Oxford Index Search Results

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sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

See overview in Oxford Index

No Associations Between Telomere Length and Age-Sensitive Indicators of Physical Function in Mid and Later Life

Karen Anne Mather, Anthony Francis Jorm, Peter John Milburn, Xiaoyun Tan, Simon Easteal and Helen Christensen.

in The Journals of Gerontology: Series A

August 2010; p ublished online April 2010 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 5075 words.

Telomere length, which declines with age, has been hypothesized to act as an indicator of biological aging. If it fulfills this purpose, shorter telomere length should correlate with...

Age-Related Changes in Subtelomeric Methylation in the Normal Japanese Population

Toyoki Maeda, Jing Zhi Guan, Jun-ichi Oyama, Yoshihiro Higuchi and Naoki Makino.

in The Journals of Gerontology: Series A

April 2009; p ublished online February 2009 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 4789 words.

Background

The telomeres of somatic cells become shorter with individual aging. However, no significant change in subtelomeric methylation of somatic cells...

Influence of Calorie Restriction on Measures of Age-Related Cognitive Decline: Role of Increased Physical Activity

Christy S. Carter, Christiaan Leeuwenburgh, Michael Daniels and Thomas C. Foster.

in The Journals of Gerontology: Series A

August 2009; p ublished online May 2009 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 6245 words.

Controversy exists as to whether lifelong 40% calorie restriction (CR) enhances, has no effect on, or disrupts cognitive function during aging. Here, we report the effects of CR versus...

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Sebastian I. Arriola Apelo and Dudley W. Lamming.

in The Journals of Gerontology: Series A

July 2016; p ublished online May 2016 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 8519 words.

Rapamycin (sirolimus) is a macrolide immunosuppressant that inhibits the mechanistic target of rapamycin (mTOR) protein kinase and extends lifespan in model organisms including mice....

Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors

Alex F. Bokov, Merry L. Lindsey, Christina Khodr, Marian R. Sabia and Arlan Richardson.

in The Journals of Gerontology: Series A

August 2009; p ublished online May 2009 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 6339 words.

To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In...

Age- and Sex-Associated Plasma Proteomic Changes in Growth Hormone Receptor Gene–Disrupted Mice

Juan Ding, Darlene E. Berryman, Adam Jara and John J. Kopchick.

in The Journals of Gerontology: Series A

August 2012; p ublished online December 2011 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 7798 words.

Growth hormone receptor gene–disrupted (GHR−/−) mice are dwarf, insulin sensitive, and long lived despite being obese. In order to identify characteristics associated with their increased...

Functional Status in the Young–Old: Establishing a Working Prototype of an Extended-Instrumental Activities of Daily Living Scale

Robert Fieo, Jennifer J. Manly, Nicole Schupf and Yaakov Stern.

in The Journals of Gerontology: Series A

June 2014; p ublished online October 2013 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 5068 words.

Background.

Instrumental activities of daily living (IADLs) exhibit strong predictive power for the presence of dementia and mild cognitive impairment....

Correlates of Disability Among Elderly Retirees With “Subclinical” Cognitive Impairment

Donald R. Royall, Laura K. Chiodo and Marsha J. Polk.

in The Journals of Gerontology: Series A

September 2000; p ublished online September 2000 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 4670 words.

Background. We assessed the effects of impaired Executive Control Function (ECF) on Instrumental Activities of Daily Living (IADL) and level of care among...

Interventions to Promote Physical Activity by Older Adults

Abby C. King.

in The Journals of Gerontology: Series A

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 9832 words.

Physical inactivity has been established to be an independent risk factor for a range of chronic diseases and conditions that threaten the health of the nation. However, only a minority of...

Decreased Food Intake With Aging

John E. Morley.

in The Journals of Gerontology: Series A

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 6795 words.

There is a physiological decline in food intake with aging. The reasons for the decline in food intake are multifactorial and involve both peripheral and central mechanisms....

Assessment of Mitochondrial Biogenesis and mTORC1 Signaling During Chronic Rapamycin Feeding in Male and Female Mice

Joshua C. Drake, Frederick F. Peelor, Laurie M. Biela, Molly K. Watkins, Richard A. Miller, Karyn L. Hamilton and Benjamin F. Miller.

in The Journals of Gerontology: Series A

December 2013; p ublished online May 2013 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 5823 words.

Chronic inhibition of the protein synthesis regulator mTORC1 through rapamycin extends life span in mice, with longer extension in females than in males. Whether rapamycin treatment...

A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age

Darlene E. Berryman, Ellen R. Lubbers, Vishakha Magon, Edward O. List and John J. Kopchick.

in The Journals of Gerontology: Series A

February 2014; p ublished online May 2013 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 7265 words.

Reduced growth hormone (GH) action is associated with extended longevity in many vertebrate species. GH receptor (GHR) null (GHR /−) mice, which have a disruption in the GHR...

Age-Related and Depot-Specific Changes in White Adipose Tissue of Growth Hormone Receptor-Null Mice

Lucila Sackmann-Sala, Darlene E. Berryman, Ellen R. Lubbers, Han Zhang, Clare B. Vesel, Katie M. Troike, Elahu S. Gosney, Edward O. List and John J. Kopchick.

in The Journals of Gerontology: Series A

January 2014; p ublished online July 2013 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 6045 words.

Growth hormone receptor-null (GHR−/−) mice are dwarf, insulin sensitive, and long-lived in spite of increased adiposity. However, their adiposity is not uniform, with select white adipose...

Aging-Associated Reductions in Lipolytic and Mitochondrial Proteins in Mouse Adipose Tissue Are Not Rescued by Metformin Treatment

Elise Mennes, Cory M. Dungan, Scott Frendo-Cumbo, David L. Williamson and David C. Wright.

in The Journals of Gerontology: Series A

September 2014; p ublished online October 2013 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 5286 words.

Mitochondrial enzyme expression is reduced in adipose tissue from old mice, yet little is known regarding mechanisms that could be mediating, or interventions that could be used, to reverse...

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

José A. López-Domínguez, Jon J. Ramsey, Dianna Tran, Denise M. Imai, Amanda Koehne, Steven T. Laing, Stephen M. Griffey, Kyoungmi Kim, Sandra L. Taylor, Kevork Hagopian, José M. Villalba, Guillermo López-Lluch, Plácido Navas and Roger B. McDonald.

in The Journals of Gerontology: Series A

October 2015; p ublished online October 2014 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 6917 words.

Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs), and...

Exercise Training Reverses Unparallel Downregulation of MaxiK Channel α- and β1-Subunit to Enhance Vascular Function in Aging Mesenteric Arteries

Lijun Shi, Bailin Liu, Yanyan Zhang, Zhimin Xue, Yujia Liu and Yu Chen.

in The Journals of Gerontology: Series A

December 2014; p ublished online December 2013 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 7009 words.

This study was designed to determine the effects of aerobic exercise training on aging-associated selective changes of the function and expression of the large-conductance Ca2+-activated K+null...

Expression of Apoptosis-Related Genes in Liver-Specific Growth Hormone Receptor Gene–Disrupted Mice Is Sex Dependent

Adam Gesing, Feiya Wang, Edward O. List, Darlene E. Berryman, Michal M. Masternak, Andrzej Lewinski, Malgorzata Karbownik-Lewinska, John J. Kopchick and Andrzej Bartke.

in The Journals of Gerontology: Series A

January 2015; p ublished online February 2014 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 5268 words.

Apoptosis is a process that affects life span and health. Mice with liver-specific disruption of the growth hormone receptor (GHR) gene (ie, Ghr gene) liver-specific growth hormone receptor...

Assessment of Metabolic Flexibility of Old and Adult Mice Using Three Noninvasive, Indirect Calorimetry-Based Treatments

Loes P. M. Duivenvoorde, Evert M. van Schothorst, Hans J. M. Swarts and Jaap Keijer.

in The Journals of Gerontology: Series A

March 2015; p ublished online March 2014 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 8761 words.

Indirect calorimetry (InCa) can potentially be used to noninvasively assess metabolic and age-related flexibility. To assess the use of InCa for this purpose, we tested the sensitivity and...

Functional and Morphological Evidence of Age-Related Denervation in Rat Laryngeal Muscles

Colleen A. McMullen and Francisco H. Andrade.

in The Journals of Gerontology: Series A

April 2009; p ublished online February 2009 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 4452 words.

Laryngeal muscle dysfunction compromises voice, swallowing, and airway protection in elderly adults. Laryngeal muscles and their motor neurons and their motor neurons communicate via the...

Adipose Tissue Infiltration in Skeletal Muscle of Healthy Elderly Men: Relationships With Body Composition, Insulin Resistance, and Inflammation at the Systemic and Tissue Level

Elena Zoico, Andrea Rossi, Vincenzo Di Francesco, Anna Sepe, Debora Olioso, Francesca Pizzini, Francesco Fantin, Ottavio Bosello, Luciano Cominacini, Tamara B. Harris and Mauro Zamboni.

in The Journals of Gerontology: Series A

March 2010; p ublished online October 2009 .

Journal Article. Subjects: Geriatric Medicine; Public Health; Biological Sciences; Molecular and Cell Biology; Neuroscience. 2680 words.

Background

Association between inflammatory markers and intermuscular adipose tissue (IMAT) has been reported. We hypothesized that subclinical inflammation...