Oxford Index Search Results

You are looking at 1-20 of 72 items for:

fusion x Critical Care x clear all

Show only full text

Refine by type

Refine by product

 

fusion

Overview page. Subjects: Medicine and Health.

n. the joining together of two structures. For example, the surgical fusion of two or more vertebrae is performed to stabilize an unstable spine. Fusion of the epiphyses during...

See overview in Oxford Index

Resistance to enfuvirtide, the first HIV fusion inhibitor

Michael L. Greenberg and Nick Cammack.

in Journal of Antimicrobial Chemotherapy

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6849 words.

Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human immunodeficiency virus infection. Enfuvirtide is the first in this class to reach market approval....

Go to »  full text   » abstract

Clinical perspective of fusion inhibitors for treatment of HIV

J. K. Rockstroh and S. Mauss.

in Journal of Antimicrobial Chemotherapy

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2249 words.

The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options...

Go to »  full text   » abstract

Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action

A.J.G. Pötgens, S. Drewlo, M. Kokozidou and P. Kaufmann.

in Human Reproduction Update

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Critical Care; Reproductive Medicine. 8841 words.

Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein...

Go to »  abstract

Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor

Christopher Cianci, Nicholas Meanwell and Mark Krystal.

in Journal of Antimicrobial Chemotherapy

March 2005; p ublished online March 2005 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2848 words.

BMS-433771 is an orally bioavailable respiratory syncytial virus (RSV) inhibitor, functioning through inhibition of viral F protein-induced membrane fusion. The compound is active against...

Go to »  full text   » abstract

Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza

Hong Zhang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online January 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 3644 words.

Sialidase fusion protein is reported to have great potential to combat seasonal and pandemic influenza, because it may prevent influenza virus infection by removing all sialic acid...

Go to »  full text   » abstract

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure

Marcelo T. Augusto, Axel Hollmann, Miguel A. R. B. Castanho, Matteo Porotto, Antonello Pessi and Nuno C. Santos.

in Journal of Antimicrobial Chemotherapy

May 2014; p ublished online January 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7143 words.

Objectives

The aim of the present work was to evaluate the interaction of two new HIV fusion inhibitors {HIVP3 [C34–polyethylene glycol (PEG)4–cholesterol]...

Go to »  full text   » abstract

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181

Gallen B. Triana-Baltzer, Rebecca L. Sanders, Maria Hedlund, Kellie A. Jensen, Laura M. Aschenbrenner, Jeffrey L. Larson and Fang Fang.

in Journal of Antimicrobial Chemotherapy

January 2011; p ublished online November 2010 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7713 words.

Background

Influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of...

Go to »  full text   » abstract

The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance

Huihui Chong, Xue Yao, Zonglin Qiu, Jianping Sun, Yuanyuan Qiao, Meng Zhang, Meitian Wang, Sheng Cui and Yuxian He.

in Journal of Antimicrobial Chemotherapy

October 2014; p ublished online June 2014 .

Journal Article. Subjects: Medical Oncology; Critical Care. 6185 words.

Objectives

Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 are potent fusion inhibitors. We have recently demonstrated that the unique...

Go to »  full text

Viral receptor blockage by multivalent recombinant antibody fusion proteins: inhibiting human rhinovirus (HRV) infection with CFY196

Fang Fang and Mang Yu.

in Journal of Antimicrobial Chemotherapy

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2236 words.

Viral receptor blockage by monoclonal antibodies (mAbs) is a common strategy to inhibit viral infection; however, no drug candidate acting by this mechanism has reached the market so far....

Go to »  full text   » abstract

Molecular cloning and functional characterization of two novel membrane fusion proteins in conferring antimicrobial resistance in Acinetobacter baumannii

Vijaya Bharathi Srinivasan, Govindan Rajamohan, Preeti Pancholi, Mario Marcon and Wondwossen A. Gebreyes.

in Journal of Antimicrobial Chemotherapy

March 2011; p ublished online January 2011 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2665 words.

Objectives

The aim of this study was to elucidate the role of two novel membrane fusion proteins (MFPs) in the susceptibility of Acinetobacter baumannii to...

Go to »  full text   » abstract

DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis

Gallen B. Triana-Baltzer, Maria Babizki, Michael C. W. Chan, Adam C. N. Wong, Laura M. Aschenbrenner, Erin R. Campbell, Qi-Xiang Li, Renee W. Y. Chan, J. S. Malik Peiris, John M. Nicholls and Fang Fang.

in Journal of Antimicrobial Chemotherapy

February 2010; p ublished online November 2009 .

Journal Article. Subjects: Medical Oncology; Critical Care. 7410 words.

Objectives

The influenza virus (IFV) infection models commonly used to evaluate antiviral agents (e.g. MDCK cell line and mice) are limited by physiological...

Go to »  full text   » abstract

231 Decrease of Mitochondrial Fusion Protein MFN1 and Associated Myogenin Inhibition in Response to Severe Burn

N Karbhari, C Geng, J Song and S Wolf.

in Journal of Burn Care & Research

April 2018; p ublished online April 2018 .

Journal Article. Subjects: Medicine and Health; Acute Medicine; Emergency Medicine; Critical Care; Surgery. 0 words.

Abstract

Introduction

Severe burn-induced muscle mass loss is primarily a result of protein degradation and...

Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART

Graeme Moyle.

in Journal of Antimicrobial Chemotherapy

February 2003; p ublished online February 2003 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2662 words.

Go to »  full text   » abstract

Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza—author's response

Hong Zhang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online June 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 416 words.

Go to »  full text   » abstract

Comment on: Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza

John M. Nicholls, Laura M. Aschenbrenner, James C. Paulson, Erin R. Campbell, Michael P. Malakhov, David F. Wurtman, Mang Yu and Fang Fang.

in Journal of Antimicrobial Chemotherapy

August 2008; p ublished online April 2008 .

Journal Article. Subjects: Medical Oncology; Critical Care. 1367 words.

Go to »  full text   » abstract

Shock

Carl Waldmann, Neil Soni and Andrew Rhodes.

in Oxford Desk Reference: Critical Care

November 2008; p ublished online October 2011 .

Chapter. Subjects: Critical Care. 7148 words.

Shock: definition and diagnosis 446

Hypovolaemic shock 450

Cardiogenic shock 452

Anaphylactic...

Go to »  abstract

The molecular basis of sperm–oocyte membrane interactions during mammalian fertilization

Janice P. Evans.

in Human Reproduction Update

July 2002; p ublished online July 2002 .

Journal Article. Subjects: Critical Care; Reproductive Medicine. 0 words.

Gamete membrane interactions begin with adhesion (binding) of the sperm to the oocyte plasma membrane and culminate with fusion of the membranes of the gametes, thus creating the zygote...

Go to »  abstract

Oocyte activation, phospholipase C zeta and human infertility

J. Kashir, B. Heindryckx, C. Jones, P. De Sutter, J. Parrington and K. Coward.

in Human Reproduction Update

January 2010; p ublished online June 2010 .

Journal Article. Subjects: Critical Care; Reproductive Medicine. 9381 words.

BACKGROUND

Mammalian oocytes are activated by intracellular calcium (Ca2+) oscillations following gamete fusion. Recent evidence implicates a sperm-specific...

Go to »  abstract

The history of female genital tract malformation classifications and proposal of an updated system

Pedro Acién and Maribel I. Acién.

in Human Reproduction Update

January 2011; p ublished online July 2011 .

Journal Article. Subjects: Critical Care; Reproductive Medicine. 8135 words.

BACKGROUND

A correct classification of malformations of the female genital tract is essential to prevent unnecessary and inadequate surgical operations and...

Go to »  abstract

The effects of oestrogens on linear bone growth

Anders Juul.

in Human Reproduction Update

May 2001; p ublished online May 2001 .

Journal Article. Subjects: Critical Care; Reproductive Medicine. 0 words.

Regulation of linear bone growth in children and adolescents comprises a complex interaction of hormones and growth factors. Growth hormone (GH) is considered to be the key hormone...

Go to »  abstract