Oxford Index Search Results


sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

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Primary ciliary dyskinesia

Claire Hogg.

in Ciliopathies

September 2013; p ublished online October 2013 .

Chapter. Subjects: Clinical Genetics. 9984 words.

Primary ciliary dyskinesia (PCD) is an inherited disorder affecting the structure and function of the motile cilia which line the entire respiratory tract. Damage to the structure of cilia...

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RAI1, Smith-Magenis Syndrome, and Potocki-Lupski Syndrome

Melanie Lacaria, Weimin Bi and James R. Lupski.

in Epstein's Inborn Errors of Development

June 2016; p ublished online July 2016 .

Chapter. Subjects: Clinical Genetics. 7000 words.

Smith-Magenis and Potocki-Lupski syndromes are two prototypical genomic disorders caused by reciprocal deletion or duplication, respectively, of chromosome 17p11.2. The recurrent...

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Neuropsychiatry and Neuropsychology

David Craufurd and Julie S. Snowden.

in Huntington's Disease

March 2014; p ublished online August 2014 .

Chapter. Subjects: Clinical Genetics. 20895 words.

Huntington's Disease (HD) causes a combination of motor, cognitive, and psychiatric changes; of these, the behavioral and cognitive aspects cause the greatest disability and have the...

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Deriving and Using a Risk Figure

R. J. McKinlay Gardner, Grant R. Sutherland and Lisa G. Shaffer.

in Chromosome Abnormalities and Genetic Counseling

November 2011; p ublished online October 2012 .

Chapter. Subjects: Clinical Genetics. 3696 words.

RISK IS A CENTRAL CONCEPT in genetic counseling. By risk, we mean the probability that a particular event will happen. Probability is conventionally measured with...

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The Management, Treatment, and Prevention of Genetic Disease

Peter S. Harper.

in A Short History of Medical Genetics

November 2008; p ublished online November 2013 .

Chapter. Subjects: Clinical Genetics; History of Medicine. 5951 words.

The origins and nature of the eugenics movement internationally are described and the abuses of genetics resulting from it examined. While originating in Britain in the late 19th century...

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Ocular Manifestations of Chromosomal Abnormalities

Sorath Noorani Siddiqui, Alex V. Levin, Matt Rusinek, Joanne E. Sutherland and Anthony G. Quinn.

in Genetic Diseases of the Eye, Second Edition

January 2012; p ublished online October 2012 .

Chapter. Subjects: Clinical Genetics; Ophthalmology. 39692 words.

The incidence of congenital ocular malformations is approximately 6 per 10,000, of which almost 8% are associated with abnormal karyotypes.1 This chapter is limited to the description of...

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In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation

Lara Barazzuol and Penny A. Jeggo.

in Journal of Radiation Research

August 2016; p ublished online August 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 5997 words.

The embryonic brain is radiation-sensitive, with cognitive deficits being observed after exposure to low radiation doses. Exposure of neonates to radiation can cause intracranial...

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General ion recombination effect in a liquid ionization chamber in high-dose-rate pulsed photon and electron beams

Hideyuki Takei, Tomonori Isobe, Nozomi Kitamura, Yutaro Mori, Tetsuya Tomita, Daisuke Kobayashi, Satoshi Kamizawa, Tomoharu Sato, Hideyuki Sakurai and Takeji Sakae.

in Journal of Radiation Research

May 2018; p ublished online January 2018 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 2237 words.

Abstract

Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive...

NBS1 and multiple regulations of DNA damage response

Kenshi Komatsu.

in Journal of Radiation Research

August 2016; p ublished online August 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4836 words.

DNA damage response is finely tuned, with several pathways including those for DNA repair, chromatin remodeling and cell cycle checkpoint, although most studies to date have focused on...

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Two Major Factors Involved in the Reverse Dose-rate Effect for Somatic Mutation Induction are the Cell Cycle Position and LET Value

Hiroshi Tauchi, Hiroyuki Waku, Eigo Matsumoto, Sayaka Yara, Shino Okumura, Yoshiyuki Iwata, Kenshi Komatsu, Yoshiya Furusawa, Kiyomi Eguchi-Kasai and Akira Tachibana.

in Journal of Radiation Research

September 2009; p ublished online June 2009 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 0 words.

To study mechanisms which could be involved in the reverse dose rate effect observed during mutation induction after exposure to high LET radiation, synchronized mouse L5178Y cells were...

Analysis of p53 Dependent Damage Response in Sperm-irradiated Mouse Embryos

Megumi Toyoshima.

in Journal of Radiation Research

January 2009; p ublished online January 2009 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 0 words.

Ionizing radiation activates a series of DNA damage response, cell cycle checkpoints to arrest cells at G1/S, S and G2/M, DNA repair, and apoptosis. The DNA damage response is thought to be...

Effects of water on fingernail electron paramagnetic resonance dosimetry

Tengda Zhang, Zhixin Zhao, Haiying Zhang, Hezheng Zhai, Shuzhou Ruan, Ling Jiao and Wenyi Zhang.

in Journal of Radiation Research

September 2016; p ublished online September 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 5565 words.

Electron paramagnetic resonance (EPR) is a promising biodosimetric method, and fingernails are sensitive biomaterials to ionizing radiation. Therefore, kinetic energy released per unit mass...

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Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts

Naohiro Tsuyama, Hajime Mizuno, Atsushi Katafuchi, Yu Abe, Yumiko Kurosu, Mitsuaki Yoshida, Kenji Kamiya and Akira Sakai.

in Journal of Radiation Research

January 2015; p ublished online September 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 5054 words.

Ionizing radiation (IR) induces cellular stress responses, such as signal transduction, gene expression, protein modification, and metabolite change that affect cellular behavior. We...

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Metabolomic screening using ESI-FT MS identifies potential radiation-responsive molecules in mouse urine

Daisuke Iizuka, Susumu Yoshioka, Hidehiko Kawai, Shunsuke Izumi, Fumio Suzuki and Kenji Kamiya.

in Journal of Radiation Research

May 2017; p ublished online December 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 3469 words.

Abstract

The demand for establishment of high-throughput biodosimetric methods is increasing. Our aim in this study was to identify low-molecular-weight...

Determining survival fractions of Saccharomyces cerevisiae in response to ionizing radiation in liquid culture

Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Wenjian Li and Dong Lu.

in Journal of Radiation Research

November 2018; p ublished online August 2018 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 1954 words.

Abstract

Saccharomyces cerevisiae survival fractions (SFs) in response to X-ray radiation were determined by two new methods: an OD600-based...

Upregulation of microRNA-98 increases radiosensitivity in esophageal squamous cell carcinoma

Ying-Ying Jin, Qing-Juan Chen, Yang Wei, Ya-Li Wang, Zhong-Wei Wang, Kun Xu, Yun He and Hong-Bing Ma.

in Journal of Radiation Research

September 2016; p ublished online September 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4615 words.

Although radiation resistance is a common challenge in the clinical treatment of esophageal squamous cell carcinoma (ESCC), an effective treatment strategy has yet to be developed. Aberrant...

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Profiling of low molecular weight proteins in plasma from locally irradiated individuals

Reetta Nylund, Elina Lemola, Sonja Hartwig, Stefan Lehr, Anna Acheva, Jutta Jahns, Guido Hildebrandt and Carita Lindholm.

in Journal of Radiation Research

July 2014; p ublished online February 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4974 words.

In studies reported in the 1960s and since, blood plasma from radiation-exposed individuals has been shown to induce chromosome damage when transferred into lymphocyte cultures of...

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Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination

Maki Ohara, Yumi Funyu, Shunsuke Ebara, Yuki Sakamoto, Ryota Seki, Kenta Iijima, Akiko Ohishi, Junya Kobayashi, Kenshi Komatsu, Akira Tachibana and Hiroshi Tauchi.

in Journal of Radiation Research

July 2014; p ublished online March 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4570 words.

Ionizing radiation induces DNA double-strand breaks (DSBs). Mammalian cells repair DSBs through multiple pathways, and the repair pathway that is utilized may affect cellular radiation...

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Telomere length in Chernobyl accident recovery workers in the late period after the disaster

Jelena Reste, Gunda Zvigule, Tija Zvagule, Natalja Kurjane, Maija Eglite, Natalija Gabruseva, Dace Berzina, Juris Plonis and Edvins Miklasevics.

in Journal of Radiation Research

November 2014; p ublished online July 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 7093 words.

The outcome of the Chernobyl nuclear power plant (CNPP) accident was that a huge number of people were exposed to ionizing radiation. Previous studies of CNPP clean-up workers from Latvia...

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Increased effectiveness of carbon ions in the production of reactive oxygen species in normal human fibroblasts

Till Dettmering, Sebastian Zahnreich, Miriam Colindres-Rojas, Marco Durante, Gisela Taucher-Scholz and Claudia Fournier.

in Journal of Radiation Research

January 2015; p ublished online October 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 5369 words.

The production of reactive oxygen species (ROS), especially superoxide anions (O2 ·–), is enhanced in many normal and tumor cell types in response to ionizing radiation. The...

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