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secretory proteins

Overview page. Subjects: Medicine and Health.

A diverse group of proteins, nearly all of which are synthesized on the rough endoplasmic reticulum, cotranslationally transported into the lumen of the endoplasmic reticulum (see signal...

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Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse

Yajing Peng, Mi Jin Kim, Rikki Hullinger, Kenneth J. O’Riordan, Corinna Burger, Mariana Pehar and Luigi Puglielli.

in Brain

March 2016; p ublished online January 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 8147 words.

See Duran-Aniotz et al. (doi:10.1093/brain/awv401) for a scientific commentary on this article.

The aberrant accumulation of toxic protein aggregates is a...

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Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

Masato Kanazawa, Kunio Kawamura, Tetsuya Takahashi, Minami Miura, Yoshinori Tanaka, Misaki Koyama, Masafumi Toriyabe, Hironaka Igarashi, Tsutomu Nakada, Masugi Nishihara, Masatoyo Nishizawa and Takayoshi Shimohata.

in Brain

July 2015; p ublished online April 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 8668 words.

In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding...

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GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum

Evangelia Emmanouilidou, Georgia Minakaki, Maria V. Keramioti, Mary Xylaki, Evangelos Balafas, Margarita Chrysanthou-Piterou, Ismini Kloukina and Kostas Vekrellis.

in Brain

March 2016; p ublished online February 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 11787 words.

α-Synuclein is readily released in human and mouse brain parenchyma, even though the normal function of the secreted protein has not been yet elucidated. Under pathological conditions, such...

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