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Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

See overview in Oxford Index

temperature-sensitive mutation

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 49 words.

A conditional mutation (ts mutation), one that is only expressed at certain temperatures, usually because the nonpermissive temperature causes conformational instability in an essential...

Voltage-Sensitive Dye Imaging

William Frost and Jian-young Wu.

in Basic Electrophysiological Methods

February 2015; p ublished online April 2015 .

Chapter. Subjects: Neurology. 10970 words.

Voltage sensitive dye imaging (VSD) can be used to record neural activity in hundreds of locations in preparations ranging from mammalian cortex to invertebrate ganglia. Because fast VSDs...

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A sensitive and specific ELISA for plasma pentosidine.

Y Izuhara, T Miyata, Y Ueda, D Suzuki, K Asahi, R Inagi, H Sakai and K Kurokawa.

in Nephrology Dialysis Transplantation

March 1999; p ublished online March 1999 .

Journal Article. Subjects: Nephrology. 0 words.

BACKGROUND: Advanced glycation end products are formed by non-enzymatic glycation and oxidation reaction. Pentosidine is a well-known and characterized structure among them, and has been...

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Ultrasonography is a sensitive tool for monitoring localized scleroderma

S. C. Li, M. S. Liebling and K. A. Haines.

in Rheumatology

August 2007; p ublished online May 2007 .

Journal Article. Subjects: Rheumatology. 2619 words.

Objective. To examine the usefulness of ultrasonography (USG) for monitoring paediatric localized scleroderma (LS).

Methods. A retrospective chart review...

Relaxin ameliorates salt-sensitive hypertension and renal fibrosis

Takuya Yoshida, Hiromichi Kumagai, Ayumi Suzuki, Natsuki Kobayashi, Sakae Ohkawa, Mari Odamaki, Tetsuya Kohsaka, Tatsuo Yamamoto and Naoki Ikegaya.

in Nephrology Dialysis Transplantation

June 2012; p ublished online November 2011 .

Journal Article. Subjects: Nephrology. 4876 words.


Although relaxin (RLX) has potent vasodilatory and anti-fibrotic properties, there is no information on its effects on salt-sensitive...

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Cell volume-sensitive ion channels and transporters in cardiac myocytes

Clive M. Baumgarten, Wu Deng and Frank J. Raucci.

in Cardiac Mechano-Electric Coupling and Arrhythmias

August 2011; p ublished online November 2013 .

Chapter. Subjects: Cardiovascular Medicine. 6613 words.

In addition to stretch-activated channels (SAC) that respond to purely mechanical stimuli (e.g. Chapter 2), the heart possesses voltage- and ligand-gated channels and ion transporters that...

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The diabetic heart is more sensitive to ischemic injury

Dennis J Paulson.

in Cardiovascular Research

April 1997; p ublished online April 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 7146 words.


Clinical studies have suggested that the diabetic heart is more sensitive to ischemic injury than the non-diabetic heart. However, results from a...

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Mechano-sensitive channel blockers: a new class of antiarrhythmic drugs?

Ed White.

in Cardiac Mechano-Electric Coupling and Arrhythmias

August 2011; p ublished online November 2013 .

Chapter. Subjects: Cardiovascular Medicine. 4286 words.

The activation of mechano-sensitive ion channels (MSC) has been implicated in the generation of stretch-activated cardiac arrhythmias, which are reported to be more prevalent in diseased...

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Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes

Luis Agulló, David Garcia-Dorado, Noelia Escalona, Marisol Ruiz-Meana, Maribel Mirabet, Javier Inserte and Jordi Soler-Soler.

in Cardiovascular Research

October 2005; p ublished online October 2005 .

Journal Article. Subjects: Cardiovascular Medicine. 6055 words.


Objective: Although the importance of the cyclic GMP (cGMP) signaling pathway in cardiac myocytes is well established, little is known...

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Development and Evaluation of a Sensitive Mycotoxin Risk Assessment Model (MYCORAM)

Hester-Mari Burger, Martani J. Lombard, Gordon S. Shephard, Natasha Danster-Christians and Wentzel C.A. Gelderblom.

in Toxicological Sciences

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Medical Toxicology. 8858 words.

The differential risk of exposure to fumonisin (FB), deoxynivalenol (DON), and zearalenone (ZEA) mycotoxins to the South African population, residing in the nine Provinces was assessed...

Differential Involvement of Conotoxin-Sensitive Mechanisms in Neurogenic Vasodilatation Responses

Zeinab Khalil, Merhi Merhi and Bruce G. Livett.

in The Journals of Gerontology: Series A

August 2001; p ublished online August 2001 .

Journal Article. Subjects: Geriatric Medicine; Biological Sciences. 5849 words.

During aging there is a decline in sensory nerve function that is associated with reduced neurogenic inflammation and poor wound repair. The cellular mechanism(s) responsible for this...

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Ochratoxin A Content of Human Sera Determined by a Sensitive ELISA

László Solti, Ferenc Salamon, Ildikó Barna-Vetró, Ágnes Gyöngyösi, Erzsébet Szabó and Anna Wölfling.

in Journal of Analytical Toxicology

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

A sensitive, monoclonal antibody-based ELISA test was developed and used for quantitative determination of ochratoxin A (OA) in human sera. The measuring range of this test (without sample...

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Cortisol fluctuations relate to interictal epileptiform discharges in stress sensitive epilepsy

Jolien S. van Campen, E. Lorraine Hompe, Floor E. Jansen, Demetrios N. Velis, Willem M. Otte, Fia van de Berg, Kees P. J. Braun, Gerhard H. Visser, Josemir W. Sander, Marian Joels and Maeike Zijlmans.

in Brain

June 2016; p ublished online March 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System; Sleep Medicine. 4093 words.

People with epilepsy often report seizures precipitated by stress. This is believed to be due to effects of stress hormones, such as cortisol, on neuronal excitability. Cortisol, regardless...

Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi

Anne E. P. Frosch, Miriam K. Laufer, Don P. Mathanga, Shannon Takala-Harrison, Jacek Skarbinski, Cassidy W. Claassen, Fraction K. Dzinjalamala and Christopher V. Plowe.

in The Journal of Infectious Diseases

October 2014; p ublished online April 2014 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 2305 words.

Background.  The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in...

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Endothelin-1 inhibition of cardiac ATP-sensitive K+ channels via pertussis-toxin-sensitive G-proteins

Masato Watanuki, Minoru Horie, Kunihiko Tsuchiya, Kazuhiko Obayashi and Shigetake Sasayama.

in Cardiovascular Research

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 4094 words.


Objective: Secretion of endothelin-1 (ET-1) and activation of cardiac ATP-sensitive K+ (KATP) channels are facilitated under myocardial...

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Response of coronary microvascular collaterals to activation of ATP-sensitive K+ channels

Kathryn G Lamping, Daniel W Nuno, Leonard A Brooks and Mikio Fujii.

in Cardiovascular Research

August 1997; p ublished online August 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 4262 words.


Objective: Studies have suggested that collateral vessels of the coronary and hind-limb circulations are more sensitive to activation...

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Enhanced efficacy of pH-sensitive nystatin liposomes against Cryptococcus neoformans in murine model

Tahseen H. Nasti, Masood A. Khan and M. Owais.

in Journal of Antimicrobial Chemotherapy

February 2006; p ublished online December 2005 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2884 words.

Objectives: To evaluate the efficacy of pH-sensitive liposomes of nystatin against Cryptococcus neoformans infection in a murine model.

Methods: In the...

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Variably protease-sensitive prionopathy in the UK: a retrospective review 1991–2008

Mark W. Head, Helen M. Yull, Diane L. Ritchie, Jan P. Langeveld, Nicholas A. Fletcher, Richard S. Knight and James W. Ironside.

in Brain

April 2013; p ublished online April 2013 .

Journal Article. Subjects: Neurology; Neuroscience. 8912 words.

Variably protease-sensitive prionopathy is a newly described human prion disease of unknown aetiology lying out with the hitherto recognized phenotypic spectrum of Creutzfeldt–Jakob...

Fra-2 mediates oxygen-sensitive induction of transforming growth factor β in cardiac fibroblasts

Sashwati Roy, Savita Khanna, Ali Azad, Rebecca Schnitt, Guanglong He, Cora Weigert, Hidenori Ichijo and Chandan K. Sen.

in Cardiovascular Research

September 2010; p ublished online April 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 5088 words.


In the ischaemia-reperfused heart, transforming growth factor β (TGFβ) proteins trigger the differentiation of cardiac fibroblasts (CFs) contributing to...

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Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population

Ronald N. Hines, Dana Sargent, Herman Autrup, Linda S. Birnbaum, Robert L. Brent, Nancy G. Doerrer, Elaine A. Cohen Hubal, Daland R. Juberg, Christian Laurent, Robert Luebke, Klaus Olejniczak, Christopher J. Portier and William Slikker.

in Toxicological Sciences

January 2010; p ublished online September 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 16652 words.

Assessing the risk profiles of potentially sensitive populations requires a “tool chest” of methodological approaches to adequately characterize and evaluate these populations. At present,...