Oxford Index Search Results

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sensitive x Clinical Medicine x Biological Sciences x clear all


Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

See overview in Oxford Index

Differential Involvement of Conotoxin-Sensitive Mechanisms in Neurogenic Vasodilatation Responses

Zeinab Khalil, Merhi Merhi and Bruce G. Livett.

in The Journals of Gerontology: Series A

August 2001; p ublished online August 2001 .

Journal Article. Subjects: Geriatric Medicine; Biological Sciences. 5849 words.

During aging there is a decline in sensory nerve function that is associated with reduced neurogenic inflammation and poor wound repair. The cellular mechanism(s) responsible for this...

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Ochratoxin A Content of Human Sera Determined by a Sensitive ELISA

László Solti, Ferenc Salamon, Ildikó Barna-Vetró, Ágnes Gyöngyösi, Erzsébet Szabó and Anna Wölfling.

in Journal of Analytical Toxicology

January 1997; p ublished online January 1997 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

A sensitive, monoclonal antibody-based ELISA test was developed and used for quantitative determination of ochratoxin A (OA) in human sera. The measuring range of this test (without sample...

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Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi

Anne E. P. Frosch, Miriam K. Laufer, Don P. Mathanga, Shannon Takala-Harrison, Jacek Skarbinski, Cassidy W. Claassen, Fraction K. Dzinjalamala and Christopher V. Plowe.

in The Journal of Infectious Diseases

October 2014; p ublished online April 2014 .

Journal Article. Subjects: Infectious Diseases; Immunology; Public Health and Epidemiology; Microbiology. 2305 words.

Background.  The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in...

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Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population

Ronald N. Hines, Dana Sargent, Herman Autrup, Linda S. Birnbaum, Robert L. Brent, Nancy G. Doerrer, Elaine A. Cohen Hubal, Daland R. Juberg, Christian Laurent, Robert Luebke, Klaus Olejniczak, Christopher J. Portier and William Slikker.

in Toxicological Sciences

January 2010; p ublished online September 2009 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 16652 words.

Assessing the risk profiles of potentially sensitive populations requires a “tool chest” of methodological approaches to adequately characterize and evaluate these populations. At present,...

Comparative Efficacy of Antihypertensive Agents in Salt-Sensitive Hypertensive Patients: A Network Meta-Analysis

Han Qi, Zheng Liu, Han Cao, Wei-Ping Sun, Wen-Juan Peng, Bin Liu, Sheng-Jie Dong, Yu-Tao Xiang and Ling Zhang.

in American Journal of Hypertension

June 2018; p ublished online February 2018 .

Journal Article. Subjects: Cardiovascular Medicine; Biological Sciences. 6577 words.



Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential...

Rapid and Sensitive Quantitative Analysis of Alkyl Phosphates in Urine after Organophosphate Poisoning

N. Kupfermann, A. Schmoldt and H. Steinhart.

in Journal of Analytical Toxicology

May 2004; p ublished online May 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Organophosphate compounds are widely used as pesticides. After ingestion by humans, organophosphates decompose into alkyl phosphates. Decomposition continues postmortem. We developed a...

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A One-Step and Sensitive GC-MS Assay for Meprobamate Determination in Emergency Situations

Sandrine Daval, Damien Richard, Bertrand Souweine, Alain Eschalier and François Coudore.

in Journal of Analytical Toxicology

June 2006; p ublished online June 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

A rapid, sensitive, and ready-to-use gas chromatography-mass spectrometry method for meprobamate assay using carisoprodol as internal standard is described. The method involves extracting a...

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Fitness Parameters and DNA Effects Are Sensitive Indicators of Copper-Induced Toxicity in Daphnia magna

Franck A. Atienzar, Victoria V. Cheung, Awadhesh N. Jha and Michael H. Depledge.

in Toxicological Sciences

February 2001; p ublished online February 2001 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7098 words.

This study compared the effects occurring at molecular and population levels in Daphnia magna exposed to copper concentrations in the range of 15–120 μg/l. The qualitative and quantitative...

Cadmium-Induced Differential Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation

Joshua F. Robinson, Xiaozhong Yu, Sungwoo Hong, William C. Griffith, Richard Beyer, Euvin Kim and Elaine M. Faustman.

in Toxicological Sciences

January 2009; p ublished online October 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8047 words.

Common inbred mouse strains, such as the C57BL/6 (C57) and the SWV, display differences in sensitivity to environmental teratogens during gestation. For example, the C57 is more sensitive...

Effects of In Utero and Lactational TCDD Exposure on Bone Development in Differentially Sensitive Rat Lines

Hanna M. Miettinen, Pasi Pulkkinen, Timo Jämsä, Jaana Koistinen, Ulla Simanainen, Jouko Tuomisto, Juha Tuukkanen and Matti Viluksela.

in Toxicological Sciences

June 2005; p ublished online March 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7597 words.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a notorious model compound of highly toxic environmental pollutants, polychlorinated dibenzo-p-dioxins (PCDDs). Their toxic effects are...

Brain Fos Induction Is a Sensitive Biomarker for the Lowest Observed Neuroexcitatory Effects of Domoic Acid


in Toxicological Sciences

June 1996; p ublished online June 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Domoic acid induces Fos in several brain regions controlling memory processing and gastrointestinal functions. In the present study, we determined serum levels of domoic acid that caused...

A Rapid and Sensitive ESI-MS Screening Procedure for Ketamine and Norketamine in Urine Samples*

Ahai C. Lua and Huei R. Lin.

in Journal of Analytical Toxicology

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Traditionally, ketamine was analyzed with gas chromatography (GC) equipped with nitrogen-phosphorus detection, flame-ionization detection, and mass selective detection (MSD) or with liquid...

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A Rapid and Sensitive Technique for Assessing Exposure VX via GC-MS-MS Analysis

Jeffrey M. McGuire, Christopher E. Byers, Stanley W. Hulet, Edward M. Jakubowski and Sandra A. Thomson.

in Journal of Analytical Toxicology

January 2008; p ublished online January 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

A rapid and sensitive method for the determination of the chemical warfare agent VX in plasma taken from Göttingen minipigs® has been developed using isotope-dilution gas...

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Investigation of Drug-Induced Mitochondrial Toxicity Using Fluorescence-Based Oxygen-Sensitive Probes

James Hynes, Lisa D. Marroquin, Vladimir I. Ogurtsov, Katerina N. Christiansen, Gregory J. Stevens, Dmitri B. Papkovsky and Yvonne Will.

in Toxicological Sciences

July 2006; p ublished online April 2006 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8970 words.

Mitochondrial dysfunction is a common mechanism of drug-induced toxicity. Early identification of new chemical entities (NCEs) that perturb mitochondrial function is of significant...

Development of an Exonuclease Protection Mediated PCR Bioassay for Sensitive Detection of Ah Receptor Agonists

Xi Sun, Fang Li, You-jie Wang, Yi-rong Li, Yan-hua Su, Yuan-yuan Li, Hong Yan and Shun-qing Xu.

in Toxicological Sciences

July 2004; p ublished online April 2004 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4076 words.

The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin...

Resazurin Metabolism Assay Is a New Sensitive Alternative Test in Isolated Pig Cornea

Sébastien Perrot, Hélène Dutertre-Catella, Chantal Martin, Patrice Rat and Jean-Michel Warnet.

in Toxicological Sciences

March 2003; p ublished online March 2003 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 4782 words.

The main object of our study was to investigate whether the resazurin metabolism assay is a sensitive surfactant and alcohol toxicity test in isolated pig cornea and to compare this...

Metallothionein-I/II Null Mice Are Sensitive to Chronic Oral Cadmium-Induced Nephrotoxicity

Yaping Liu, Jie Liu, Sultan M. Habeebu, Michael P. Waalkes and Curtis D. Klaassen.

in Toxicological Sciences

September 2000; p ublished online September 2000 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5906 words.

Chronic exposure to cadmium (Cd) via food and drinking water is a major human health concern. We have previously shown that metallothionein (MT), a metal-binding protein, plays an important...

Blood Acylpeptide Hydrolase Activity Is a Sensitive Marker for Exposure to Some Organophosphate Toxicants

Gary B. Quistad, Rebecka Klintenberg and John E. Casida.

in Toxicological Sciences

August 2005; p ublished online May 2005 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5236 words.

Acylpeptide hydrolase (APH) unblocks N-acetyl peptides. It is a major serine hydrolase in rat blood, brain, and liver detected by derivatization with 3H-diisopropyl fluorophosphate (DFP) or...

Sensitive Markers Used to Identify Compounds That Trigger Apoptosis in Cultured Hepatocytes

María José Gómez-Lechón, Enrique O'Connor, José Vicente Castell and Ramiro Jover.

in Toxicological Sciences

February 2002; p ublished online February 2002 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7074 words.

Apoptosis may be a major event in chemical-induced injury, and therefore the detection of apoptotic effects when developing new drugs is highly relevant in screening for...

Contribution of Serum and Cellular Semicarbazide-Sensitive Amine Oxidase to Amine Metabolism and Cardiovascular Toxicity

D. J. Conklin, S. D. Langford and P. J. Boor.

in Toxicological Sciences

December 1998; p ublished online December 1998 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Semicarbazide-sensitive amine oxidase (SSAO) plays a role in the in vivo and in vitro toxicity of several environmental and endogenous amines. We investigated the role of SSAO as a...