiang Li, Renee W. Y. Chan, J. S. Malik Peiris, John M. Nicholls and Fang Fang.

in Journal of Antimicrobial Chemotherapy

February 2010; p ublished online November 2009 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7410 words.

Objectives

The influenza virus (IFV) infection models commonly used to evaluate antiviral agents (e.g. MDCK cell line and mice) are limited by physiological...

Go to »  abstract

Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART

Graeme Moyle.

in Journal of Antimicrobial Chemotherapy

February 2003; p ublished online February 2003 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2662 words.

Go to »  abstract

Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza—author's response

Hong Zhang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online June 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 416 words.

Go to »  abstract

Comment on: Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza

John M. Nicholls, Laura M. Aschenbrenner, James C. Paulson, Erin R. Campbell, Michael P. Malakhov, David F. Wurtman, Mang Yu and Fang Fang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online April 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 1367 words.

Go to »  abstract

Killing kinetics of intracellular Afipia felis treated with amikacin.

H Le Pocher, P Brouqui and D Raoult.

in Journal of Antimicrobial Chemotherapy

December 1998; p ublished online December 1998 .

Journal Article. Subjects: Medical Oncology; Critical Care. 0 words.

Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for...

Go to »  abstract

Recombination of plasmids in a carbapenem-resistant NDM-5-producing clinical Escherichia coli isolate

Miaomiao Xie, Ruichao Li, Zhonghua Liu, Edward Wai Chi Chan and Sheng Chen.

in Journal of Antimicrobial Chemotherapy

May 2018; p ublished online January 2018 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2297 words.

Abstract

Objectives

To investigate the genetic features of five plasmids recovered from an NDM-5-producing clinical null...

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains

Chao Wang, Weiguo Shi, Lifeng Cai, Lu Lu, Fei Yu, Qian Wang, Xifeng Jiang, Xiaoyu Xu, Kun Wang, Liang Xu, Shibo Jiang and Keliang Liu.

in Journal of Antimicrobial Chemotherapy

June 2014; p ublished online February 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 5402 words.

Objectives

To develop new HIV-1 fusion inhibitors with improved antiviral activities and resistance profiles, we designed two categories of artificial...

Inhibition of respiratory syncytial virus by RhoA-derived peptides: implications for the development of improved antiviral agents targeting heparin-binding viruses

Philip J. Budge and Barney S. Graham.

in Journal of Antimicrobial Chemotherapy

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 3135 words.

The respiratory syncytial virus (RSV) fusion glycoprotein (F) can interact with the small intracellular GTPase RhoA, and peptides derived from RhoA inhibit RSV replication. These...

Go to »  abstract

Effect of substrate exposure and other growth condition manipulations on norA expression

Glenn W. Kaatz and Susan M. Seo.

in Journal of Antimicrobial Chemotherapy

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 4722 words.

Objectives: Multidrug efflux is a resistance mechanism that simultaneously affects susceptibility to many structurally unrelated compounds. The regulation of norA expression,...

Go to »  abstract

Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni

Masato Akiba, Jun Lin, Yi-Wen Barton and Qijing Zhang.

in Journal of Antimicrobial Chemotherapy

January 2006; p ublished online November 2005 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6028 words.

Objectives: To determine the role of CmeDEF in conferring antimicrobial resistance in Campylobacter jejuni and examine the interaction of CmeABC and CmeDEF in mediating...

Go to »  abstract

Evaluation of the AID ESBL line probe assay for rapid detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes in Enterobacteriaceae

Guido V. Bloemberg, Silke Polsfuss, Vera Meyer, Erik C. Böttger and Michael Hombach.

in Journal of Antimicrobial Chemotherapy

January 2014; p ublished online September 2013 .

Journal Article. Subjects: Medical Oncology; Critical Care. 3571 words.

Objectives

This study aimed at evaluating the AID ESBL line probe assay for the detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes...

Go to »  abstract