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sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

See overview in Oxford Index

A Phase II clinical trial of pegylated liposomal doxorubicin and carboplatin in Japanese patients with platinum-sensitive recurrent ovarian, fallopian tube or primary peritoneal cancer

Toru Nakanishi, Daisuke Aoki, Yoh Watanabe, Yuichi Ando, Naoki Tomotsugu, Yuji Sato and Toshiaki Saito.

in Japanese Journal of Clinical Oncology

May 2015; p ublished online February 2015 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 3241 words.

Objective

This single-arm Phase II trial was designed to assess the safety and efficacy of pegylated liposomal doxorubicin and carboplatin combination...

Solitary plasmacytoma

Isabella Maund and Michael Williams.

in Oxford Case Histories in Oncology

February 2014; p ublished online April 2014 .

Chapter. Subjects: Radiation Oncology; Palliative Medicine. 1563 words.

Solitary plasmacytoma of bone is a rare but, potentially curable tumour. The histological finding of a plasma cell neoplasm should initiate investigations to determine whether there are...

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Traditional and Complementary Medicine in Pediatric Oncology and Low-Middle Income Countries: Recommendations from the International Society of Pediatric Oncology (SIOP), T&CM Collaborative

Elena J. Ladas, Stacey Marjerrison, Brijesh Arora, Peter B. Hesseling, Roberta Ortiz, Federico Antillon, Shalini Jatia and Glenn M. Afungchwi.

in Journal of the National Cancer Institute Monographs

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology. 2342 words.

Abstract

Significant strides have been made in the treatment of childhood cancer. Improvements in survival have led to increased attention toward supportive...

Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression

Eric Polley, Mark Kunkel, David Evans, Thomas Silvers, Rene Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly, Erik Harris, Nicole Fer, Dmitriy Sonkin, Gurmeet Kaur, Anne Monks, Shakun Malik, Joel Morris and Beverly A. Teicher.

in JNCI: Journal of the National Cancer Institute

P ublished online May 2016 .

Journal Article. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology. 6140 words.

Background: Small cell lung carcinoma (SCLC) is an aggressive, recalcitrant cancer, often metastatic at diagnosis and unresponsive to chemotherapy upon recurrence, thus it is...

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma

Valentina Audrito, Antonella Managò, Sofia La Vecchia, Federica Zamporlini, Nicoletta Vitale, Gianna Baroni, Simona Cignetto, Sara Serra, Cinzia Bologna, Aureliano Stingi, Francesca Arruga, Tiziana Vaisitti, Daniela Massi, Mario Mandalà, Nadia Raffaelli and Silvia Deaglio.

in JNCI: Journal of the National Cancer Institute

P ublished online September 2017 .

Journal Article. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology. 6872 words.

Abstract

Background

One of the effects of oncogenic signaling is metabolic reprogramming of tumor cells to support...

Weighing Risk of Cardiovascular Mortality Against Potential Benefit of Hormonal Therapy in Intermediate-Risk Prostate Cancer

Nataniel H. Lester-Coll, Skyler Johnson, William J. Magnuson, Samuel Z. Goldhaber, David J. Sher, Anthony V. D’Amico and James B. Yu.

in JNCI: Journal of the National Cancer Institute

June 2017; p ublished online December 2016 .

Journal Article. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology. 5599 words.

Abstract

Background: The purpose of this study is to determine the optimal strategy for men with newly diagnosed intermediate-risk prostate cancer...

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

Masatoshi Takagi, Misa Yoshida, Yoshino Nemoto, Hiroyuki Tamaichi, Rika Tsuchida, Masafumi Seki, Kumiko Uryu, Rina Nishii, Satoshi Miyamoto, Masahiro Saito, Ryoji Hanada, Hideo Kaneko, Satoru Miyano, Keisuke Kataoka, Kenichi Yoshida, Miki Ohira, Yasuhide Hayashi, Akira Nakagawara, Seishi Ogawa, Shuki Mizutani and Junko Takita.

in JNCI: Journal of the National Cancer Institute

P ublished online August 2017 .

Journal Article. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology. 5956 words.

Abstract

Background: Neuroblastoma (NB) is the most common solid tumor found in children, and deletions within the 11q region are observed in 11%...

Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

Masanori Kawakami, Lisa Maria Mustachio, Jaime Rodriguez-Canales, Barbara Mino, Jason Roszik, Pan Tong, Jing Wang, J. Jack Lee, Ja Hye Myung, John V. Heymach, Faye M. Johnson, Seungpyo Hong, Lin Zheng, Shanhu Hu, Pamela Andrea Villalobos, Carmen Behrens, Ignacio Wistuba, Sarah Freemantle, Xi Liu and Ethan Dmitrovsky.

in JNCI: Journal of the National Cancer Institute

June 2017; p ublished online February 2017 .

Journal Article. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology. 5855 words.

Abstract

Background: The first generation CDK2/7/9 inhibitor seliciclib (CYC202) causes multipolar anaphase and apoptosis in lung cancer cells...

Pharmacotherapy for recurrent ovarian cancer: current status and future perspectives

Koji Matsumoto, Takashi Onda and Nobuo Yaegashi.

in Japanese Journal of Clinical Oncology

May 2015; p ublished online March 2015 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 1974 words.

Several ‘lines of therapy’ that utilize cytotoxic agents and are driven by platinum-free intervals are the current standard of care for patients with recurrent ovarian cancer. For patients...

Brain Metastases in Breast Cancer

Naoki Niikura, Shigehira Saji, Yutaka Tokuda and Hiroji Iwata.

in Japanese Journal of Clinical Oncology

December 2014; p ublished online October 2014 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 5338 words.

Brain metastases are less common than bone or visceral metastases in patients with breast cancer. The overall prognosis of breast cancer patients with brain metastases remains poor, and...

The Increased Accumulation of [18F]Fluorodeoxyglucose in Untreated Prostate Cancer

Nobuyuki Oyama, Hironobu Akino, Yuji Suzuki, Hiroshi Kanamaru, Norihiro Sadato, Yoshiharu Yonekura and Kenichiro Okada.

in Japanese Journal of Clinical Oncology

December 1999; p ublished online December 1999 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 3758 words.

Background: To evaluate the clinical usefulness of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) compared with histopathological grading, clinical stage and...

Axitinib (AG-013736), an Oral Specific VEGFR TKI, Shows Potential Therapeutic Utility Against Cholangiocarcinoma

Hiroyuki Takahashi, Hidenori Ojima, Hiroko Shimizu, Junji Furuse, Hiroyuki Furukawa and Tatsuhiro Shibata.

in Japanese Journal of Clinical Oncology

June 2014; p ublished online April 2014 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 3314 words.

Objective

Cholangiocarcinoma is a refractory cancer whose incidence has been increasing worldwide in recent years. Neoangiogenesis plays an important role in...

Low-dose Irinotecan as a Second-line Chemotherapy for Recurrent Small Cell Lung Cancer

Masahiro Morise, Seiji Niho, Shigeki Umemura, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto, Hironobu Ohmatsu and Yuichiro Ohe.

in Japanese Journal of Clinical Oncology

September 2014; p ublished online July 2014 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 3006 words.

Objective

Irinotecan is a potent inhibitor of deoxyribonucleic acid topoisomerase 1 and the weekly schedule of 100–125 or 350 mg/m2 administration on Day 1...

A New Human Lung Adenocarcinoma Cell Line Harboring the EML4-ALK Fusion Gene

Hideko Isozaki, Masayuki Yasugi, Nagio Takigawa, Katsuyuki Hotta, Eiki Ichihara, Akihiko Taniguchi, Shinichi Toyooka, Shinsuke Hashida, Toshiaki Sendo, Mitsune Tanimoto and Katsuyuki Kiura.

in Japanese Journal of Clinical Oncology

October 2014; p ublished online August 2014 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 2156 words.

Objective

The echinoderm microtubule associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene was identified in patients with non-small...

Clinical efficacy and prognostic factors of tumor progression in Japanese patients with advanced renal cell carcinoma treated with sorafenib

Tsunenori Kondo, Hayakazu Nakazawa, Mototsugu Oya, Go Kimura, Yasuhisa Fujii, Takashi Hatano, Nozomu Kawata, Haruki Kume, Masashi Morita, Koichi Nakajima, Yoshio Ohno, Takatsugu Okegawa, Shunji Takahashi, Yoshiaki Wakumoto and Shigeo Horie.

in Japanese Journal of Clinical Oncology

March 2015; p ublished online November 2014 .

Journal Article. Subjects: Clinical Medicine; Medical Oncology; Radiation Oncology; Surgical Oncology. 4094 words.

Objective

Result of clinical trial for registration purpose is often difficult to generalize because of its limited population in number and inclusion...