Oxford Index Search Results

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sensitive x Clinical Medicine x Cardiovascular Medicine x clear all

sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

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Cell volume-sensitive ion channels and transporters in cardiac myocytes

Clive M. Baumgarten, Wu Deng and Frank J. Raucci.

in Cardiac Mechano-Electric Coupling and Arrhythmias

August 2011; p ublished online November 2013 .

Chapter. Subjects: Cardiovascular Medicine. 6613 words.

In addition to stretch-activated channels (SAC) that respond to purely mechanical stimuli (e.g. Chapter 2), the heart possesses voltage- and ligand-gated channels and ion transporters that...

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The diabetic heart is more sensitive to ischemic injury

Dennis J Paulson.

in Cardiovascular Research

April 1997; p ublished online April 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 7146 words.

Abstract

Clinical studies have suggested that the diabetic heart is more sensitive to ischemic injury than the non-diabetic heart. However, results from a...

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Mechano-sensitive channel blockers: a new class of antiarrhythmic drugs?

Ed White.

in Cardiac Mechano-Electric Coupling and Arrhythmias

August 2011; p ublished online November 2013 .

Chapter. Subjects: Cardiovascular Medicine. 4286 words.

The activation of mechano-sensitive ion channels (MSC) has been implicated in the generation of stretch-activated cardiac arrhythmias, which are reported to be more prevalent in diseased...

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Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes

Luis Agulló, David Garcia-Dorado, Noelia Escalona, Marisol Ruiz-Meana, Maribel Mirabet, Javier Inserte and Jordi Soler-Soler.

in Cardiovascular Research

October 2005; p ublished online October 2005 .

Journal Article. Subjects: Cardiovascular Medicine. 6055 words.

Abstract

Objective: Although the importance of the cyclic GMP (cGMP) signaling pathway in cardiac myocytes is well established, little is known...

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Endothelin-1 inhibition of cardiac ATP-sensitive K+ channels via pertussis-toxin-sensitive G-proteins

Masato Watanuki, Minoru Horie, Kunihiko Tsuchiya, Kazuhiko Obayashi and Shigetake Sasayama.

in Cardiovascular Research

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 4094 words.

Abstract

Objective: Secretion of endothelin-1 (ET-1) and activation of cardiac ATP-sensitive K+ (KATP) channels are facilitated under myocardial...

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Response of coronary microvascular collaterals to activation of ATP-sensitive K+ channels

Kathryn G Lamping, Daniel W Nuno, Leonard A Brooks and Mikio Fujii.

in Cardiovascular Research

August 1997; p ublished online August 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 4262 words.

Abstract

Objective: Studies have suggested that collateral vessels of the coronary and hind-limb circulations are more sensitive to activation...

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Fra-2 mediates oxygen-sensitive induction of transforming growth factor β in cardiac fibroblasts

Sashwati Roy, Savita Khanna, Ali Azad, Rebecca Schnitt, Guanglong He, Cora Weigert, Hidenori Ichijo and Chandan K. Sen.

in Cardiovascular Research

September 2010; p ublished online April 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 5088 words.

Aims

In the ischaemia-reperfused heart, transforming growth factor β (TGFβ) proteins trigger the differentiation of cardiac fibroblasts (CFs) contributing to...

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Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism

Mareike Lankeit, Dietrich Friesen, John Aschoff, Claudia Dellas, Gerd Hasenfuß, Hugo Katus, Stavros Konstantinides and Evangelos Giannitsis.

in European Heart Journal

August 2010; p ublished online June 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 5711 words.

Aims

To assess the role of cardiac troponin T (cTnT) levels on admission using a new, highly sensitive assay (hsTnT) in the risk assessment of normotensive...

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The history of diagnosing carotid sinus hypersensitivity: why are the current criteria too sensitive?

C.T.P. (Paul) Krediet, Steve W. Parry, David L. Jardine, David G. Benditt, Michele Brignole and Wouter Wieling.

in EP Europace

January 2011; p ublished online November 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 6677 words.

The carotid sinus syndrome and carotid sinus hypersensitivity (CSH) are closely related disorders. The first is characterized by syncope triggered by manipulation of the carotid sinus in...

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Sensitive diagnosis of cardiac allograft rejection by detection of cytokine transcription in situ

Jun-ichi Suzuki, Mitsuaki Isobe, Satoshi Yamazaki, Shiro Horie, Yoshio Okubo and Morie Sekiguchi.

in Cardiovascular Research

November 1998; p ublished online November 1998 .

Journal Article. Subjects: Cardiovascular Medicine. 3345 words.

Abstract

Objective: In situ transcription of cytokines which are important in the development of cardiac rejection has not been evaluated for...

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Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats

Sangita Choudhury, Soochan Bae, Sheetal R. Kumar, Qingen Ke, Bhargavi Yalamarti, Jun H. Choi, Lorrie A. Kirshenbaum and Peter M. Kang.

in Cardiovascular Research

January 2010; p ublished online July 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4831 words.

Aims

The caspases are thought to be central mediators of the apoptotic program, but recent data indicate that apoptosis may also be mediated by...

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Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes

Vivek Garg, Jundong Jiao and Keli Hu.

in Cardiovascular Research

April 2009; p ublished online January 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 5361 words.

Aims

ATP-sensitive potassium (KATP) channels in the heart are critical regulators of cellular excitability and action potentials during ischaemia. However,...

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Plasma semicarbazide-sensitive amine oxidase is elevated in patients with congestive heart failure

Frans Boomsma, Dirk J van Veldhuisen, Pieter J de Kam, Arie J Man in 't Veld, Arend Mosterd, Kong I Lie and Maarten A.D.H Schalekamp.

in Cardiovascular Research

February 1997; p ublished online February 1997 .

Journal Article. Subjects: Cardiovascular Medicine. 2921 words.

Abstract

Objective: Semicarbazide-sensitive amine oxidase (SSAO) is present in various mammalian tissues, especially in vascular smooth muscle...

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Semicarbazide-sensitive amine oxidase catalyzes endothelial cell-mediated low density lipoprotein oxidation

Markus Exner, Marcela Hermann, Roland Hofbauer, Stylianos Kapiotis, Peter Quehenberger, Wolfgang Speiser, Irmtraud Held and Bernhard M.K Gmeiner.

in Cardiovascular Research

June 2001; p ublished online June 2001 .

Journal Article. Subjects: Cardiovascular Medicine. 3331 words.

Abstract

Objective: Deamination products of semicarbazide-sensitive amine oxidases (SSAO), i.e. aldehydes, superoxide and ammonia have been...

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Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes

Masafumi Takahashi, Jun Nishihira, Masahisa Shimpo, Yuka Mizue, Shuichi Ueno, Hiroyuki Mano, Eiji Kobayashi, Uichi Ikeda and Kazuyuki Shimada.

in Cardiovascular Research

December 2001; p ublished online December 2001 .

Journal Article. Subjects: Cardiovascular Medicine. 4424 words.

Abstract

Objective: Macrophage migration inhibitory factor (MIF), which plays a pivotal role in the control of inflammatory responses, was first...

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A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells

Hai Wang, Chaoliang Long, Zhibian Duan, Cuige Shi, Guodong Jia and Yingli Zhang.

in Cardiovascular Research

February 2007; p ublished online February 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 2963 words.

Abstract

Objective: Endothelial dysfunction is an early risk factor for cardiovascular disease and hypertension. Mechanisms that participate in...

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The acid-sensitive potassium channel TASK-1 in rat cardiac muscle

Caroline Putzke, Konstantin Wemhöner, Frank B. Sachse, Susanne Rinné, Günter Schlichthörl, Xian Tao Li, Lucas Jaé, Ines Eckhardt, Erhard Wischmeyer, Hinnerk Wulf, Regina Preisig-Müller, Jürgen Daut and Niels Decher.

in Cardiovascular Research

July 2007; p ublished online July 2007 .

Journal Article. Subjects: Cardiovascular Medicine. 5369 words.

Abstract

Objective The outward current flowing through the two-pore domain acid-sensitive potassium channel TASK-1 (I TASK) and its...

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Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes

Frank J. Raucci, Dayanjan S. Wijesinghe, Charles E. Chalfant and Clive M. Baumgarten.

in Cardiovascular Research

April 2010; p ublished online December 2009 .

Journal Article. Subjects: Cardiovascular Medicine. 4516 words.

Aims

Because ceramide accumulates in several forms of cardiovascular disease and ceramide-induced apoptosis may involve the volume-sensitive Cl current, Inull...

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Endothelin signalling regulates volume-sensitive Cl current via NADPH oxidase and mitochondrial reactive oxygen species

Wu Deng, Lia Baki and Clive M. Baumgarten.

in Cardiovascular Research

October 2010; p ublished online May 2010 .

Journal Article. Subjects: Cardiovascular Medicine. 4844 words.

Aims

We assessed regulation of volume-sensitive Cl current (I Cl,swell) by endothelin-1 (ET-1) and characterized the signalling pathway...

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Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres

Peter E. Light, Jonathan M. Cordeiro and Robert J. French.

in Cardiovascular Research

November 1999; p ublished online November 1999 .

Journal Article. Subjects: Cardiovascular Medicine. 8322 words.

Abstract

Objective: Our goal was to identify the ATP-sensitive potassium (KATP) channels in cardiac Purkinje cells and to document the...

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