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sensitive x Research Methods in Life Sciences x Science and Mathematics x Genetics and Genomics x clear all

sensitive

Overview page. Subjects: Medicine and Health.

adj. possessing the ability to respond to a stimulus. The cells of the retina, for example, are sensitive to the stimulus of light and respond by sending nerve impulses to the...

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Simple, multiplexed, PCR-based barcoding of DNA enables sensitive mutation detection in liquid biopsies using sequencing

Anders Ståhlberg, Paul M. Krzyzanowski, Jennifer B. Jackson, Matthew Egyud, Lincoln Stein and Tony E. Godfrey.

in Nucleic Acids Research

June 2016; p ublished online April 2016 .

Journal Article. Subjects: Genetics and Genomics; Research Methods in Life Sciences. 4562 words.

Detection of cell-free DNA in liquid biopsies offers great potential for use in non-invasive prenatal testing and as a cancer biomarker. Fetal and tumor DNA fractions however can be...

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A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes

Kosuke Ishikawa, Yuta Kobayashi, Yutaro Wakabayashi, Shinya Watanabe and Kentaro Semba.

in Biology Methods and Protocols

P ublished online April 2018 .

Journal Article. Subjects: Biological Sciences; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology; Research Methods in Life Sciences. 5864 words.

Abstract

We devised a versatile vector system for efficient isolation of reporter cells responding to a certain condition of interest. This system combines...

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Experimental single-strain mobilomics reveals events that shape pathogen emergence

Joseph S. Schoeniger, Corey M. Hudson, Zachary W. Bent, Anupama Sinha and Kelly P. Williams.

in Nucleic Acids Research

August 2016; p ublished online July 2016 .

Journal Article. Subjects: Genetics and Genomics; Research Methods in Life Sciences. 7055 words.

Virulence genes on mobile DNAs such as genomic islands (GIs) and plasmids promote bacterial pathogen emergence. Excision is an early step in GI mobilization, producing a circular GI and a...

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Tri-nucleotide threading for parallel amplification of minute amounts of genomic DNA

Erik Pettersson, Mats Lindskog, Joakim Lundeberg and Afshin Ahmadian.

in Nucleic Acids Research

January 2006; p ublished online January 2006 .

Journal Article. Subjects: Genetics and Genomics; Research Methods in Life Sciences. 4905 words.

Efforts to correlate genetic variations with phenotypic differences are intensifying due to the availability of high-density maps of single nucleotide polymorphisms (SNPs) and the...

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Enhanced detection of microsatellite instability using pre-PCR elimination of wild-type DNA homo-polymers in tissue and liquid biopsies

Ioannis Ladas, Fangyan Yu, Ka Wai Leong, Mariana Fitarelli-Kiehl, Chen Song, Ravina Ashtaputre, Matthew Kulke, Harvey Mamon and G Mike Makrigiorgos.

in Nucleic Acids Research

July 2018; p ublished online April 2018 .

Journal Article. Subjects: Genetics and Genomics; Research Methods in Life Sciences. 4753 words.

Abstract

Detection of microsatellite-instability in colonoscopy-obtained polyps, as well as in plasma-circulating DNA, is frequently confounded by sensitivity...

3′LIFE: a functional assay to detect miRNA targets in high-throughput

Justin M. Wolter, Kasuen Kotagama, Alexandra C. Pierre-Bez, Mari Firago and Marco Mangone.

in Nucleic Acids Research

September 2014; p ublished online July 2014 .

Journal Article. Subjects: Research Methods in Life Sciences; Genetics and Genomics. 12640 words.

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene output at the post-transcriptional level by targeting degenerate elements primarily in 3′untranslated regions (3′UTRs) of...

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SL-quant: a fast and flexible pipeline to quantify spliced leader trans-splicing events from RNA-seq data

Carlo Yague-Sanz and Damien Hermand.

in GigaScience

P ublished online July 2018 .

Journal Article. Subjects: Biological Sciences; Bioinformatics and Computational Biology; Evolutionary Biology; Genetics and Genomics; Research Methods in Life Sciences. 3843 words.

Abstract

Background

The spliceosomal transfer of a short spliced leader (SL) RNA to an independent pre-mRNA...

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