Oxford Index Search Results


sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

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Validation of a Rapid and Sensitive UPLC–MS-MS Method Coupled with Protein Precipitation for the Simultaneous Determination of Seven Pyrethroids in 100 µL of Rat Plasma by Using Ammonium Adduct as Precursor Ion

Sheelendra Pratap Singh, Nistha Dwivedi, Kanumuri Siva Rama Raju, Isha Taneja and Mohammad Wahajuddin.

in Journal of Analytical Toxicology

April 2016; p ublished online January 2016 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5680 words.

United States Environmental Protection Agency has recommended estimating pyrethroids’ risk using cumulative exposure. For cumulative risk assessment, it would be useful to have a...

A Sensitive GC-EIMS Method for Simultaneous Detection and Quantification of JWH-018 and JWH-073 Carboxylic Acid and Hydroxy Metabolites in Urine

Buddha D. Paul and Thomas Bosy.

in Journal of Analytical Toxicology

April 2015; p ublished online February 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 4138 words.

Synthetic cannabinoids, including JWH-018 and JWH-073, belong to a class of aminoalkylindoles (AAIs) that are smoked to produce an effect similar to tetrahydrocannabinol. Compounds in this...

up-regulation

Overview page. Subjects: Sports and Exercise Medicine — Chemistry.

An increase in the sensitivity of cells to a particular hormone, probably by increasing the number of specific receptors on the cell surface membrane that bind with that hormone....

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A Rapid Screen for Four Corticosteroids in Equine Synovial Fluid

Karan Agrawal, Joseph G. Ebel and Karyn Bischoff.

in Journal of Analytical Toxicology

June 2014; p ublished online April 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 4546 words.

Most antidoping method development in the equine industry has been for plasma and urine, though there has been recent interest in the analysis of synovial fluid for evidence of doping by...

‘Dilute-and-Shoot’ RSLC–MS-MS Method for Fast Detection of Nerve and Vesicant Chemical Warfare Agent Metabolites in Urine

Igor Rodin, Arcady Braun, Andrey Stavrianidi, Timur Baygildiev, Oleg Shpigun, Dmitry Oreshkin and Igor Rybalchenko.

in Journal of Analytical Toxicology

January 2015; p ublished online October 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 3046 words.

A sensitive screening method based on fast liquid chromatography tandem mass-spectrometry (RSLC–MS-MS) has shown the feasibility of separation and detection of low concentration β-lyase...

Evidence of Sulfur Mustard Exposure in Human Plasma by LC–ESI–MS-MS Detection of the Albumin-Derived Alkylated HETE–CP Dipeptide and Chromatographic Investigation of Its Cis/Trans Isomerism

Felix Gandor, Michael Gawlik, Horst Thiermann and Harald John.

in Journal of Analytical Toxicology

May 2015; p ublished online February 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 7567 words.

Sulfur mustard (SM) is a chemical warfare agent that causes painful blisters and chemically modifies endogenous biomacromolecules by alkylation to hydroxyethylthioethyl (HETE) adducts...

A Novel ‘Dilute-and-Shoot’ Liquid Chromatography–Tandem Mass Spectrometry Method for the Screening of Antihypertensive Drugs in Urine

Alexander J. Lawson, Kate E. Shipman, Stephen George and Indranil Dasgupta.

in Journal of Analytical Toxicology

January 2016; p ublished online September 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 7091 words.

Arterial hypertension is one of the most preventable causes of premature morbidity and mortality with resistant hypertension reported to be present in 5–30% of the total hypertensive...

Determination of Drugs in Plasma Samples by High-Performance Liquid Chromatography–Tandem Mass Spectrometry for Therapeutic Drug Monitoring of Schizophrenic Patients

Diego Soares Domingues, Mônia Aparecida Lemos Pinto, Israel Donizeti de Souza, Jaime Eduardo Cecilio Hallak, José Alexandre de Souza Crippa and Maria Eugênia Costa Queiroz.

in Journal of Analytical Toxicology

January 2016; p ublished online September 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5501 words.

This work describes the development of a simple, sensitive and selective method based on high-performance liquid chromatography coupled to tandem mass spectrometry (LC–MS-MS) to determine...

Validated Method for the Quantification of Baclofen in Human Plasma Using Solid-Phase Extraction and Liquid Chromatography–Tandem Mass Spectrometry

Limon Khatun Nahar, Rosa Elena Cordero, David Nutt, Anne Lingford-Hughes, Samuel Turton, Claire Durant, Sue Wilson and Sue Paterson.

in Journal of Analytical Toxicology

March 2016; p ublished online November 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 4891 words.

A highly sensitive and fully validated method was developed for the quantification of baclofen in human plasma. After adjusting the pH of the plasma samples using a phosphate buffer...

Ultrafast Screening of Synthetic Cannabinoids and Synthetic Cathinones in Urine by RapidFire-Tandem Mass Spectrometry

Jillian R. Neifeld, Laura E. Regester, Justin M. Holler, Shawn P. Vorce, Joseph Magluilo, Gerardo Ramos and Thomas Z. Bosy.

in Journal of Analytical Toxicology

June 2016; p ublished online May 2016 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5306 words.

Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable....

Development and Validation of a Novel LC-MS/MS Opioid Confirmation Assay: Evaluation of β-glucuronidase Enzymes and Sample Cleanup Methods

He S. Yang, Alan H. B. Wu and Kara L. Lynch.

in Journal of Analytical Toxicology

June 2016; p ublished online April 2016 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5314 words.

With the rise in the use and misuse of prescription opioids, there is an increasing need for the confirmed identification of opioid analgesics in toxicology laboratories. The goals of this...

Buprenorphine Detection in Urine Using Liquid Chromatography–High-Resolution Mass Spectrometry: Comparison with Cloned Enzyme Donor Immunoassay (ThermoFisher) and Homogeneous Enzyme Immunoassay (Immunalysis)

Sarah L. Belsey, Lewis Couchman and Robert J. Flanagan.

in Journal of Analytical Toxicology

September 2014; p ublished online June 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 3769 words.

A sensitive liquid chromatographic–high-resolution mass spectrometric (LC–HR-MS) assay for buprenorphine and its urinary metabolites has been developed that requires minimal sample...

Analysis of Zolpidem in Postmortem Fluids and Tissues Using Ultra-Performance Liquid Chromatography–Mass Spectrometry

Kristi S. Thompson, Russell J. Lewis and Roxane M. Ritter.

in Journal of Analytical Toxicology

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 3785 words.

Zolpidem is a nonbenzodiazepine sedative hypnotic drug used for the short-term treatment of insomnia. While quite effective in producing sedation, zolpidem has potentially hazardous side...

A Rapid Quantitative Method for the Analysis of Synthetic Cannabinoids by Liquid Chromatography–Tandem Mass Spectrometry

Tom D. Freijo, Steve E. Harris and Subbarao V. Kala.

in Journal of Analytical Toxicology

October 2014; p ublished online October 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5227 words.

Synthetic cannabinoids represent an emerging drug problem in the USA, as these compounds are constantly being modified and rapidly sold as soon as they become available. Laboratories around...

Impact of the Grinding Process on the Quantification of Ethyl Glucuronide in Hair Using a Validated UPLC–ESI–MS-MS Method

Natalie Kummer, Sarah M. R. Wille, Vincent Di Fazio, Maria Del Mar Ramírez Fernández, Michel Yegles, Willy E. E. Lambert and Nele Samyn.

in Journal of Analytical Toxicology

January 2015; p ublished online October 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5154 words.

The Society of Hair Testing (SoHT) has provided cutoffs for the quantification of ethyl glucuronide (EtG) in hair to indicate occasional or chronic/excessive alcohol consumption. Although...

Simultaneous Determination of 11 β-Agonists in Human Urine Using High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Isotope Dilution

Xiaoli Wang, Tao Guo, Shanshan Wang, Jinpeng Yuan and Rusong Zhao.

in Journal of Analytical Toxicology

April 2015; p ublished online December 2014 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 3314 words.

The misuse of β-agonists constitutes a potential risk to public health and has been forbidden in many countries. In this study, we describe a method for specific, sensitive and rapid...

A Validated LC–MS-MS Method for Simultaneous Identification and Quantitation of Rodenticides in Blood

Sergei Bidny, Kim Gago, Mark David, Thanh Duong, Desdemona Albertyn and Naren Gunja.

in Journal of Analytical Toxicology

April 2015; p ublished online January 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 3964 words.

A rapid, highly sensitive and specific analytical method for the extraction, identification and quantification of nine rodenticides from whole blood has been developed and validated....

Simultaneous Quantitation of 78 Drugs and Metabolites in Urine with a Dilute-And-Shoot LC–MS-MS Assay

Zheng Cao, Erin Kaleta and Ping Wang.

in Journal of Analytical Toxicology

June 2015; p ublished online April 2015 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 8626 words.

A novel LC–MS-MS assay that simultaneously detects and quantitates 78 drugs and metabolites was developed and validated for chronic pain management. Urine specimen was diluted and mixed...

An Efficient, Robust Method for the Determination of Cannabinoids in Whole Blood by LC–MS-MS

Nicholas B. Tiscione, Russell Miller, Xiaoqin Shan, Jessica Sprague and Dustin Tate Yeatman.

in Journal of Analytical Toxicology

October 2016; p ublished online September 2016 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 7243 words.

Due to the high prevalence of cannabinoids in forensic toxicology casework, it is desirable to have an efficient method that uses a small volume of blood and requires a minimal sample...

Detection of Carfentanil by LC–MS-MS and Reports of Associated Fatalities in the USA

Kevin G. Shanks and George S. Behonick.

in Journal of Analytical Toxicology

July 2017; p ublished online July 2017 .

Journal Article. Subjects: Medical Toxicology; Chemistry; Toxicology (Non-medical). 5326 words.

Abstract

Carfentanil is a mu (μ) opioid receptor agonist and is estimated to be ~10,000 times more potent than morphine in animal (non-human) models. It is not...