Oxford Index Search Results

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sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

See overview in Oxford Index

Voltage-Sensitive Dye Imaging

William Frost and Jian-young Wu.

in Basic Electrophysiological Methods

February 2015; p ublished online April 2015 .

Chapter. Subjects: Neurology. 10970 words.

Voltage sensitive dye imaging (VSD) can be used to record neural activity in hundreds of locations in preparations ranging from mammalian cortex to invertebrate ganglia. Because fast VSDs...

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Cortisol fluctuations relate to interictal epileptiform discharges in stress sensitive epilepsy

Jolien S. van Campen, E. Lorraine Hompe, Floor E. Jansen, Demetrios N. Velis, Willem M. Otte, Fia van de Berg, Kees P. J. Braun, Gerhard H. Visser, Josemir W. Sander, Marian Joels and Maeike Zijlmans.

in Brain

June 2016; p ublished online March 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System; Sleep Medicine. 4093 words.

People with epilepsy often report seizures precipitated by stress. This is believed to be due to effects of stress hormones, such as cortisol, on neuronal excitability. Cortisol, regardless...

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Variably protease-sensitive prionopathy in the UK: a retrospective review 1991–2008

Mark W. Head, Helen M. Yull, Diane L. Ritchie, Jan P. Langeveld, Nicholas A. Fletcher, Richard S. Knight and James W. Ironside.

in Brain

April 2013; p ublished online April 2013 .

Journal Article. Subjects: Neurology; Neuroscience. 8912 words.

Variably protease-sensitive prionopathy is a newly described human prion disease of unknown aetiology lying out with the hitherto recognized phenotypic spectrum of Creutzfeldt–Jakob...

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METB-02. A SENSITIVE METABOLIC SIGNATURE TO PREDICT IMMUNE RESPONSE AFTER IMMUNOTHERAPY FOR BRAIN TUMORS

Farhad Dastmalchi, Aida Karachi, Ram Khattri, Matthew E Merritt, Duane Mitchell and Maryam Rahman.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

INTRODUCTION

We recently demonstrated that migration of dendritic cells (DCs) to the draining lymph nodes...

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Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

Daniela Meco, Tiziana Servidei, Giuseppe Lamorte, Elena Binda, Vincenzo Arena and Riccardo Riccardi.

in Neuro-Oncology

August 2014; p ublished online February 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 6122 words.

Background

Ependymoma management remains challenging because of the inherent chemoresistance of this tumor. To determine whether ependymoma stem cells (SCs)...

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CADD-18. MP-Pt(IV): A MAOB SENSITIVE MITOCHONDRIAL SMART BOMB FOR TREATING GLIOMA

Martyn Sharpe and David Baskin.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

We have previously demonstrated that monoamine oxidase B (MAOB), highly elevated in glioma, may be used to catalytically convert uncharged...

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An oncolytic measles virus–sensitive Group 3 medulloblastoma model in immune-competent mice

Sangeet Lal, Diego Carrera, Joanna J Phillips, William A Weiss and Corey Raffel.

in Neuro-Oncology

November 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 6187 words.

Abstract

Background

Oncolytic measles virus (MV) is effective in xenograft models of many tumor types in...

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EXTH-72. MP-Pt(IV): A MAOB SENSITIVE MITOCHONDRIAL SMART BOMB FOR TREATING GLIOMA

Martyn Sharpe, David Baskin and Sudhir Raghavan.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

We have previously demonstrated that monoamine oxidase B (MAOB), highly elevated in glioma, may be used to catalytically convert uncharged...

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Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies

Denys Fontaine, Fabien Almairac, Serena Santucci, Charlotte Fernandez, Radhouane Dallel, Johan Pallud and Michel Lanteri-Minet.

in Brain

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System; Pain Medicine. 3753 words.

Abstract

Our knowledge on intracranial pain-sensitive structures in humans comes essentially from observations during neurosurgical procedures performed in...

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A network of occipito‐temporal face‐sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing

Bruno Rossion, Roberto Caldara, Mohamed Seghier, Anne‐Marie Schuller, Francois Lazeyras and Eugene Mayer.

in Brain

November 2003; p ublished online November 2003 .

Journal Article. Subjects: Neurology; Neuroscience. 8989 words.

Neuroimaging studies have identified at least two bilateral areas of the visual extrastriate cortex that respond more to pictures of faces than objects in normal human subjects in the middle...

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Genotype-specific patterns of atrophy progression are more sensitive than clinical decline in SCA1, SCA3 and SCA6

Kathrin Reetz, Ana S. Costa, Shahram Mirzazade, Anna Lehmann, Agnes Juzek, Maria Rakowicz, Romana Boguslawska, Ludger Schöls, Christoph Linnemann, Caterina Mariotti, Marina Grisoli, Alexandra Dürr, Bart P. van de Warrenburg, Dagmar Timmann, Massimo Pandolfo, Peter Bauer, Heike Jacobi, Till-Karsten Hauser, Thomas Klockgether and Jörg B. Schulz.

in Brain

March 2013; p ublished online February 2013 .

Journal Article. Subjects: Neurology; Neuroscience. 7603 words.

Spinocerebellar ataxias are dominantly inherited disorders that are associated with progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of the multicentre...

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Horizontal or vertical optokinetic stimulation activates visual motion-sensitive, ocular motor and vestibular cortex areas with right hemispheric dominance. An fMRI study.

M Dieterich, S F Bucher, K C Seelos and T Brandt.

in Brain

August 1998; p ublished online August 1998 .

Journal Article. Subjects: Neurology; Neuroscience. 0 words.

The differential effects of optokinetic stimulation with and without fixation suppression were analysed in an fMRI study in 10 right-handed healthy subjects. Horizontal and vertical...

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Dosage‐sensitive X‐linked locus influences the development of amygdala and orbitofrontal cortex, and fear recognition in humans

Catriona D. Good, Kate Lawrence, N. Simon Thomas, Cathy J. Price, John Ashburner, Karl J. Friston, Richard S. J. Frackowiak, Lars Oreland and David H. Skuse.

in Brain

November 2003; p ublished online November 2003 .

Journal Article. Subjects: Neurology; Neuroscience. 10341 words.

The amygdala, which plays a critical role in emotional learning and social cognition, is structurally and functionally sexually dimorphic in humans. We used magnetic neuroimaging and...

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NIMG-15. DIFFERENTIATION OF IDH1 MUTANT AND WILD TYPE GLIOMAS USING pH- AND OXYGEN-SENSITIVE MOLECULAR MRI

Jingwen Yao, Ararat Chakhoyan, Benjamin Ellingson, Whitney Pope, Noriko Salamon, William Yong, Albert Lai, Linda Liau, Phioanh Nghiemphu and Timothy Cloughesy.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

The presence of isocitrate dehydrogenase 1 (IDH1) gene mutation (IDH1mut) in glioma patients is associated with longer survival compared to IDH1...

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Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses

Gregory K. Friedman, Blake P. Moore, Li Nan, Virginia M. Kelly, Tina Etminan, Catherine P. Langford, Hui Xu, Xiaosi Han, James M. Markert, Elizabeth A. Beierle and G. Yancey Gillespie.

in Neuro-Oncology

February 2016; p ublished online July 2015 .

Journal Article. Subjects: Medical Oncology; Neurology. 4858 words.

Background

Childhood medulloblastoma is associated with significant morbidity and mortality that is compounded by neurotoxicity for the developing brain...

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Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

Ralf S. Schmid, Jeremy M. Simon, Mark Vitucci, Robert S. McNeill, Ryan E. Bash, Andrea M. Werneke, Lauren Huey, Kristen K. White, Matthew G. Ewend, Jing Wu and C. Ryan Miller.

in Neuro-Oncology

July 2016; p ublished online January 2016 .

Journal Article. Subjects: Medical Oncology; Neurology. 6582 words.

Background

Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy...

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PATH-01. DEVELOPMENT OF A SENSITIVE MULTIPLEX ASSAY FOR DETECTION OF MUTATIONS IN IDH1 AND IDH2

Anjen Chenn, Scott Parker, Sarah Perrey DeGeare, Lauren Kam-Morgan and Li Cai.

in Neuro-Oncology

November 2018; p ublished online November 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are the most frequently mutated metabolic genes in human cancer. They encode cytosolic and...

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HGG-44. STRESSED TO DEATH: EGFRvIII EXPRESSION RENDERS GLIOBLASTOMA CELLS MORE SENSITIVE TO ER STRESS INDUCING CHEMOTHERAPEUTICS

Regina Graham, Katrina Kostenko, Ingrid Torrens, Nicolas De Cordoba, Melanie Freire, Fedeline Camile and Steven Vanni.

in Neuro-Oncology

June 2018; p ublished online June 2018 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Epidermal growth factor receptor (EGFR) is often overexpressed and/or mutated cancer. The most common mutation is EGFRvIII and has been found to...

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EXTH-66. GLIOBLASTOMA CELLS FROM A PATIENT POST-TUMOR TREATING FIELDS (TTFIELDS) THERAPY ARE SENSITIVE TO TTFIELDS IN VITRO

Sharon K Michelhaugh, Sam Kiousis and Sandeep Mittal.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

BACKGROUND

Tumor treating fields (TTFields) are FDA-approved for treatment of newly-diagnosed and...

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Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine

Zheng Tian, Chao Dong, Kai Zhang, Lijia Chang and Kenji Hashimoto.

in International Journal of Neuropsychopharmacology

P ublished online August 2018 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 3298 words.

Abstract

Background

A recent study demonstrated that low-voltage-sensitive T-type calcium channel blocker...