Oxford Index Search Results

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sensitive x Clinical Medicine x Medical Oncology x clear all

sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

See overview in Oxford Index

A prognostic nomogram to predict overall survival in patients with platinum-sensitive recurrent ovarian cancer

C. K. Lee, R. J. Simes, C. Brown, V. Gebski, J. Pfisterer, A.-M. Swart, D. Berton-Rigaud, M. Plante, T. Skeie-Jensen, I. Vergote, C. Schauer, C. Pisano, G. Parma, K. Baumann, J. A. Ledermann, E. Pujade-Lauraine, J. Bentley, G. Kristensen, A. Belau, M. Nankivell, U. Canzler, S. J. Lord, C. Kurzeder and M. Friedlander.

in Annals of Oncology

April 2013; p ublished online October 2012 .

Journal Article. Subjects: Medical Oncology. 4092 words.

Background

Patients with platinum-sensitive recurrent ovarian cancer have variable prognosis and survival. We extend previous work on prediction of...

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Enhanced efficacy of pH-sensitive nystatin liposomes against Cryptococcus neoformans in murine model

Tahseen H. Nasti, Masood A. Khan and M. Owais.

in Journal of Antimicrobial Chemotherapy

February 2006; p ublished online December 2005 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2884 words.

Objectives: To evaluate the efficacy of pH-sensitive liposomes of nystatin against Cryptococcus neoformans infection in a murine model.

Methods: In the...

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Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects

Ana M. Ponce, Benjamin L. Viglianti, Daohai Yu, Pavel S. Yarmolenko, Charles R. Michelich, Janet Woo, Marcel B. Bally and Mark W. Dewhirst.

in JNCI: Journal of the National Cancer Institute

January 2007; p ublished online January 2007 .

Journal Article. Subjects: Medical Oncology. 8857 words.

Background

In preclinical studies, lysolipid-based temperature-sensitive liposomes (LTSLs) containing chemotherapy drugs administered in...

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Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model

Philippe Cottagnoud, Cynthia M. Gerber, F. Acosta, Marianne Cottagnoud, Klaus Neftel and Martin G. Täuber.

in Journal of Antimicrobial Chemotherapy

December 2000; p ublished online December 2000 .

Journal Article. Subjects: Medical Oncology; Critical Care. 2473 words.

Linezolid, a new oxazolidinone antibiotic, showed good penetration (38 ± 4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two iv injections (20...

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A sensitive phenotypic assay for the determination of human immunodeficiency virus type 1 tropism

Nuria González, Mayte Pérez-Olmeda, Elena Mateos, Almudena Cascajero, Amparo Alvarez, Sanne Spijkers, Javier García-Pérez, Sonsoles Sánchez-Palomino, Ezequiel Ruiz-Mateos, Manuel Leal and José Alcami.

in Journal of Antimicrobial Chemotherapy

December 2010; p ublished online October 2010 .

Journal Article. Subjects: Medical Oncology; Critical Care. 4781 words.

Objectives

To develop a sensitive phenotypic assay based on recombinant viruses (RVs) for characterizing HIV-1 tropism.

Methodsnull...

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METB-02. A SENSITIVE METABOLIC SIGNATURE TO PREDICT IMMUNE RESPONSE AFTER IMMUNOTHERAPY FOR BRAIN TUMORS

Farhad Dastmalchi, Aida Karachi, Ram Khattri, Matthew E Merritt, Duane Mitchell and Maryam Rahman.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

We recently demonstrated that migration of dendritic cells (DCs) to the draining lymph nodes...

Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

Daniela Meco, Tiziana Servidei, Giuseppe Lamorte, Elena Binda, Vincenzo Arena and Riccardo Riccardi.

in Neuro-Oncology

August 2014; p ublished online February 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 6122 words.

Background

Ependymoma management remains challenging because of the inherent chemoresistance of this tumor. To determine whether ependymoma stem cells (SCs)...

CADD-18. MP-Pt(IV): A MAOB SENSITIVE MITOCHONDRIAL SMART BOMB FOR TREATING GLIOMA

Martyn Sharpe and David Baskin.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

We have previously demonstrated that monoamine oxidase B (MAOB), highly elevated in glioma, may be used to catalytically convert uncharged...

An oncolytic measles virus–sensitive Group 3 medulloblastoma model in immune-competent mice

Sangeet Lal, Diego Carrera, Joanna J Phillips, William A Weiss and Corey Raffel.

in Neuro-Oncology

November 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 6187 words.

Abstract

Background

Oncolytic measles virus (MV) is effective in xenograft models of many tumor types in...

EXTH-72. MP-Pt(IV): A MAOB SENSITIVE MITOCHONDRIAL SMART BOMB FOR TREATING GLIOMA

Martyn Sharpe, David Baskin and Sudhir Raghavan.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

We have previously demonstrated that monoamine oxidase B (MAOB), highly elevated in glioma, may be used to catalytically convert uncharged...

Reply to the letter to the editor ‘Many men with castrate-sensitive metastatic prostate cancer should not receive chemotherapy’ by Tannock et al.

C. Parker, S. Gillessen, A. Heidenreich and A. Horwich.

in Annals of Oncology

April 2016; p ublished online January 2016 .

Journal Article. Subjects: Medical Oncology. 652 words.

Reply to “Many men with castrate-sensitive metastatic prostate cancer should not receive chemotherapy” (ANNONC-2015-1902) by Tannock & Sternberg

Mutations of the Twik-Related Acid-Sensitive K+ Channel 2 Promoter in Human Primary Aldosteronism

Livia Lenzini, Selene Prisco, Michele Gallina, Maniselvan Kuppusamy and Gian Paolo Rossi.

in Endocrinology

P ublished online December 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 4488 words.

Abstract

Because blunted expression of the twik-related acid-sensitive K+ channel 2 (TASK-2) is a common feature of aldosterone-producing adenoma (APA) causing...

Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives

J. Sehouli, V. Alfaro and A. González-Martín.

in Annals of Oncology

March 2012; p ublished online July 2011 .

Journal Article. Subjects: Medical Oncology. 4173 words.

The effectiveness of platinum re-treatment in relapsed ovarian cancer depends on relapse-free/treatment-free intervals. Platinum agents can be effectively readministered to...

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Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer

J. V. Heymach, D. H. Johnson, F. R. Khuri, H. Safran, L. L. Schlabach, F. Yunus, R. F. DeVore, P. M. De Porre, H. M. Richards, X. Jia, S. Zhang and B. E. Johnson.

in Annals of Oncology

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Medical Oncology. 5329 words.

Background: R115777 (tipifarnib, Zarnestra™) is a farnesyl transferase inhibitor that blocks the farnesylation of proteins involved in signal transduction pathways critical for...

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Fluorescence-labeled Methylation-sensitive Amplified Fragment Length Polymorphism (FL-MS-AFLP) Analysis for Quantitative Determination of DNA Methylation and Demethylation Status

Shinji Kageyama, Kazuya Shinmura, Hiroko Yamamoto, Masanori Goto, Koichi Suzuki, Fumihiko Tanioka, Toshihiro Tsuneyoshi and Haruhiko Sugimura.

in Japanese Journal of Clinical Oncology

April 2008; p ublished online March 2008 .

Journal Article. Subjects: Medical Oncology. 2427 words.

The PCR-based DNA fingerprinting method called the methylation-sensitive amplified fragment length polymorphism (MS-AFLP) analysis is used for genome-wide scanning of methylation status. In...

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A phase II study of a paclitaxel and oxaliplatin combination in platinum-sensitive recurrent advanced ovarian cancer patients

P. Viens, T. Petit, A. Yovine, P. Bougnoux, G. Deplanque, P.-H. Cottu, R. Delva, J.-P. Lotz, S. V. Belle, J.-M. Extra and E. Cvitkovic.

in Annals of Oncology

March 2006; p ublished online March 2006 .

Journal Article. Subjects: Medical Oncology. 5802 words.

Purpose: A multicentric, phase II study to evaluate the efficacy and safety of the combination paclitaxel and oxaliplatin in patients with platinum-sensitive recurrent ovarian...

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Platinum versus platinum-combination chemotherapy in platinum-sensitive recurrent ovarian cancer: a meta-analysis using individual patient data

F. A. Raja, N. Counsell, N. Colombo, J. Pfisterer, A. du Bois, M. K. Parmar, I. B. Vergote, A. Gonzalez-Martin, D. S. Alberts, M. Plante, V. Torri and J. A. Ledermann.

in Annals of Oncology

December 2013; p ublished online December 2013 .

Journal Article. Subjects: Medical Oncology. 3224 words.

Background

The majority of women with ovarian cancer develop recurrent disease. For patients with a platinum-free interval of >6 months, platinum-based...

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Characterization of New Estrogen Receptor Destabilizing Compounds: Effects on Estrogen-Sensitive and Tamoxifen-Resistant Breast Cancer

Jens Hoffmann, Rolf Bohlmann, Nikolaus Heinrich, Helmut Hofmeister, Jörg Kroll, Hermann Künzer, Rosemarie B. Lichtner, Yuki Nishino, Karsten Parczyk, Gerhard Sauer, Hille Gieschen, Hannes-F. Ulbrich and Martin R. Schneider.

in JNCI: Journal of the National Cancer Institute

February 2004; p ublished online February 2004 .

Journal Article. Subjects: Medical Oncology. 6489 words.

Background: Antiestrogens of the selective estrogen receptor modulator (SERM) type, such as tamoxifen, have two major limitations: their mixed agonist and antagonist profile and...

Patterns of care in Dutch postmenopausal patients with hormone-sensitive early breast cancer participating in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial

J. G. H. van Nes, C. Seynaeve, E. Maartense, R. M. H. Roumen, R. S. de Jong, L. V. A. M. Beex, W. M. Meershoek-Klein Kranenbarg, H. Putter, J. W. R. Nortier and C. J. H. van de Velde.

in Annals of Oncology

May 2010; p ublished online October 2009 .

Journal Article. Subjects: Medical Oncology. 5002 words.

Background: The Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial investigates the efficacy and safety of adjuvant exemestane alone and in sequence after tamoxifen...

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Docetaxel and oxaliplatin in the second-line treatment of platinum-sensitive recurrent ovarian cancer: a phase II study

G Ferrandina, M Ludovisi, R De Vincenzo, V Salutari, D Lorusso, M Colangelo, T Prantera, MR Valerio and G Scambia.

in Annals of Oncology

August 2007; p ublished online April 2007 .

Journal Article. Subjects: Medical Oncology. 3565 words.

Background: A prospective phase II study was conducted to evaluate the efficacy and toxicity of the combination docetaxel (Taxotere) (DTX) and oxaliplatin (OXA) in ovarian...

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